Best GLP-1 Providers in South Dakota (2026)

Compare 163 GLP-1 telehealth providers available in South Dakota. Average compounded semaglutide cost: $199/mo.

163 providers$199/mo averageTelehealth legal

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Featured Partners · South Dakota

Featured GLP-1 providers serving South Dakota

WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more

  1. Top pick

    Compounded from

    $99/mo

    Save $1,250/mo vs Wegovy
    Get started →
  2. Compounded from

    $99/mo

    Save $1,250/mo vs Wegovy
    Get started →
  3. Compounded from

    $199/mo

    Save $1,150/mo vs Wegovy
    Get started →
  4. Compounded from

    $179/mo

    Save $1,170/mo vs Wegovy
    Get started →
  5. Compounded from

    $99/mo

    Save $1,250/mo vs Wegovy
    Get started →
  6. Compounded from

    $146/mo

    Save $1,203/mo vs Wegovy
    Get started →

See by medication

Looking for a specific GLP-1? Browse South Dakota providers by drug.

About GLP-1s in South Dakota

South Dakota allows telehealth GLP-1 prescribing. South Dakota Medicaid covers GLP-1s only for type 2 diabetes diagnosis.

  • South Dakota's adult obesity rate is 33.2%
  • SD Medicaid limits GLP-1 coverage to diabetes
  • Telehealth is essential for rural South Dakota residents

All GLP-1 Providers Available in South Dakota

8.3/ 10
Verified partner

Found

Best for: mainstream telehealth GLP-1 access

★★★★4.2/5

Editorial score · methodology

$99/mosemaglutide
$99/motirzepatide
CompoundedSemaglutideTirzepatideOrforglipron
Get StartedRead full Found review →
8.3/ 10
Verified partner

CoreAge Rx

Best for: best overall value

★★★★4.2/5

Editorial score · methodology

$99/mosemaglutide
$149/motirzepatide
CompoundedSemaglutideTirzepatideNAD+SermorelinLegitScript Verified
Get StartedRead full CoreAge Rx review →
8.2/ 10
Verified partner

Enhance MD

Best for: lab-monitored compounded GLP-1 with mandatory video visit

★★★★4.1/5

Editorial score · methodology

$112/mosemaglutide
$169/motirzepatide
CompoundedSemaglutideTirzepatideNAD+
Get StartedRead full Enhance MD review →
8.2/ 10
Verified partner

Gala

Best for: compounded GLP-1/GIP combo on a yearly plan with free shipping

★★★★4.1/5

Editorial score · methodology

$149/motirzepatide
CompoundedSemaglutideTirzepatideLegitScript Verified
Get StartedRead full Gala review →
8.1/ 10
Verified partner

Pallas Health

Best for: the most complete public disclosure of pharmacies and prescribing physicians we have found

★★★★4.1/5

Editorial score · methodology

$139/mosemaglutide
$179/motirzepatide
CompoundedSemaglutideTirzepatideNAD+
Get StartedRead full Pallas Health review →
Browse all 163 providers in South Dakota A–Z

Also consider: 302 providers with undisclosed state coverage

These providers offer GLP-1 weight loss service (verified on their own websites) but do not publish a complete state-availability list publicly — their intake flow determines eligibility. We have not independently confirmed South Dakota coverage for the providers below. Start the signup intake to check whether they serve your state before proceeding.

7.4/ 10
Verified partner

MadeMed

Best for: compounded GLP-1 in both injection and oral forms

★★★3.7/5

Editorial score · methodology

$219/mosemaglutide
$299/motirzepatide
CompoundedSemaglutideTirzepatideNAD+SermorelinLegitScript Verified
Get StartedRead full MadeMed review →
7.4/ 10

Telos Rx

Best for: Needle-free, microdosed compounded GLP-1 with lab-monitored care

★★★3.7/5

Editorial score · methodology

$49/mosemaglutide
$99/motirzepatide
CompoundedSemaglutideTirzepatideBPC-157CJC-1295 / Ipamorelin
Get StartedRead full Telos Rx review →
8.1/ 10
Verified partner

GobyMeds

Best for: budget-conscious shoppers

★★★★4.1/5

Editorial score · methodology

$93/mosemaglutide
$133/motirzepatide
CompoundedSemaglutideTirzepatide
Get StartedRead full GobyMeds review →
7.6/ 10
Verified partner

RNK Health

Best for: compounded GLP-1 alongside NAD+, peptide and longevity add-ons

★★★3.8/5

Editorial score · methodology

$197/mosemaglutide
$297/motirzepatide
CompoundedSemaglutideTirzepatideNAD+Sermorelin
Get StartedRead full RNK Health review →
7.6/ 10
Verified partner

SkinnyRx

Best for: mainstream telehealth GLP-1 access

★★★3.8/5

Editorial score · methodology

$149/mosemaglutide
$224/motirzepatide
CompoundedSemaglutideTirzepatideFDA Warning
Get StartedRead full SkinnyRx review →
6.9/ 10
Verified partner

YourEra

Best for: $99 first-month entry pricing on compounded GLP-1s

★★★3.5/5

Editorial score · methodology

$149/mosemaglutide
$179/motirzepatide
CompoundedSemaglutideTirzepatideNAD+LegitScript Verified
Get StartedRead full YourEra review →
Browse all 302 providers with undisclosed South Dakota coverage A–Z

Top Cities for GLP-1 Treatment in South Dakota

Telehealth providers ship to all South Dakota addresses, but demand is highest in these metro areas:

Sioux Falls GLP-1 providers →Rapid CityAberdeenBrookings

Prefer an in-person clinic? Browse the South Dakota GLP-1 clinic directory →

Insurance & Medicaid in South Dakota

South Dakota Medicaid GLP-1 Coverage
Diabetes only

Most insurance plans in South Dakota cover GLP-1s for type 2 diabetes (Ozempic, Mounjaro), but coverage for obesity-only indications (Wegovy, Zepbound) is much more limited and often requires prior authorization. If your insurance won't cover brand-name GLP-1s, compounded semaglutide through telehealth is typically the most affordable option at around $199/mo.

For the exact criteria, drug list, and appeal process, read our South Dakota Medicaid GLP-1 coverage & prior-authorization guide. For coverage backdoors, Zepbound is FDA-approved for obstructive sleep apnea, and Wegovy for kidney and cardiovascular indications, which some plans cover even when they exclude weight-loss-only use.

Obesity in South Dakota

According to CDC data, 33.2% of South Dakota adults have obesity (BMI of 30 or higher). This places South Dakota at #21 out of 50 states. Access to GLP-1 medications like semaglutide and tirzepatide has expanded significantly through telehealth, helping South Dakota residents get clinically supervised weight loss treatment from home.

To choose a medication, compare the clinical-trial results behind each drug, see our best semaglutide and tirzepatide provider rankings, or track the next-generation GLP-1 pipeline.

Frequently Asked Questions

Key terms, explained

New to GLP-1s? Tap any term for a quick, plain-English definition.

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