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Tirzepatide in South Dakota: Best Providers & Prices (2026)

Compare 141 Tirzepatide telehealth providers available in South Dakota, sorted by cheapest monthly price.

Featured Partners · South Dakota

Featured Tirzepatide providers serving South Dakota

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  1. Top pick
    7.9
    Trimi Health

    Tirzepatide from

    $125/mo

    Save $961/mo vs Zepbound
    Get started →
  2. 8.1
    bmiMD

    Tirzepatide from

    $139/mo

    Save $947/mo vs Zepbound
    Get started →
  3. 8.1
    RxSpan MD

    Tirzepatide from

    $329/mo

    Save $757/mo vs Zepbound
    Get started →
  4. 8.0
    Strut Health

    Tirzepatide from

    $199/mo

    Save $887/mo vs Zepbound
    Get started →
  5. 7.6
    Sprout Health

    Tirzepatide from

    $199/mo

    Save $887/mo vs Zepbound
    Get started →
  6. 8.2
    Enhance MD

    Tirzepatide from

    $169/mo

    Save $917/mo vs Zepbound
    Get started →
See all 141 Tirzepatide providers serving South Dakota ↓

Tirzepatide providers[1]

141

Avg monthly cost[1]

$234

Savings vs Zepbound[3]

78%

State obesity rate[2]

33.2%

141 licensed telehealth providers ship compounded Tirzepatide to South Dakota addresses, with monthly prices averaging $234 — a roughly 78% discount to brand-name Zepbound at $1,086/month[3]. South Dakota's adult obesity rate of 33.2% (#21 nationally) has driven the state into one of the country's most active cash-pay GLP-1 markets.

South Dakota Medicaid & brand-name Zepbound: diabetes only[4]. Compounded tirzepatide is typically cash-pay — it isn't covered by Medicaid, Medicare, or commercial insurance in most cases. Brand-name Zepbound is generally FSA/HSA eligible with a prescription, and many plan administrators also accept compounded GLP-1s as an FSA/HSA expense with a Letter of Medical Necessity[5]. At the median compounded price, switching from brand-name Zepbound would save roughly $10,224/year out of pocket, with providers shipping statewide from Sioux Falls to smaller towns.

Sources & methodology — as of October 2026
  1. 1.Weight Loss Rankings — GLP-1 Pricing Index 2026 (our independent dataset)— WeightLossRankings.org.
  2. 2.CDC BRFSS — Adult Obesity Prevalence Maps by State (Behavioral Risk Factor Surveillance System)— Centers for Disease Control and Prevention.
  3. 3.LillyDirect — Zepbound self-pay program and cash price— Eli Lilly and Company (LillyDirect).
  4. 4.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
  5. 5.IRS Publication 502 — Medical and Dental Expenses (HSA/FSA eligibility)— Internal Revenue Service.

WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more

All Tirzepatide Providers Available in South Dakota

8.3/ 10
Verified partner

CoreAge Rx

Best for: best overall value

★★★★☆4.2/5

Editorial score · methodology

$99/mosemaglutide
$149/motirzepatide
CompoundedSemaglutideTirzepatideNAD+SermorelinLegitScript Verified
Get StartedRead full CoreAge Rx review →
8.3/ 10
Verified partner

Found

Best for: mainstream telehealth GLP-1 access

★★★★☆4.2/5

Editorial score · methodology

$99/mosemaglutide
$99/motirzepatide
CompoundedSemaglutideTirzepatideOrforglipron
Get StartedRead full Found review →
8.2/ 10
Verified partner

Gala

Best for: compounded GLP-1/GIP combo on a yearly plan with free shipping

★★★★☆4.1/5

Editorial score · methodology

$149/motirzepatide
CompoundedSemaglutideTirzepatideLegitScript Verified
Get StartedRead full Gala review →
7.8/ 10
Verified partner

Embody

Best for: low flat-rate compounded GLP-1 pricing at every dose

★★★★☆3.9/5

Editorial score · methodology

$79/mosemaglutide
$129/motirzepatide
CompoundedSemaglutideTirzepatideGlutathioneNAD+
Get StartedRead full Embody review →
7.7/ 10
Verified partner

Live Vital

Best for: low-cost, physician-led compounded GLP-1 with peptide and hormone options

★★★★☆3.9/5

Editorial score · methodology

$99/mosemaglutide
$183/motirzepatide
CompoundedSemaglutideTirzepatideBPC-157CJC-1295 / Ipamorelin
Get StartedRead full Live Vital review →
Browse all 141 Tirzepatide providers in South Dakota A–Z

Tirzepatide in South Dakota: The Numbers

The cheapest verified ongoing compounded Tirzepatide price available to South Dakota residents is $104/mo — verified against the provider's live pricing, not an advertised teaser. On the insured side, South Dakota Medicaid reimbursed approximately $2,439,627 across 2,260 Tirzepatide-class prescriptions in Q1 2026 (all covered indications, gross before rebates — full state series).

