MediRX Review
Semaglutide & tirzepatide GLP-1 weight-loss telehealth · Independently scored 7.3/10
Best for: legitScript-certified compounded GLP-1 with low first-month promo pricing
Price is where MediRX scores best in our breakdown.
Semaglutide
Tirzepatide
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
No insurance needed · Vetted by our editors
MediRX is a telehealth weight-loss platform offering compounded GLP-1 injections — semaglutide starting at $149/month and tirzepatide starting at $199/month — plus NAD+ and a name-brand GLP-1 option. Care runs on OpenLoop Health: a licensed provider reviews your online intake and prescribes if appropriate, with fulfillment through OpenLoop's partnered U.S. licensed pharmacies. The site is LegitScript Certified and the operating entity, MediRX, Inc. of Wyoming, is disclosed, though it doesn't publish the exact states it serves.
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Vetted alternatives to MediRX
Telos Rx
Best for: Needle-free, microdosed compounded GLP-1 with lab-monitored care
Editorial score · methodology
Editorial score · methodology
RNK Health
Best for: compounded GLP-1 alongside NAD+, peptide and longevity add-ons
Editorial score · methodology
MediRX at a glance
- Type
- GLP-1 telehealth provider
- Medications
- Semaglutide from $149, Tirzepatide from $199
- Starting price
- $149/mo
- What's included
- Consult · Shipping · Medication
- FDA status
- No FDA warning letter on record
How we scored MediRX
Each dimension is scored algorithmically from MediRX’s real pricing, drugs offered, verification status, and disclosed inclusions — using the same six-dimension framework we apply to every provider.
Value25%
7.9/10At $149/mo, MediRX runs about 12% below the $169 median for GLP-1 providers.
Effectiveness25%
7.9/10MediRX offers both semaglutide and tirzepatide — the two GLP-1 molecules with the strongest published weight-loss trial outcomes.
User Experience15%
7.2/10Online intake and platform experience — consult included in the price; 8 platform features disclosed.
Trust & Safety15%
7.1/10Core details confirmed by our editors; no FDA warning letters on file (last checked 2026-08-15).
Accessibility10%
5.9/10MediRX's exact state footprint isn't published — confirm coverage in your state before signing up.
Support10%
5.7/10MediRX provides standard clinician follow-up; no extended coaching or community program is disclosed.
Providers that don’t post pricing up front score lower on Value and carry a cost-transparency note in their review. Read the full methodology →
How we verified this MediRX review
Last checked August 2026- Confirmed current pricing across 4 dose/plan tiers
- Confirmed what the monthly price does and doesn't include
- Checked the FDA warning-letter database for enforcement actions
- Walked the public intake/checkout flow on the provider's site
Pricing, availability, and compliance facts come from the provider's own site and primary regulatory records — see the sources below. Editorial confidence in this data: medium.
What to expect when you sign up with MediRX
We walked MediRX’s public signup flow in July 2026 to document the process — the steps, pricing transparency, and what’s required — before you commit. (We don’t create accounts, enter medical information, or check out; this is the observable funnel, not a prescribing outcome.)
- 1Choose your starting weight and browse GLP-1 product options (semaglutide or tirzepatide, injection or oral tablet) with prices shown on the homepage.
- 2Complete a quick online evaluation/assessment to determine whether GLP-1 medication is appropriate.
- 3A licensed OpenLoop provider reviews your information and determines if treatment is appropriate.
- 4If approved, the prescription is sent to a partner pharmacy.
- 5Medication is shipped directly and discreetly to your door with ongoing support from the care team.
- Offers semaglutide and tirzepatide in both injection and oral-tablet forms, with product prices (e.g., $129, $249) displayed before intake alongside a weight calculator.
- Advertises no membership fees, no insurance required, and free shipping.
- All medical services are provided exclusively by OpenLoop; prescriptions are at provider discretion and may not suit everyone.
- Some products are questionnaire-based while others require a live video or phone consultation before a prescription can be issued.
- Uses compounded medications; notes results, availability, and quantities may vary or be limited.
MediRX customer support
- Phone
- (307) 323-3550
- care@medirx.org
GLP-1 medications MediRX offers
Tap any medication to read our plain-English guide — how it works, dosing, side effects, and what the trials found.
Pricing
Prices re-verified
$149 to start, with $120 off a first month and as little as $70 for the first month on the 6-month plan. No insurance required. ⚠ MediRX's homepage also prints $179 for the same product in a second grid.
Ready to get started?
Plans and promotions change often — check MediRX's current pricing and active discounts before you decide.
What we like
- LegitScript Certified — a meaningful trust signal for an online pharmacy
- Named operating entity disclosed (MediRX, Inc., Wyoming)
- Care and pharmacy fulfillment run on OpenLoop Health's licensed network
- Low promotional first-month pricing — semaglutide first month as low as $70
Watch-outs
- Doesn't publish the exact states it serves; telehealth rules vary by state
- Ongoing monthly price rises after the promotional first month
- Compounded semaglutide and tirzepatide injections — limited oral options
- Specific compounding pharmacies aren't named beyond the OpenLoop network
Is MediRX worth it? Our verdict
MediRX positions itself around one thing: legitScript-certified compounded GLP-1 with low first-month promo pricing. It runs $149/month — toward the affordable end of the market.
MediRX rounds out its offering with Compounded GLP-1 injections, LegitScript Certified, and Powered by OpenLoop.
How much MediRX actually costs
- semaglutide — $149/month
- tirzepatide — $199/month
- semaglutide — $249/month
- tirzepatide — $279/month
That puts MediRX below the roughly $169 median ongoing price across the GLP-1 providers we track — a real cost advantage.
Gala (about $149/month) is one of the closest alternatives to weigh MediRX against.
Medications: what MediRX prescribes
MediRX prescribes semaglutide (the active drug in Wegovy and Ozempic) and tirzepatide (the active drug in Zepbound and Mounjaro) — the two most-studied weight-loss molecules on the market today.
Who MediRX is best for — and who should skip it
A good fit if you…
- are focused on the lowest ongoing monthly cost.
Look elsewhere if you…
- specifically want an FDA-approved brand-name pen.
- need to bill insurance — like most of this market, it's cash-pay.
Trust, safety, and medical oversight
We found no FDA warning letters on file for the provider. We explain how we weigh medical oversight and compliance in our scoring methodology.
Bottom line
MediRX earns its place on the shortlist mainly on price: at $149/month it's one of the more affordable ways to stay on a GLP-1, without obvious corners cut on access or oversight.
The Bottom Line
Price is where MediRX scores best in our breakdown.
Ready to start with MediRX?
Starting at $149/month. See current pricing and start your free consultation.
MediRX might not be your best fit if…
We rank editorially, so here’s where a different provider we track may serve you better.
- If you want brand-name Ozempic, Wegovy, Mounjaro or Zepbound, consider GobyMeds.
- If the lowest possible monthly price is your top priority, consider Sunlight (from $88/mo).
- If you want built-in coaching and behavior-change support, consider RNK Health.
Frequently Asked Questions
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Sources
The primary regulatory filings and peer-reviewed studies cited throughout this MediRX review:
Sources & methodology — as of September 2026
- 1.Weight Loss Rankings — GLP-1 Pricing Index 2026 (our independent dataset)— WeightLossRankings.org.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
- 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 9.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
- 10.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 11.FDA — Mounjaro (tirzepatide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 12.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.
See MediRX's current pricing
Plans start at $149/month. Start your free consultation to check eligibility and today's price.