Yes Clinic Review
Semaglutide & tirzepatide GLP-1 weight-loss telehealth · Independently scored 7.8/10
Best for: flat per-dose pricing, and seeing every price without a quiz or an account
Price is where Yes Clinic scores best in our breakdown.
Semaglutide
Tirzepatide
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
No insurance needed · Vetted by our editors
Yes Clinic sells compounded semaglutide and tirzepatide at one flat price that does not rise as your dose is titrated up — $129/mo for semaglutide and $149/mo for tirzepatide, with the consultation, shipping and membership all at $0. Every price is published on the product page without a quiz or an account. The trade-off is that the smallest plan is a three-month prepay charged upfront.
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Vetted alternatives to Yes Clinic
Editorial score · methodology
Editorial score · methodology
Editorial score · methodology
Yes Clinic at a glance
- Type
- GLP-1 telehealth provider
- Medications
- Semaglutide, Tirzepatide
- Starting price
- $129/mo
- Pricing model
- Flat — dose increases don't raise the monthly price
- What's included
- Medication · Consult · Shipping
- FDA status
- No FDA warning letter on record
How we scored Yes Clinic
Each dimension is scored algorithmically from Yes Clinic’s real pricing, drugs offered, verification status, and disclosed inclusions — using the same six-dimension framework we apply to every provider.
Value25%
8.7/10At $129/mo, Yes Clinic runs about 24% below the $170 median for GLP-1 providers. Pricing is flat across doses, so there is no escalation markup as you titrate up.
Effectiveness25%
8.3/10Yes Clinic offers both semaglutide and tirzepatide — the two GLP-1 molecules with the strongest published weight-loss trial outcomes.
User Experience15%
7.6/10Online intake and platform experience — consult included in the price; 6 platform features disclosed.
Trust & Safety15%
7.5/10Core details confirmed by our editors; no FDA warning letters on file.
Accessibility10%
6.3/10Yes Clinic's exact state footprint isn't published — confirm coverage in your state before signing up.
Support10%
6.1/10Yes Clinic provides standard clinician follow-up; no extended coaching or community program is disclosed.
Providers that don’t post pricing up front score lower on Value and carry a cost-transparency note in their review. Read the full methodology →
How we verified this Yes Clinic review
Last checked September 2026- Confirmed current pricing across 2 dose/plan tiers
- Confirmed what the monthly price does and doesn't include
- Checked the FDA warning-letter database for enforcement actions
- Walked the public intake/checkout flow on the provider's site
Pricing, availability, and compliance facts come from the provider's own site and primary regulatory records — see the sources below. Editorial confidence in this data: medium.
What we checked
- Provider's own pricing page
- $129–$149/mo across 2 dose/plan tiers — checked September 2026
- FDA warning-letter register
- No letter on file for this provider
What to expect when you sign up with Yes Clinic
We walked Yes Clinic’s public signup flow in September 2026 to document the process — the steps, pricing transparency, and what’s required — before you commit. (We don’t create accounts, enter medical information, or check out; this is the observable funnel, not a prescribing outcome.)
- 1Open the weight-loss category or a product page — every plan and price is visible with no quiz and no account
- 2Pick semaglutide or tirzepatide and choose a 3-month or 6-month plan
- 3Add to cart (walk stopped before checkout and account creation)
- 4A separate 60-second quiz exists for people who want a recommendation first
- The site states outright that no quiz and no account are needed to see any price
- The dose slider demonstrates the flat-price claim: moving the dose leaves the price unchanged
- There is no one-month option, so the real entry cost is $387 or $447 upfront rather than the headline monthly figure
- Consultation, shipping and membership are each itemised at $0
- The live Terms of Use still shows an unfilled {GOVERNING_LAW_STATE} placeholder, so governing law is undetermined
Yes Clinic customer support
GLP-1 medications Yes Clinic offers
Tap any medication to read our plain-English guide — how it works, dosing, side effects, and what the trials found.
Pricing
Prices re-verified
$387 for 3 months = $129/mo. 6 months is $699 = $116.50/mo and is labelled "price locked". No single-month plan renders. Flat at every dose.
$447 for 3 months and $894 for 6 months both work out at $149/mo, "price locked". No single-month plan renders. Flat at every dose.
