Rylo Health Review
Semaglutide & tirzepatide GLP-1 weight-loss telehealth · Independently scored 7.7/10
Best for: shoppers who want the pharmacy and medical group named before they buy
Price is where Rylo Health scores best in our breakdown.
Semaglutide
Tirzepatide
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
No insurance needed · Vetted by our editors
Texas telehealth selling compounded semaglutide and tirzepatide at one flat price per dose, $139 or $229 a month month-to-month and less on a quarterly plan, plus NAD+, sermorelin and glutathione. It names both its medical group and its dispensing pharmacy.
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Rylo Health at a glance
- Type
- GLP-1 telehealth provider
- Medications
- Semaglutide, Tirzepatide
- Starting price
- $139/mo
- Pricing model
- Flat: dose increases don't raise the monthly price
- What's included
- Medication · Consult · Shipping
- Availability
- All 50 states
- FDA status
- No FDA warning letter on record
How we scored Rylo Health
Each dimension is scored algorithmically from Rylo Health’s published pricing, drugs offered, verification status, and disclosed inclusions, using the same six-dimension framework we apply to every provider.
Value25%
8.3/10At $139/mo, Rylo Health runs about 22% below the $179 median for GLP-1 providers (each program's lowest listed ongoing monthly price for compounded semaglutide). Pricing is flat across doses, so there is no escalation markup as you titrate up.
Effectiveness25%
8.0/10Rylo Health offers both semaglutide and tirzepatide, the two GLP-1 molecules with the strongest published weight-loss trial outcomes.
User Experience15%
7.0/10Online intake and platform experience (consult included in the price); 4 platform features disclosed.
Trust & Safety15%
8.0/10Key details fully confirmed by our editors; no FDA warning letters on file.
Accessibility10%
8.1/10Rylo Health treats patients in all 50 states.
Support10%
5.7/10Rylo Health provides standard clinician follow-up; no extended coaching or community program is disclosed.
Each checked against the provider’s own site.
Providers that don’t post pricing up front score lower on Value and carry a cost-transparency note in their review. Read the full methodology →
How we verified this Rylo Health review
Last checked October 2026- Confirmed current pricing across 2 dose/plan tiers
- Confirmed availability in all 50 states
- Confirmed what the monthly price does and doesn't include
- Checked the FDA warning-letter database for enforcement actions
- Walked the public intake/checkout flow on the provider's site
Pricing, availability, and compliance facts come from the provider's own site and primary regulatory records. See the sources below. Editorial confidence in this data: high.
What we checked
- Provider's own pricing page
- $139–$229/mo across 2 dose/plan tiers (checked October 2026)
- FDA warning-letter register
- No letter on file for this provider
What to expect when you sign up with Rylo Health
We walked Rylo Health’s public signup flow in October 2026 to document the process (the steps, pricing transparency, and what’s required) before you commit. (We don’t create accounts, enter medical information, or check out; this is the observable funnel, not a prescribing outcome.)
- 1Homepage and product pages show monthly and quarterly prices before any intake
- 2Product page toggle switches between Monthly ($139 or $229) and Quarterly ($100 or $160 a month)
- 3See if I qualify opens Rylo Health's online intake
- 4First intake screen asks for your goal weight in pounds, where we stopped
- Walked the public funnel only: no account was created, no health information was submitted and no payment step was reached
- Pricing is clear: both the month-to-month and the quarterly price are on the product page, with the quarterly upfront charge stated
- The site says no lab work and no video call are needed; a physician reviews the questionnaire within 24 hours
- The pharmacy, VialsRX in Houston, and the medical group, Lone Star Virtual Health PLLC, are both named in the FAQ
- The Terms page is a short placeholder that says the full terms are being finalized, and it mentions membership fees the marketing says do not exist
- The footer badge reads LegitScript Certified but is a self-hosted image rather than the official LegitScript seal
Rylo Health customer support
- Phone
- (832) 945-0834
- hello@rylohealth.com
GLP-1 medications Rylo Health offers
Tap any medication to read our plain-English guide: how it works, dosing, side effects, and what the trials found.
