Rx.com Review
Semaglutide & tirzepatide GLP-1 weight-loss telehealth · Independently scored 7.6/10
Best for: month-to-month compounded GLP-1s at one flat price per dose, with the pharmacy named
Rx.com scores highest on state availability and ease of access.
Semaglutide
Tirzepatide
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
No insurance needed · Vetted by our editors
Rx.com, a San Antonio-based prescription-savings and online-care site, now runs its own GLP-1 program: compounded semaglutide at $175/mo or tirzepatide at $285/mo on a one-month plan, with lower monthly rates on three- and six-month plans paid upfront. One price covers the provider visit, medication at any dose, supplies and shipping. Care comes through the MD Integrations provider network, and Manifest Pharmacy in South Carolina fills prescriptions.
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Vetted alternatives to Rx.com
Editorial score · methodology
Editorial score · methodology
Editorial score · methodology
Rx.com at a glance
- Type
- GLP-1 telehealth provider
- Medications
- Semaglutide, Tirzepatide
- Starting price
- $175/mo
- Pricing model
- Flat — dose increases don't raise the monthly price
- What's included
- Medication · Consult · Shipping
- Availability
- 49 states
- FDA status
- No FDA warning letter on record
How we scored Rx.com
Each dimension is scored algorithmically from Rx.com’s real pricing, drugs offered, verification status, and disclosed inclusions — using the same six-dimension framework we apply to every provider.
Value25%
7.8/10At $175/mo, Rx.com runs in line with the $170 median for GLP-1 providers. Pricing is flat across doses, so there is no escalation markup as you titrate up.
Effectiveness25%
8.0/10Rx.com offers both semaglutide and tirzepatide — the two GLP-1 molecules with the strongest published weight-loss trial outcomes.
User Experience15%
7.3/10Online intake and platform experience — consult included in the price; 8 platform features disclosed.
Trust & Safety15%
7.9/10Core details confirmed by our editors; no FDA warning letters on file; dispenses through an accredited compounding pharmacy.
Accessibility10%
8.2/10Rx.com treats patients in all 50 states.
Support10%
5.8/10Rx.com provides standard clinician follow-up; no extended coaching or community program is disclosed.
Providers that don’t post pricing up front score lower on Value and carry a cost-transparency note in their review. Read the full methodology →
How we verified this Rx.com review
Last checked September 2026- Confirmed current pricing across 2 dose/plan tiers
- Confirmed availability in all 50 states
- Confirmed what the monthly price does and doesn't include
- Checked the FDA warning-letter database for enforcement actions
- Walked the public intake/checkout flow on the provider's site
Pricing, availability, and compliance facts come from the provider's own site and primary regulatory records — see the sources below. Editorial confidence in this data: medium.
What to expect when you sign up with Rx.com
We walked Rx.com’s public signup flow in September 2026 to document the process — the steps, pricing transparency, and what’s required — before you commit. (We don’t create accounts, enter medical information, or check out; this is the observable funnel, not a prescribing outcome.)
- 1Prices come first: the weight-loss page shows semaglutide and tirzepatide with 1-, 3- and 6-month plans and the total for each before you answer a single question.
- 2The quiz asks your main goal, then which healthy changes you are willing to make, then shows a short explainer on how GLP-1 medications work.
- 3You enter height and weight (your BMI is calculated on screen; the cutoff is 27), then a goal weight, then see a projected-loss chart.
- 4Date of birth (18 or older), sex at birth, then your state. Alaska is the only state the quiz turns away.
- 5Name, email and phone come next, with a required checkbox that accepts the terms and consents to marketing calls and texts in one tick.
- 6A results screen says you pre-qualify and repeats the plan picker, with a 'Continue to secure checkout' button.
- 7Checkout, on checkout.rx.com, takes your email and shipping address and then asks for a card. We stopped at the card form. The medical questionnaire and photo ID come after payment.
- You pay before any clinician sees your history: the charge happens at checkout, and the medical intake and ID check follow. The written promise is a full refund if the provider does not prescribe.
- The plan cards say 'one payment' and 'No automatic renewals', yet the order summary hides a disclaimer, visible only when you expand 'Your total', that says billing 'will continue' every 28 days until you email rxsupport@rx.com. We could not confirm which is true without paying.
- On the six-month plans that same disclaimer describes a '1 month supply' and says billing continues at the full $875 or $1,550 'per month after the first 28 days', which looks like a one-month template applied to every plan.
- The checkout lists 'Doctor Support and Monitoring $99' and 'Overnight Shipping $40', both struck through to 'free'. The refund policy separately quotes delivery at 3 to 7 business days.
- The projection chart places the 68- and 72-week clinical-trial averages (about 32 lb and 44 lb at our test weight) at 'Month 6' on its timeline.
- An older Weight Loss Program page, still linked from the results screen, lists $179.99 for the first month and $279.99/mo after for compounded GLP-1, and $279.99 then $379.99 for GLP-1 + GIP.
- Rx.com also runs a separate comparison page that ranks another company's GLP-1 program first, at the same 'from $146/mo' figure, through affiliate links.
