RxSpan MD Review
Best for: shoppers wanting physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
RxSpan MD is a physician-led telehealth practice founded by Dr. John Diaz, a board-certified plastic surgeon, offering compounded GLP-1 weight loss — semaglutide and tirzepatide from $249/mo, as injections or oral capsules — plus brand-name Wegovy, Zepbound and Ozempic. It's unusually transparent: it names its 503A pharmacy partners (Belmar, Strive, Epiq Scripts, Casa Pharma) and medical group, ships free, and includes unlimited 24/7 support. Available in all 50 states.
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
No insurance needed · Vetted by our editors
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The Bottom Line
RxSpan MD is a solid telehealth option with balanced features and pricing.
How we scored RxSpan MD
Each dimension is scored algorithmically from RxSpan MD’s real pricing, drugs offered, verification status, and disclosed inclusions — using the same six-dimension framework we apply to every provider.
Value25%
6.0/10At $249/mo, RxSpan MD runs about 47% above the $169 median for GLP-1 providers.
Effectiveness25%
8.2/10RxSpan MD offers both semaglutide and tirzepatide — the two GLP-1 molecules with the strongest published weight-loss trial outcomes. FDA-approved brand options are available alongside compounded versions.
User Experience15%
7.2/10Online intake and platform experience — consult included in the price; 7 platform features disclosed.
Trust & Safety15%
8.6/10Key details fully confirmed by our editors; no FDA warning letters on file; dispenses through an accredited compounding pharmacy (last checked 2026-06-17).
Accessibility10%
8.1/10RxSpan MD treats patients in all 50 states.
Support10%
7.0/10Coaching/dietitian access included.
How we verified this RxSpan MD review
Last checked 2026-06-17- Confirmed current pricing across 7 dose/plan tiers
- Confirmed availability in all 50 states
- Confirmed what the monthly price does and doesn't include
- Checked the FDA warning-letter database for enforcement actions
- Walked the public intake/checkout flow on the provider's site
Pricing, availability, and compliance facts come from the provider's own site and primary regulatory records — see the sources below. Editorial confidence in this data: high.
GLP-1 medications RxSpan MD offers
Tap any medication to read our plain-English guide — how it works, dosing, side effects, and what the trials found.
Pricing
| Dose | Form | Price/mo |
|---|---|---|
| Compounded Semaglutide | compounded | $249 |
| Semaglutide Capsules | compounded | $249 |
| Compounded Tirzepatide | compounded | $329 |
| Tirzepatide Capsules | compounded | $349 |
| Zepbound | brand | $1069 |
| Ozempic | brand | $1299 |
| Wegovy | brand | $1349 |
What we like
- Physician-led — founded by Dr. John Diaz, a board-certified plastic surgeon with 20+ years' experience
- Compounded semaglutide and tirzepatide from $249/mo (injection or oral capsules), plus brand-name Wegovy, Zepbound and Ozempic
- Names its 503A pharmacy partners (Belmar, Strive, Epiq Scripts, Casa Pharma) and medical group
- LegitScript-certified (#50405601); free expedited shipping and unlimited 24/7 support included
- Available in all 50 states via a 2-minute assessment
Watch-outs
- Compounded pricing ($249 semaglutide / $329 tirzepatide) sits mid-to-high versus the cheapest telehealth options
- Brand-name GLP-1 is priced steeply (Wegovy $1,349, Ozempic $1,299, Zepbound $1,069)
- Multi-vertical practice (also hair, sexual health, longevity), not weight-loss-only
- Legal entity name isn't published on the site
Is RxSpan MD worth it? Our verdict
RxSpan MD positions itself around one thing: shoppers wanting physician-led, pharmacy-transparent compounded GLP-1 with brand-name options. It runs $249/month — a premium to the category, so the extras need to justify it. Coaching and follow-up are part of the package, not an upsell.
How much RxSpan MD actually costs
- Compounded semaglutide — $249/month
- Compounded semaglutide — $249/month
- Compounded tirzepatide — $329/month
- Compounded tirzepatide — $349/month
- Brand-name tirzepatide — $1069/month
- Brand-name semaglutide — $1299/month
For context, the typical ongoing price across the GLP-1 providers we track is around $169/month, so RxSpan MD's standing rate sits at the premium end.
Medications: what RxSpan MD prescribes
RxSpan MD prescribes semaglutide (the active drug in Wegovy and Ozempic) and tirzepatide (the active drug in Zepbound and Mounjaro) — the two molecules with the strongest published weight-loss trial outcomes. You can choose FDA-approved brand-name pens or lower-cost compounded versions — the compounded route is how the monthly price stays down, with the trade-off that compounded drugs aren't FDA-approved as finished products.
Who RxSpan MD is best for — and who should skip it
A good fit if you…
- want coaching and follow-up included, not sold separately.
- live anywhere in the US and want guaranteed access.
Look elsewhere if you…
- want the lowest total cost over 6–12 months — a flat-rate provider will likely beat the ongoing price.
- need to bill insurance — like most of this market, it's cash-pay.
Trust, safety, and medical oversight
RxSpan MD treats patients in all 50 states, and dispenses through an accredited compounding pharmacy. We found no FDA warning letters on file for the provider. As with any compounded program, the most important step you can take is confirming which licensed pharmacy fills your prescription and what's in the formulation — we explain how in our scoring methodology.
Bottom line
RxSpan MD costs more than the budget end of the market, so it makes the most sense if its specific extras matter to you. If they don't, you can likely get the same medication for less elsewhere.
Ready to start with RxSpan MD?
Starting at $249/month. See current pricing and start your free consultation.
Sources
The primary regulatory filings and peer-reviewed studies cited throughout this RxSpan MD review:
Sources & methodology — as of June 2026
- 1.Weight Loss Rankings — GLP-1 Pricing Index 2026 (our independent dataset)— WeightLossRankings.org.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
- 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 9.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
- 10.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 11.FDA — Mounjaro (tirzepatide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 12.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.
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Frequently Asked Questions
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Ready to start with RxSpan MD?
Starting at $249/month. See current pricing and start your free consultation.