Peptides Rylo Health offers
Beyond GLP-1s, Rylo Health also offers these peptides. Tap any for our evidence-based guide.
Pricing
Prices re-verified
$139/mo billed monthly, same price at every dose. Longer plans: 3-mo $100/mo ($299 every 3 months).
$229/mo billed monthly, same price at every dose. Longer plans: 3-mo $160/mo ($479 every 3 months).
Ready to get started?
Plans and promotions change often, so check Rylo Health's current pricing and active discounts before you decide.
What we like
- Names its dispensing pharmacy in full, with address and phone: VialsRX in Houston, Texas
- Names its medical group, Lone Star Virtual Health PLLC, and gives a provider contact
- Same price at every dose, with monthly and quarterly prices both shown before you start
- No membership fee on top of the medication price
- Cancel in one click from the patient portal, with no contracts and no cancellation fees
- Fully refundable any time before your first physician consultation
Watch-outs
- The headline $100 and $160 rates require paying for three months at once ($299 or $479)
- Shows a LegitScript badge that is a self-hosted image, not the official LegitScript seal
- Its Terms of Service say the full terms are still being finalized
- The Terms mention membership fees even though the site advertises no membership fee
- Refund rules after your first consultation are not spelled out
Is Rylo Health worth it?
Rylo Health built its program around one core idea: shoppers who want the pharmacy and medical group named before they buy. It runs $139/month at every dose, toward the affordable end of the category, so cost isn't the reason to look elsewhere. Its flat, all-dose pricing helps anyone worried about cost climbing as they titrate up.
How much Rylo Health costs
Compounded semaglutide runs $139/month and compounded tirzepatide runs $229/month.
That puts Rylo Health below the roughly $179 median across the GLP-1 providers we track (each program's lowest listed ongoing monthly price for compounded semaglutide), which is a cost advantage you can count on.
For a direct comparison, Live Vital runs semaglutide and tirzepatide from $130/month, so compare it with Rylo Health before you commit.
Medications: what Rylo Health prescribes
Rylo Health prescribes semaglutide (the active drug in Wegovy and Ozempic) and tirzepatide (the active drug in Zepbound and Mounjaro), the two most-studied weight-loss molecules on the market today. The medication is compounded at a licensed pharmacy rather than sold as a brand pen, which is what keeps the price down. The trade-off is the one every compounded provider shares: compounded drugs aren't FDA-approved as finished products.
Who Rylo Health is best for, and who should skip it
A good fit if you…
- are focused on the lowest ongoing monthly cost: $139/month is below the roughly $179 median we track across the category (each program's lowest listed ongoing monthly price).
- live anywhere in the US and want the certainty that your state is already covered.
Look elsewhere if you…
- specifically want an FDA-approved brand-name pen instead of a compounded formulation, which this provider doesn't fill.
- need to bill insurance, since like most of this market it's cash-pay with no claims filed on your behalf.
Trust, safety, and medical oversight
Rylo Health treats patients in all 50 states, and we found no FDA warning letter on file for it. As with any compounded program, the most important step you can take is confirming which licensed pharmacy fills your prescription and what's in the formulation, and we explain how in our scoring methodology.
Bottom line
Rylo Health earns its place on the shortlist mainly on price: at $139/month it's one of the more affordable ways to stay on a GLP-1, without obvious corners cut on access or oversight.
The Bottom Line
Price is where Rylo Health scores best in our breakdown.
Ready to start with Rylo Health?
From $139/mo. See current pricing and start your free consultation.
Rylo Health might not be your best fit if…
We rank editorially, so here’s where a different provider we track may serve you better.
Head-to-head
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Scores are our independent editorial ratings out of 10.
Frequently Asked Questions
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Sources
The primary regulatory filings and peer-reviewed studies cited throughout this Rylo Health review:
Sources & methodology (as of October 2026)
- 1.Weight Loss Rankings — GLP-1 Pricing Index 2026 (our independent dataset)— WeightLossRankings.org.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
- 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 9.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
- 10.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 11.FDA — Mounjaro (tirzepatide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 12.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.
See Rylo Health's current pricing
Plans from $139/mo. Start your free consultation to check eligibility and today's price.