MediRX Review

Best for: people wanting LegitScript-certified compounded GLP-1 with low first-month promo pricing

MediRX is a telehealth weight-loss platform offering compounded GLP-1 injections — semaglutide starting at $149/month and tirzepatide starting at $199/month — plus NAD+ and a name-brand GLP-1 option. Care runs on OpenLoop Health: a licensed provider reviews your online intake and prescribes if appropriate, with fulfillment through OpenLoop's partnered U.S. licensed pharmacies. The site is LegitScript Certified and the operating entity, MediRX, Inc. of Wyoming, is disclosed, though it doesn't publish the exact states it serves.

By Eli Marsden · Founding Editor
Editorially reviewed (not clinically reviewed) · How we verify contentLast reviewed
7.3
★★★★☆3.7
Compounded GLP-1 injectionsLegitScript CertifiedPowered by OpenLoopSemaglutide from $149Tirzepatide from $199First-month promo pricingNAD+ also offeredFree shipping
$149/mo

What the monthly price covers

Medication

Included

Provider visits

Included

Shipping

Included

Lab work

Not disclosed

Coaching

Not disclosed

See plans →

No insurance neededVetted by our editors

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The Bottom Line

MediRX is a solid telehealth option with balanced features and pricing.

Score: 7.3/10Best for: people wanting LegitScript-certified compounded GLP-1 with low first-month promo pricingFrom: $149/mo

How we scored MediRX

Each dimension is scored algorithmically from MediRX’s real pricing, drugs offered, verification status, and disclosed inclusions — using the same six-dimension framework we apply to every provider.

Value25%

7.9/10

At $149/mo, MediRX runs about 12% below the $169 median for GLP-1 providers.

Effectiveness25%

7.9/10

MediRX offers both semaglutide and tirzepatide — the two GLP-1 molecules with the strongest published weight-loss trial outcomes.

User Experience15%

7.2/10

Online intake and platform experience — consult included in the price; 8 platform features disclosed.

Trust & Safety15%

7.1/10

Core details confirmed by our editors; no FDA warning letters on file (last checked 2026-06-09).

Accessibility10%

5.9/10

MediRX's exact state footprint isn't published — confirm coverage in your state before signing up.

Support10%

5.7/10

MediRX provides standard clinician follow-up; no extended coaching or community program is disclosed.

How we verified this MediRX review

Last checked 2026-06-09
  • Confirmed current pricing across 2 dose/plan tiers
  • Confirmed what the monthly price does and doesn't include
  • Checked the FDA warning-letter database for enforcement actions
  • Walked the public intake/checkout flow on the provider's site

Pricing, availability, and compliance facts come from the provider's own site and primary regulatory records — see the sources below. Editorial confidence in this data: medium.

GLP-1 medications MediRX offers

Tap any medication to read our plain-English guide — how it works, dosing, side effects, and what the trials found.

SemaglutideTirzepatideWegovyOzempicMounjaroZepboundRybelsus

Pricing

DoseFormPrice/mo
Injectablecompounded injection$149
Injectablecompounded injection$199

What we like

  • LegitScript Certified — a meaningful trust signal for an online pharmacy
  • Named operating entity disclosed (MediRX, Inc., Wyoming)
  • Care and pharmacy fulfillment run on OpenLoop Health's licensed network
  • Low promotional first-month pricing — semaglutide first month as low as $70

Watch-outs

  • Doesn't publish the exact states it serves; telehealth rules vary by state
  • Ongoing monthly price rises after the promotional first month
  • Compounded semaglutide and tirzepatide injections — limited oral options
  • Specific compounding pharmacies aren't named beyond the OpenLoop network

Is MediRX worth it? Our verdict

MediRX positions itself around one thing: people wanting LegitScript-certified compounded GLP-1 with low first-month promo pricing. It runs $149/month — toward the affordable end of the market.

How much MediRX actually costs

  • semaglutide — $149/month
  • tirzepatide — $199/month

That puts MediRX below the roughly $169 median ongoing price across the GLP-1 providers we track — a real cost advantage.

Medications: what MediRX prescribes

MediRX prescribes semaglutide (the active drug in Wegovy and Ozempic) and tirzepatide (the active drug in Zepbound and Mounjaro) — the two molecules with the strongest published weight-loss trial outcomes.

Who MediRX is best for — and who should skip it

A good fit if you…

  • are focused on the lowest ongoing monthly cost.

Look elsewhere if you…

  • specifically want an FDA-approved brand-name pen.
  • need to bill insurance — like most of this market, it's cash-pay.

Trust, safety, and medical oversight

We found no FDA warning letters on file for the provider. We explain how we weigh medical oversight and compliance in our scoring methodology.

Bottom line

MediRX earns its place on the shortlist mainly on price: at $149/month it's one of the more affordable ways to stay on a GLP-1, without obvious corners cut on access or oversight.

Ready to start with MediRX?

Starting at $149/month. See current pricing and start your free consultation.

Visit MediRX →

Sources

The primary regulatory filings and peer-reviewed studies cited throughout this MediRX review:

Sources & methodology — as of June 2026
  1. 1.Weight Loss Rankings — GLP-1 Pricing Index 2026 (our independent dataset)— WeightLossRankings.org.
  2. 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
  3. 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
  4. 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
  5. 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
  6. 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
  7. 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
  8. 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
  9. 9.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
  10. 10.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
  11. 11.FDA — Mounjaro (tirzepatide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
  12. 12.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.

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Frequently Asked Questions

Key terms, explained

New to GLP-1s? Tap any term for a quick, plain-English definition.

Ready to start with MediRX?

Starting at $149/month. See current pricing and start your free consultation.

Visit MediRX →