One80Rx Review
Semaglutide & tirzepatide GLP-1 weight-loss telehealth · Independently scored 6.8/10
Best for: low listed GLP-1 prices with flat dosing, including microdose and oral options
Price is where One80Rx scores best in our breakdown.
Semaglutide
Tirzepatide
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
No insurance needed · Vetted by our editors
One80Rx is a Tampa-based telehealth platform selling compounded semaglutide and tirzepatide injections, plus a GLP-1 microdose program, an oral GLP-1 and a long list of peptides. Listed prices start at $129/mo for semaglutide and $229/mo for tirzepatide, and the site promises flat pricing with no dose-change surcharge. The catch is that every price is a "from" figure confirmed only after provider review, and the brand launched in mid-2026.
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One80Rx at a glance
- Type
- GLP-1 telehealth provider
- Medications
- Semaglutide, Tirzepatide
- Starting price
- $129/mo (Card reads "from $129/mo"; the site says plans are confirmed after provider review.)
- Pricing model
- Flat — dose increases don't raise the monthly price
- What's included
- Medication · Consult · Shipping
- FDA status
- No FDA warning letter on record
How we scored One80Rx
Each dimension is scored algorithmically from One80Rx’s real pricing, drugs offered, verification status, and disclosed inclusions — using the same six-dimension framework we apply to every provider.
Value25%
7.7/10At $129/mo, One80Rx runs about 24% below the $169 median for GLP-1 providers. Pricing is flat across doses, so there is no escalation markup as you titrate up.
Effectiveness25%
7.4/10One80Rx offers both semaglutide and tirzepatide — the two GLP-1 molecules with the strongest published weight-loss trial outcomes. An oral/needle-free option is offered for patients who avoid injections.
User Experience15%
6.6/10Online intake and platform experience — consult included in the price; 8 platform features disclosed.
Trust & Safety15%
6.5/10Core details confirmed by our editors; no FDA warning letters on file.
Accessibility10%
5.3/10One80Rx's exact state footprint isn't published — confirm coverage in your state before signing up.
Support10%
5.1/10One80Rx provides standard clinician follow-up; no extended coaching or community program is disclosed.
Providers that don’t post pricing up front score lower on Value and carry a cost-transparency note in their review. Read the full methodology →
How we verified this One80Rx review
Last checked September 2026- Confirmed current pricing across 2 dose/plan tiers
- Confirmed what the monthly price does and doesn't include
- Checked the FDA warning-letter database for enforcement actions
- Walked the public intake/checkout flow on the provider's site
Pricing, availability, and compliance facts come from the provider's own site and primary regulatory records — see the sources below. Editorial confidence in this data: medium.
What we checked
- Provider's own pricing page
- $129–$229/mo across 2 dose/plan tiers — checked September 2026
- FDA warning-letter register
- No letter on file for this provider
What to expect when you sign up with One80Rx
We walked One80Rx’s public signup flow in September 2026 to document the process — the steps, pricing transparency, and what’s required — before you commit. (We don’t create accounts, enter medical information, or check out; this is the observable funnel, not a prescribing outcome.)
- 1"Check eligibility" opens a quiz that starts with lifestyle questions: your main goal, activity level, sleep, stress and biological sex
- 2Enter height, current weight and goal weight; the quiz shows your BMI and a projected timeline to your goal
- 3Medical screening: body shape, ethnicity, symptoms, diagnoses (thyroid cancer, pancreatitis and others), surgeries, prior GLP-1 use, medications and allergies
- 4Heart rate and side-effect tolerance, then a "Your Medical Review" screen with a "Success Probability" percentage
- 5Contact details: first and last name, then email and phone, then date of birth
- 6Shipping address (walk stopped here; no price had been shown in the intake up to this point)
- "From" prices appear on the homepage and the peptides page before you start, but the site says the plan price is confirmed only after provider review
- The three GLP-1 treatment pages show "Available by consultation" in place of a price
- The quiz shows a "92%" "Success Probability" before any clinician has seen your answers
- Name, email, phone, birth date and address are all requested before any plan or price is shown inside the intake
- Refund on non-approval is stated plainly: "$0 if you're not approved"
- We did not complete checkout or take the medication, so we cannot speak to delivery or results
One80Rx customer support
- Phone
- (813) 303-0607
- info@one80rx.com
- Hours
- Monday–Friday, 9:00 AM–5:00 PM
GLP-1 medications One80Rx offers
Tap any medication to read our plain-English guide — how it works, dosing, side effects, and what the trials found.
Pricing
Prices re-verified
Card reads "from $129/mo"; the site says plans are confirmed after provider review.
Card reads "from $229/mo"; the site says plans are confirmed after provider review.
Ready to get started?
