Edessa Review
Semaglutide & tirzepatide GLP-1 weight-loss telehealth · Independently scored 7.3/10
Best for: cheap month-to-month compounded GLP-1 with tirzepatide and an oral tablet option
Edessa scores highest on state availability and ease of access.
Semaglutide
Tirzepatide
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
No insurance needed · Vetted by our editors
Edessa is a Las Vegas-based telehealth brand selling compounded semaglutide injections at $179/mo month-to-month (down to $135/mo on a six-month plan), a daily dissolvable semaglutide tablet from $229/mo and compounded tirzepatide from $239/mo. Care is delivered by OpenLoop Health clinicians and four named US compounding pharmacies, with medication, consult and expedited shipping in one cash-pay price and the same price at every dose.
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Vetted alternatives to Edessa
Editorial score · methodology
TMates
Best for: nationwide compounded GLP-1 availability including Puerto Rico
Editorial score · methodology
Editorial score · methodology
Edessa at a glance
- Type
- GLP-1 telehealth provider
- Medications
- Semaglutide, Tirzepatide
- Starting price
- $179/mo
- Pricing model
- Flat — dose increases don't raise the monthly price
- What's included
- Medication · Consult · Shipping
- Availability
- All 50 states
- FDA status
- No FDA warning letter on record
How we scored Edessa
Each dimension is scored algorithmically from Edessa’s real pricing, drugs offered, verification status, and disclosed inclusions — using the same six-dimension framework we apply to every provider.
Value25%
7.0/10At $179/mo, Edessa runs about 6% above the $169 median for GLP-1 providers. Pricing is flat across doses, so there is no escalation markup as you titrate up.
Effectiveness25%
8.0/10Edessa offers both semaglutide and tirzepatide — the two GLP-1 molecules with the strongest published weight-loss trial outcomes. An oral/needle-free option is offered for patients who avoid injections.
User Experience15%
7.2/10Online intake and platform experience — consult included in the price; 8 platform features disclosed.
Trust & Safety15%
7.1/10Core details confirmed by our editors; no FDA warning letters on file (last checked 2026-09-01).
Accessibility10%
8.5/10Edessa treats patients in all 50 states. FSA/HSA cards are accepted.
Support10%
5.7/10Edessa provides standard clinician follow-up; no extended coaching or community program is disclosed.
Providers that don’t post pricing up front score lower on Value and carry a cost-transparency note in their review. Read the full methodology →
How we verified this Edessa review
Last checked September 2026- Confirmed current pricing across 3 dose/plan tiers
- Confirmed availability in all 50 states
- Confirmed what the monthly price does and doesn't include
- Checked the FDA warning-letter database for enforcement actions
- Walked the public intake/checkout flow on the provider's site
Pricing, availability, and compliance facts come from the provider's own site and primary regulatory records — see the sources below. Editorial confidence in this data: medium.
What to expect when you sign up with Edessa
We walked Edessa’s public signup flow in September 2026 to document the process — the steps, pricing transparency, and what’s required — before you commit. (We don’t create accounts, enter medical information, or check out; this is the observable funnel, not a prescribing outcome.)
- 1Each product page publishes the whole ladder before intake: semaglutide injection $179 for one month, $160/mo on three, $135/mo on six; tablets $229/$209/$199; tirzepatide $239/$219/$209.
- 2The intake opens at 'Start' with height, weight and goal weight, and prints your BMI on the next screen before asking anything medical.
- 3'Preliminary' covers sex assigned at birth and pregnancy, breastfeeding and recent-birth screening, with a contraception notice for GLP-1 and tirzepatide patients.
- 4'Health' runs pace expectations, sleep quality and hours, then two long disqualifier screens (end-stage kidney and liver disease, pancreatitis, gallbladder disease, IBD, arrhythmias, thyroid history), allergies and prior GLP-1 use.
- 5'Details' asks about bariatric surgery, past weight-loss programs, willingness to change diet and activity, blood pressure and resting heart rate ranges, formulation preferences and date of birth.
- 6'Eligibility' shows a medical-review summary, then asks for first name, last name and the state your medication ships to before checkout. We stopped at that gate.
- Pricing is the clearest thing on the site: all three plan lengths are visible on every product page, and each one states 'Same price, every dose'.
- The banner price is the prepay price. '$135' is the six-month rate; the month-to-month rate is $179, and the FAQ describes $135 as a first-month price with no contract, which the plan table does not support.
- The intake summary declares 'a 94% chance of successful treatment if qualified' before any clinician has seen the answers.
- The Terms say an OpenLoop Health clinician meets you after checkout, so payment comes before the eligibility decision.
- The money-back guarantee in the Terms is much narrower than the banner: you must show no weight loss after at least five months on the program, and 25% is withheld for consult fees.
- The Terms have no auto-renewal or cancellation section, so how a plan renews or stops after a prepaid term is not disclosed anywhere we could find.
Edessa customer support
- Phone
- (270) 910-2233
- support@myedessa.com
GLP-1 medications Edessa offers
Tap any medication to read our plain-English guide — how it works, dosing, side effects, and what the trials found.
