Is Tirzepatide FDA-approved?

FDA-approved for type 2 diabetes as Mounjaro (2022); FDA-approved for chronic weight management as Zepbound (2023)

How much does Tirzepatide cost?

Tirzepatide costs vary significantly by provider and form. Brand-name versions can cost $1,000–$1,600/month without insurance. Compounded versions from telehealth providers typically range from $129–$400/month. See the cost comparison table above for current prices from top providers. Always check for manufacturer savings programs or telehealth promo codes.

Where can I get Tirzepatide?

Tirzepatide requires a prescription from a licensed healthcare provider. You can get it through your primary care doctor, endocrinologist, or a telehealth platform. Telehealth providers like those listed above typically offer faster access and lower out-of-pocket costs than traditional pharmacies for compounded versions.

✅FDA Reviewed📅Updated April 6, 2026

Tirzepatide Guide

Tirzepatide is a first-in-class dual GIP/GLP-1 receptor agonist that activates two incretin hormone pathways simultaneously. It is FDA-approved for type 2 diabetes as Mounjaro and for chronic weight management as Zepbound, and has demonstrated superior weight loss outcomes compared to semaglutide in head-to-head trials.

WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more

At a Glance

Generic Name	Tirzepatide
Brand Names	Mounjaro, Zepbound
FDA Status	FDA-approved for type 2 diabetes as Mounjaro (2022); FDA-approved for chronic weight management as Zepbound (2023)
Approval Date	November 8, 2023

How Tirzepatide Works

Tirzepatide is a "twincretin" that activates both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 receptors. GLP-1 activation reduces appetite and slows gastric emptying, while GIP activation enhances insulin secretion, reduces glucagon, and may also act directly on fat tissue to improve metabolism. This dual mechanism produces greater weight loss than GLP-1-only agents like semaglutide.

Dosing Schedule

Tirzepatide uses a gradual dose escalation to minimize side effects. Always follow your prescriber's guidance.

Weeks 1–42.5mg/week

Weeks 5–85mg/week

Weeks 9–127.5mg/week

Weeks 13–1610mg/week

Weeks 17–2012.5mg/week

Week 21+15mg/week (max maintenance)

Side Effects

Common: nausea, diarrhea, vomiting, constipation, abdominal pain, decreased appetite, injection site reactions, fatigue. Serious (rare): pancreatitis, gallbladder problems, hypoglycemia (especially with insulin), kidney problems, increased heart rate. Same thyroid tumor precautions as semaglutide apply.

This is not a complete list. Consult your healthcare provider or prescriber for full safety information.

Clinical Trial Results

In the SURMOUNT-1 trial (N=2,539), tirzepatide at the 15mg dose achieved an average weight loss of 22.5% over 72 weeks — nearly double the results seen with semaglutide. Participants on 10mg lost an average of 21.4%, and those on 5mg lost 15.0%, all versus 2.5% placebo.
Source: Published clinical trial data (STEP / SURMOUNT trial series)

Where to Get Tirzepatide

These telehealth providers offer access to tirzepatide or compounded equivalents with online consultations and home delivery.

CoreAge Rx

Best for: best overall value

9.0

★★★★★4.7 (850)

$149/mo

CompoundedFree 2-Day Shipping24/7 SupportLegitScript Verified

Get Started