Plans and promotions change often — check One80Rx's current pricing and active discounts before you decide.
What we like
- Low listed entry prices: semaglutide from $129/mo and tirzepatide from $229/mo
- Flat-rate pricing is promised with no consultation fee and no surcharge when your dose goes up
- $0 if a provider does not approve you, and the Terms refund you if no prescription is issued
- Four GLP-1 formats, including a lower-dose microdose program and a daily oral option
- Free 2–3 day shipping in temperature-controlled, unmarked packaging
- Support phone line and email published, with weekday hours of 9 AM to 5 PM
- Cancel from your patient portal by turning off auto-refill at least 48 hours before the next charge
Watch-outs
- Every price is a "from" figure confirmed only after provider review; the treatment pages show no price at all
- No price appears in the intake before it asks for your name, email, phone, birth date and shipping address
- Neither the compounding pharmacy nor the prescribing medical group is named anywhere on the site
- Shows a Trustpilot "4.8 / 5" rating, but no Trustpilot profile for the brand could be found
- Brand launched in mid-2026, yet the homepage claims "10k+" members beside a "1,743+ patients supported" counter
- Terms make you waive the right to fill your prescription at a pharmacy of your choice
- No refunds once medication is dispensed, and order cancellation is limited to 24 hours after purchase
- Compounded semaglutide and tirzepatide are not FDA-approved, as the site itself states
Is One80Rx worth it?
The short version of what One80Rx offers is low listed GLP-1 prices with flat dosing, including microdose and oral options. It runs $129/month, the same price at every dose, — toward the affordable end of the category, so cost isn't the reason to look elsewhere. Its standout is a needle-free oral option, which very few providers offer.
Beyond the medication itself, One80Rx offers a microdosing option and charges the same price at every dose.
How much One80Rx actually costs
Compounded semaglutide runs $129/month and compounded tirzepatide runs $229/month.
That puts One80Rx below the roughly $169 median ongoing price across the GLP-1 providers we track — a real cost advantage.
Live Vital (about $130/month) is one of the closest alternatives to weigh One80Rx against.
Medications: what One80Rx prescribes
One80Rx prescribes semaglutide (the active drug in Wegovy and Ozempic) and tirzepatide (the active drug in Zepbound and Mounjaro) — the two most-studied weight-loss molecules on the market today. The medication is compounded at a licensed pharmacy rather than sold as a brand pen, which is what keeps the price down. The trade-off is the one every compounded provider shares: compounded drugs aren't FDA-approved as finished products.
One80Rx's needle-free oral option is a real draw if you've been avoiding a GLP-1 because of injections. Just set expectations on the science: oral and buccal delivery of these peptides is far less studied than the injectable versions the trials used. Treat it as a convenience option, not a proven equal to the shot.
Who One80Rx is best for — and who should skip it
A good fit if you…
- are focused on the lowest ongoing monthly cost — $129/month is below the roughly $169 median we track across the category.
- are needle-averse and want a non-injectable option, since the oral route skips the weekly injection most GLP-1 programs require.
Look elsewhere if you…
- specifically want an FDA-approved brand-name pen instead of a compounded formulation — that's not what this provider fills.
- need to bill insurance, since like most of this market it's cash-pay with no claims filed on your behalf.
Trust, safety, and medical oversight
We found no FDA warning letter on file for it, though a clean record isn't the same as an endorsement — read the rest of this review for the full picture. As with any compounded program, the most important step you can take is confirming which licensed pharmacy fills your prescription and what's in the formulation — we explain how in our scoring methodology.
Bottom line
One80Rx earns its place on the shortlist mainly on price: at $129/month it's one of the more affordable ways to stay on a GLP-1, without obvious corners cut on access or oversight.
The Bottom Line
Price is where One80Rx scores best in our breakdown.
Ready to start with One80Rx?
Starting at $129/month. See current pricing and start your free consultation.
One80Rx might not be your best fit if…
We rank editorially, so here’s where a different provider we track may serve you better.
- If you want brand-name Ozempic, Wegovy, Mounjaro or Zepbound, consider GobyMeds.
- If the lowest possible monthly price is your top priority, consider Collective (from $59/mo).
- If you want built-in coaching and behavior-change support, consider Found.
Frequently Asked Questions
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Sources
The primary regulatory filings and peer-reviewed studies cited throughout this One80Rx review:
Sources & methodology — as of September 2026
- 1.Weight Loss Rankings — GLP-1 Pricing Index 2026 (our independent dataset)— WeightLossRankings.org.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
- 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 9.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
- 10.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 11.FDA — Mounjaro (tirzepatide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 12.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.
See One80Rx's current pricing
Plans start at $129/month. Start your free consultation to check eligibility and today's price.