Framework Review
Best for: Cost-sensitive patients who want the most aggressive entry-tier pricing ($25/week ~ $100/mo) with a named 503B FDA-registered pharmacy partner (The Pharmacy Hub) and no membership fees, who are comfortable with limited public disclosure on states served and corporate-entity attribution.
Framework (yourframework.com) is a personalized-plan GLP-1 telehealth platform offering compounded semaglutide and tirzepatide. Distinctive positioning: 'Not a One-Size-Fits All Program / Personalised Plans That Adapt.' DIFFERENTIATED PHARMACY DESIGNATION — Framework explicitly discloses pharmacy partner 'The Pharmacy Hub' with 503B FDA Registration designation (503B is the FDA-registered outsourcing-facility pathway, distinct from the 503A patient-specific compounding most DTC competitors use). Pricing: 'Framework GLP 1s For As Low as $25/Week' (roughly $100/month) with '$0 membership fees.' US-licensed clinicians provide doctor-guided treatment selection. Phone: (888) 412-0666. Email: support@yourframework.com. Verbatim FDA disclaimer: 'These formulations are not approved by the U.S. Food and Drug Administration (FDA) and have not undergone clinical trials to evaluate their safety, efficacy, or therapeutic equivalence to any FDA-approved medications.' NOT disclosed publicly: states-served list, LegitScript ID, named medical director, corporate legal entity (LLC/Inc/PC), governing law, refund/cancellation policy. Live-verified 2026-05-19.
Medium confidence · Last verified 2026-05-19 via manual · How we verify provider data
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The Bottom Line
Framework is a solid telehealth option with balanced features and pricing.
Score Breakdown
Drugs Offered
Framework prescribes the following GLP-1 medications. Tap a drug to read our clinical guide with FDA label info, dosing schedules, side effects, and trial data.
Pricing
| Dose | Form | Price/mo |
|---|---|---|
| As low as $25/week (~$100/mo) | compounded | $100 |
| As low as $25/week (~$100/mo) | compounded | $100 |
✓ Pros
- •**Named 503B pharmacy partner (The Pharmacy Hub) explicitly disclosed** — uncommon in the WLR directory. 503B is the FDA-registered outsourcing facility pathway (distinct from 503A patient-specific compounding) and represents a different regulatory + quality-control framework.
- •Verbatim FDA compounded-medication disclaimer published — meets WLR transparency standard
- •'$25/week' pricing (~$100/mo) is among the most aggressive in the directory
- •$0 membership fees — no annual or platform fee structure
- •Phone support published with toll-free number (888) 412-0666
- •Personalized-plan positioning differentiates from one-size-fits-all marketplace platforms
✗ Cons
- •LegitScript ID / certification NOT disclosed on the homepage
- •Specific states-served list NOT publicly disclosed
- •Named medical director / clinical leadership NOT disclosed
- •Corporate legal entity (LLC/Inc/PC) NOT disclosed (no footer copyright designation visible)
- •Governing law / arbitration venue NOT publicly stated
- •Refund / cancellation policy NOT publicly detailed
- •Per-dose pricing tier structure NOT explicitly disclosed (only 'as low as $25/week' starting tier)
- •$25/week framing requires unit conversion (~$100/mo at 4 weeks; ~$108/mo at 52-week annual average) — direct monthly-cost comparison less clear than competitors using $/mo framing
- •503B FDA-registered pathway has different supply-chain economics than 503A — patients should verify whether their specific medication is dispensed from The Pharmacy Hub or a different 503A subcontractor
Ready to start with Framework?
Starting at $100/month. See current pricing and start your free consultation.
Sources & methodology
Our Framework review applies the same 6-dimension scoring framework we use for every provider. Pricing, FDA approval status, compounding rules, and clinical-trial efficacy claims are sourced from the primary regulatory and peer-reviewed literature below.
Sources & methodology — as of May 2026
- 1.Weight Loss Rankings — GLP-1 Pricing Index 2026 (our independent dataset)— WeightLossRankings.org.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
- 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 9.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
- 10.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 11.FDA — Mounjaro (tirzepatide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 12.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.
Alternatives to Framework
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Editorial score · methodology
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Frequently Asked Questions
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Ready to start with Framework?
Starting at $100/month. See current pricing and start your free consultation.