Tirzepatide in South Dakota: learn more

Tirzepatide Cost Breakdown in South Dakota

Brand-name Zepbound retails for about $1086/mo without insurance. Here's how much each Tirzepatide provider charges in South Dakota, and how much you save vs the brand cash price.

ProviderMin/moMax/moSavings vs Zepbound
Found$99$169Save $987/mo
MEDGm$99$399Save $987/mo
MEDVi$99$99Save $987/mo
Pillar Health$99.5$249Save $986.5/mo
Lavender Sky Health$105$105Save $981/mo
MaxLife$120$195Save $966/mo
Trimi Health$125$235Save $961/mo
Auren Rx$129$259Save $957/mo
Embody$129$329Save $957/mo
Jyra Health$133$133Save $953/mo
Cora Health$135$225Save $951/mo
EverSlim$136$136Save $950/mo
bmiMD$139$179Save $947/mo
Effecty$140$1400Save $946/mo
Fresh Day Meds$140$179Save $946/mo
NewSelf$144$225Save $942/mo
Alan Meds$145$295Save $941/mo
FMmeds$145$145Save $941/mo
Mondae$145$145Save $941/mo
Trava Health$147.33$178.98Save $938.67/mo
CoreAge Rx$149$149Save $937/mo
Curex$149$199Save $937/mo
Gala$149$179Save $937/mo
MyFastRx$149$249Save $937/mo
Revel Health$149$249Save $937/mo
TeleClinic$149$199Save $937/mo
Vitara RX$149$149Save $937/mo
He & She MD$159$299Save $927/mo
Vita Bella$159$159Save $927/mo
Gimme Care$163$199Save $923/mo
Big Easy Weight Loss$166$199.67Save $920/mo
Brello Health$166$197Save $920/mo
Ondra Health$166$219Save $920/mo
BioGlow Health$169$169Save $917/mo
Enhance MD$169$322Save $917/mo
Bon Health$170$170Save $916/mo
Fidelity Medical Clinic$174.5$378.25Save $911.5/mo
Aspen$179$179Save $907/mo
Get Thin MD$179$299Save $907/mo
Idgie Health$179$229Save $907/mo
NextMeds$179$179Save $907/mo
Pallas Health$179$299Save $907/mo
Luma Health Co$180$180Save $906/mo
Live Vital$183$239Save $903/mo
SurpassMD$184$184Save $902/mo
Navio MD$189$189Save $897/mo
Rewinding RX$189$189Save $897/mo
Tryozi$189$379Save $897/mo
Elara Health and Wellness$196$267Save $890/mo
Belle Health$199$199Save $887/mo
Care Bare Rx$199$199Save $887/mo
DoctorAdam$199$249Save $887/mo
InstaRX$199$199Save $887/mo
KERNX Health$199$199Save $887/mo
KIN Health$199$199Save $887/mo
Pepti$199$399Save $887/mo
Piper$199$199Save $887/mo
Precision Telemed$199$199Save $887/mo
Rivo Health$199$199Save $887/mo
Sprout Health$199$199Save $887/mo
StackMD$199$199Save $887/mo
Strut Health$199$199Save $887/mo
Trellis Vitality$199$199Save $887/mo
Trillium Meds$199$199Save $887/mo
Zera Health$199$199Save $887/mo
Vytora Health$200$249Save $886/mo
Midi Health$209$210Save $877/mo
The Edit$209$309Save $877/mo
Invyncible$210$210Save $876/mo
YourHealthRx$210$210Save $876/mo
PepHaūs$215$215Save $871/mo
PeterMD$215.67$215.67Save $870.33/mo
Ivologist$224$249Save $862/mo
Medro$224$224Save $862/mo
Curve$225$225Save $861/mo
Nouri$225$225Save $861/mo
Andrew Meds$229$299Save $857/mo
AVARA Rx$229$279Save $857/mo
Kongo$229$229Save $857/mo
Peak Wellness$229$349Save $857/mo
ZYP Medical$233$250Save $853/mo
DreamHug Medical$238$238Save $848/mo
Eden$238$298Save $848/mo
Coby Health$239$439Save $847/mo
Edessa$239$239Save $847/mo
Totara Health$239$239Save $847/mo
Vaylen$239$1086Save $847/mo
Wellorithm$247$347Save $839/mo
Bionomy Health$249$249Save $837/mo
GOAL.MD$249$249Save $837/mo
NuBloom$249$279Save $837/mo
PlexusDx$249$249Save $837/mo
Rylo Health$249$249Save $837/mo
Tyde Wellness$249$249Save $837/mo
Rebody Health$249.99$573.99Save $836.01/mo
LifespanningRx$250$351.5Save $836/mo
Medsol RX$250$250Save $836/mo
NP2GO$250$600Save $836/mo
Yucca Health$258$258Save $828/mo
REMEVi$269$269Save $817/mo
Renlo Health$269$269Save $817/mo
Ivy Rx$275$275Save $811/mo
Joey Med$275$599Save $811/mo
LifeRx.md$275$275Save $811/mo
Welling Health$275$275Save $811/mo
EOS Health$279.99$379.99Save $806.01/mo
Rx.com$285$285Save $801/mo
Amble$289$289Save $797/mo
Brightmeds$289$289Save $797/mo
ReadyRx$295$315Save $791/mo
Fierce Health$297$497Save $789/mo
TMates$297$297Save $789/mo
AskRx$299$449Save $787/mo
BetterMe Rx$299$299Save $787/mo
Breeze Meds$299$399Save $787/mo
EdgeRx$299$299Save $787/mo
GoodRx$299$299Save $787/mo
Heally$299$299Save $787/mo
HealthSource$299$399Save $787/mo
Hers$299$1899Save $787/mo
Hims$299$299Save $787/mo
HumeCare+$299$299Save $787/mo
Knownwell$299$299Save $787/mo
Longevixx$299$299Save $787/mo
NiceRx$299$299Save $787/mo
Semaglutide Online$299$299Save $787/mo
WeightWatchers Clinic$299$299Save $787/mo
Zappy Health$299$299Save $787/mo
Rixa Health$303.33$303.33Save $782.6700000000001/mo
RxSpan MD$329$1069Save $757/mo
Fitish$339$339Save $747/mo
Synergy Rx$349$947Save $737/mo
Maximus$359.99$359.99Save $726.01/mo
Independent Wellness$379$379Save $707/mo
Apex MD$399$419Save $687/mo
PlushCare$399$399Save $687/mo
RestorLife Med$399$399Save $687/mo
TeleCareSpot$399$399Save $687/mo
Revive Meds$459$459Save $627/mo
VirtualCare2Go$629$629Save $457/mo
Levity$1249$1299—