Pricing
Prices re-verified
Plan table on myedessa.com/product-glp-1-injection.html, verified 2026-09-01: 1 month $179, 3 month $160/mo, 6 month $135/mo. The homepage's 'Start for just $135' is the six-month prepay rate, not the month-to-month price.
1 month $229, 3 month $209/mo, 6 month $199/mo (myedessa.com/product-glp-1-tablet.html). 'Compounded semaglutide medication' is what the page says you receive.
1 month $239, 3 month $219/mo, 6 month $209/mo (myedessa.com/product-glp-1-tirzepatide.html).
Ready to get started?
Plans and promotions change often — check Edessa's current pricing and active discounts before you decide.
What we like
- Month-to-month compounded semaglutide at $179 with no contract, dropping to $135/mo on the six-month plan
- Tirzepatide and a daily dissolvable tablet sit alongside the standard weekly injection
- Every product page prints the 1-, 3- and 6-month rate side by side and states 'Same price, every dose'
- Medication, physician review, ongoing check-ins and free expedited cold-chain shipping are in the one price
- Four named US pharmacy partners with addresses (RedRock, Health Warehouse, Precision Compounding, Triad Rx)
- Care delivered through the OpenLoop Health licensed provider network, listed in all 50 states and DC
- Cash-pay with no insurance required, and HSA/FSA eligible
Watch-outs
- The advertised '$135' is the six-month prepay rate; month-to-month is $179, and the FAQ still calls $135 a first-month price 'with no contract'
- The 'no questions asked' guarantee is not the policy: the Terms need proof of no weight loss after five months, minus 25% consult fees
- The Terms also say all sales are final and consult fees are never refundable
- The Terms contain no auto-renewal or cancellation section, so what happens at the end of a prepaid term is not published
- You pay before the clinician review — an OpenLoop clinician meets you after checkout to decide whether you qualify
- Homepage figures (100,000+ patients, 18% average weight loss, 93% kept it off) carry no cited source
- No published support hours, and support is email and phone only
- Compounded GLP-1s are not FDA-approved
Is Edessa worth it? Our verdict
Edessa positions itself around one thing: cheap month-to-month compounded GLP-1 with tirzepatide and an oral tablet option. It runs $179/month, flat across every dose. Its standout is a needle-free oral option, which very few providers offer.
Where Edessa tries to set itself apart is the extras: Same Price Every Dose, All 50 States + DC, and HSA/FSA Eligible.
How much Edessa actually costs
- Compounded semaglutide — $179/month
- Compounded semaglutide — $229/month
- Compounded tirzepatide — $239/month
That's roughly in line with the ~$169/month median across the GLP-1 providers we track.
For a direct comparison, DudeMeds runs semaglutide and tirzepatide from $175/month — worth pricing against Edessa before you commit.
Medications: what Edessa prescribes
Edessa prescribes semaglutide (the active drug in Wegovy and Ozempic) and tirzepatide (the active drug in Zepbound and Mounjaro) — the two molecules with the strongest published weight-loss trial outcomes. Rather than brand-name pens, you get a compounded formulation from a licensed pharmacy — the reason the monthly cost is lower. Just know compounded drugs aren't FDA-approved as finished products, the standard caveat in this market.
Edessa's needle-free oral option is a real draw if you've been avoiding a GLP-1 because of injections. Just set expectations on the science: oral and buccal delivery of these peptides is far less studied than the injectable versions the trials used, so treat it as a convenience option rather than a proven equal to the shot.
Who Edessa is best for — and who should skip it
A good fit if you…
- are needle-averse and want a non-injectable option.
- live anywhere in the US and want guaranteed access.
Look elsewhere if you…
- specifically want an FDA-approved brand-name pen.
- need to bill insurance — like most of this market, it's cash-pay.
Trust, safety, and medical oversight
Edessa treats patients in all 50 states. We found no FDA warning letters on file for the provider. As with any compounded program, the most important step you can take is confirming which licensed pharmacy fills your prescription and what's in the formulation — we explain how in our scoring methodology.
Bottom line
Edessa is a reasonable telehealth GLP-1 option; weigh its pricing and coverage against the alternatives below before deciding. If you're comparison-shopping, Bodybuilding Health+ is one of the closest alternatives we track — worth a look before deciding.
The Bottom Line
Edessa scores highest on state availability and ease of access.
Ready to start with Edessa?
Starting at $179/month. See current pricing and start your free consultation.
Edessa might not be your best fit if…
We rank editorially, so here’s where a different provider we track may serve you better.
Frequently Asked Questions
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Sources
The primary regulatory filings and peer-reviewed studies cited throughout this Edessa review:
Sources & methodology — as of September 2026
- 1.Weight Loss Rankings — GLP-1 Pricing Index 2026 (our independent dataset)— WeightLossRankings.org.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
- 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 9.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
- 10.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 11.FDA — Mounjaro (tirzepatide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 12.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.
See Edessa's current pricing
Plans start at $179/month. Start your free consultation to check eligibility and today's price.