Ready to get started?
Plans and promotions change often — check Yes Clinic's current pricing and active discounts before you decide.
What we like
- Flat price at every dose — $129/mo semaglutide, $149/mo tirzepatide, and it does not climb as you titrate
- At $129/mo semaglutide sits only $20 below tirzepatide, so stepping up costs little
- "Every price is on this page. No quiz and no account needed to see it" — no email wall to see cost
- Consultation ($30), shipping and membership are all listed at $0: "the price on the tile is the whole price"
- Full refund if you cancel before the pharmacy dispenses; cancel yourself from your account
- Bilingual site with a working EN/ES toggle
Watch-outs
- Smallest plan is a 3-month prepay — $387 or $447 charged upfront, not a monthly bill
- Their live Terms of Use still contains an unfilled template placeholder: governed by the laws of the State of {GOVERNING_LAW_STATE}
- No pharmacy partner is named despite a "LegitScript Certified" banner in the footer
- No state list published: "Services are not available in all states"
- Product pages served different prices in source HTML than they render, so quote the figure you see on screen
- Support is email-only; no phone number published
Is Yes Clinic worth it?
What Yes Clinic is selling, in one line, is flat per-dose pricing, and seeing every price without a quiz or an account. It runs $129/month, the same price at every dose, — toward the affordable end of the category, so cost isn't the reason to look elsewhere. Its flat, all-dose pricing is a genuine plus for anyone worried about cost climbing as they titrate up.
It charges the same price at every dose.
How much Yes Clinic actually costs
Compounded semaglutide runs $129/month and compounded tirzepatide runs $149/month.
That puts Yes Clinic below the roughly $170 median ongoing price across the GLP-1 providers we track — a real cost advantage.
Live Vital (about $130/month) is one of the closest alternatives to weigh Yes Clinic against.
Medications: what Yes Clinic prescribes
Yes Clinic prescribes semaglutide (the active drug in Wegovy and Ozempic) and tirzepatide (the active drug in Zepbound and Mounjaro) — the two molecules with the strongest published weight-loss trial outcomes. Rather than brand-name pens, you get a compounded formulation from a licensed pharmacy — the reason the monthly cost is lower. Just know compounded drugs aren't FDA-approved as finished products, the standard caveat in this market.
Who Yes Clinic is best for — and who should skip it
A good fit if you…
- are focused on the lowest ongoing monthly cost — $129/month is below the roughly $170 median we track across the category.
Look elsewhere if you…
- specifically want an FDA-approved brand-name pen instead of a compounded formulation — that's not what this provider fills.
- need to bill insurance, since like most of this market it's cash-pay with no claims filed on your behalf.
Trust, safety, and medical oversight
We found no FDA warning letter on file for it, though a clean record isn't the same as an endorsement — read the rest of this review for the full picture. As with any compounded program, the most important step you can take is confirming which licensed pharmacy fills your prescription and what's in the formulation — we explain how in our scoring methodology.
Bottom line
Yes Clinic earns its place on the shortlist mainly on price: at $129/month it's one of the more affordable ways to stay on a GLP-1, without obvious corners cut on access or oversight.
The Bottom Line
Price is where Yes Clinic scores best in our breakdown.
Ready to start with Yes Clinic?
Starting at $129/month. See current pricing and start your free consultation.
Yes Clinic might not be your best fit if…
We rank editorially, so here’s where a different provider we track may serve you better.
- If you want brand-name Ozempic, Wegovy, Mounjaro or Zepbound, consider GobyMeds.
- If the lowest possible monthly price is your top priority, consider Collective (from $59/mo).
- If you want built-in coaching and behavior-change support, consider MEDVi.
Frequently Asked Questions
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Sources
The primary regulatory filings and peer-reviewed studies cited throughout this Yes Clinic review:
Sources & methodology — as of September 2026
- 1.Weight Loss Rankings — GLP-1 Pricing Index 2026 (our independent dataset)— WeightLossRankings.org.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
- 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 9.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
- 10.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 11.FDA — Mounjaro (tirzepatide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 12.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.
See Yes Clinic's current pricing
Plans start at $129/month. Start your free consultation to check eligibility and today's price.