South Dakota Coverage & Regulations

South Dakota Medicaid GLP-1 Coverage
Diabetes only

South Dakota allows telehealth GLP-1 prescribing. South Dakota Medicaid covers GLP-1s only for type 2 diabetes diagnosis.

Top South Dakota cities for Tirzepatide telehealth:
Sioux FallsRapid CityAberdeenBrookings

Frequently Asked Questions

Compounded Tirzepatide in South Dakota averages around $234 per month through licensed telehealth providers. Brand-name Zepbound typically costs about $1086 per month without insurance. The cheapest cash-pay Tirzepatide option in South Dakota starts around $99/mo.
Yes. Tirzepatide is FDA-approved and legal to prescribe in South Dakota. Compounded Tirzepatide is also legal when dispensed by a licensed 503A or 503B pharmacy under a valid prescription from a South Dakota-licensed clinician. Telehealth visits for GLP-1 prescriptions are explicitly permitted statewide.
South Dakota Medicaid coverage for GLP-1 weight-loss medication is currently: Diabetes only. Brand-name Mounjaro is generally covered for type 2 diabetes, while obesity-only indications (Zepbound) typically require prior authorization or are not covered. Compounded Tirzepatide is a cash-pay option and is not covered by Medicaid in any state.
Residents of South Dakota can get Tirzepatide through 141 licensed telehealth providers that ship to all major South Dakota cities including Sioux Falls, Rapid City, Aberdeen. Local in-person clinics and compounding pharmacies are also available, but telehealth is typically faster and cheaper.
The lowest-priced Tirzepatide provider currently serving South Dakota is Found at approximately $99/mo. Pricing changes frequently — see the provider grid above for current promotions and dose-by-dose cost.
We track 141 telehealth Tirzepatide providers that ship to South Dakota addresses. Use the "Best value," "Most affordable," and "Most expensive" filters on the provider list above to sort them, or open the A–Z index to see the full list.
Both are available to South Dakota residents through telehealth. Tirzepatide (Zepbound) produced greater average weight loss than semaglutide in the head-to-head SURMOUNT-5 trial (about 20% vs 14%), but it typically costs more. Compare the trial results and both provider lists before deciding.

Key terms, explained

New to GLP-1s? Tap any term for a quick, plain-English definition.

Related Pages

See all GLP-1 providers in South Dakota →
Every weight-loss provider serving South Dakota, not just Tirzepatide.
Semaglutide in South Dakota →
Compare Semaglutide pricing and providers in South Dakota.
Tirzepatide pricing in other states:
Tirzepatide in AlabamaTirzepatide in AlaskaTirzepatide in ArizonaTirzepatide in ArkansasTirzepatide in California
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