- No phone number for Rx.com appears anywhere. The terms give support@rx.com with weekday hours, the checkout disclaimer gives rxsupport@rx.com, and the only phone number published belongs to the pharmacy.
Rx.com customer support
- support@rx.com
- Hours
- Monday to Friday, 8am to 5pm Eastern (email). No phone number published.
GLP-1 medications Rx.com offers
Tap any medication to read our plain-English guide — how it works, dosing, side effects, and what the trials found.
Pricing
Prices re-verified
'1 month $175 per month'. Longer plans are one upfront charge: 3 months $495 ($165/mo), 6 months $875 ($146/mo). Checkout fine print says billing continues every 28 days.
'1 month $285 per month'. Longer plans are one upfront charge: 3 months $795 ($265/mo), 6 months $1,550 ($259/mo). Checkout fine print says billing continues every 28 days.
Ready to get started?
Plans and promotions change often — check Rx.com's current pricing and active discounts before you decide.
What we like
- Prices are posted before any intake: semaglutide $175/mo and tirzepatide $285/mo month to month, the same at every dose
- Names its dispensing pharmacy (Manifest Pharmacy, Greer, SC) and its provider network (MD Integrations)
- One price covers the provider visit, follow-ups, medication, syringes, alcohol pads and shipping
- No membership, visit, dose-upcharge or shipping fees
- Six-month plans lower the rate to $146/mo for semaglutide and $259/mo for tirzepatide, paid as one charge
- Full refund if the provider decides treatment is not right for you
- Displays a LegitScript seal served from LegitScript's own servers, not a self-hosted image
- Serves 49 states; Alaska is the only state turned away
Watch-outs
- Plan pages promise 'No automatic renewals,' but the checkout fine print says billing continues every 28 days
- On six-month plans that checkout text reads as if the full $875 or $1,550 repeats monthly, an apparent template error
- A second program page still lists older prices ($179.99 first month, then $279.99/mo) that don't match the plan picker
- Medication sales are final once shipped, and no policy covers unshipped months if you cancel a prepaid plan
- No phone number is published, though checkout promises '24/7 support via email or phone'
- The refund policy says Rx.com does not ship refrigerated products, while the program promises cold-packed shipping
- New program with almost no outside review history: its Trustpilot profile has a single review
- Compounded semaglutide and tirzepatide are not FDA-approved
Is Rx.com worth it? Our verdict
Rx.com positions itself around one thing: month-to-month compounded GLP-1s at one flat price per dose, with the pharmacy named. It runs $175/month, flat across every dose. Its flat, all-dose pricing is a genuine plus for anyone worried about cost climbing as they titrate up.
Rx.com rounds out its offering with LegitScript Verified, No Membership Fee, and 503A Pharmacy.
How much Rx.com actually costs
- Compounded semaglutide — $175/month
- Compounded tirzepatide — $285/month
That's roughly in line with the ~$170/month median across the GLP-1 providers we track.
For a direct comparison, Enhance MD runs semaglutide and tirzepatide from $169/month — worth pricing against Rx.com before you commit.
Medications: what Rx.com prescribes
Rx.com prescribes semaglutide (the active drug in Wegovy and Ozempic) and tirzepatide (the active drug in Zepbound and Mounjaro) — the pair backed by the largest published weight-loss trials. The medication is compounded at a licensed pharmacy rather than sold as a brand pen, which is what keeps the price down. The trade-off is the one every compounded provider shares: compounded drugs aren't FDA-approved as finished products.
Who Rx.com is best for — and who should skip it
A good fit if you…
- live anywhere in the US and want guaranteed access.
Look elsewhere if you…
- specifically want an FDA-approved brand-name pen.
- need to bill insurance — like most of this market, it's cash-pay.
Trust, safety, and medical oversight
Rx.com treats patients in all 50 states, and dispenses through an accredited compounding pharmacy. We found no FDA warning letters on file for the provider. As with any compounded program, the most important step you can take is confirming which licensed pharmacy fills your prescription and what's in the formulation — we explain how in our scoring methodology.
Bottom line
Rx.com is a reasonable telehealth GLP-1 option; weigh its pricing and coverage against the alternatives below before deciding. If you're comparison-shopping, DudeMeds is one of the closest alternatives we track — worth a look before deciding.
The Bottom Line
Rx.com scores highest on state availability and ease of access.
Ready to start with Rx.com?
Starting at $175/month. See current pricing and start your free consultation.
Rx.com might not be your best fit if…
We rank editorially, so here’s where a different provider we track may serve you better.
Frequently Asked Questions
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Sources
The primary regulatory filings and peer-reviewed studies cited throughout this Rx.com review:
Sources & methodology — as of September 2026
- 1.Weight Loss Rankings — GLP-1 Pricing Index 2026 (our independent dataset)— WeightLossRankings.org.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
- 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 9.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
- 10.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 11.FDA — Mounjaro (tirzepatide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 12.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.
See Rx.com's current pricing
Plans start at $175/month. Start your free consultation to check eligibility and today's price.