Silhouette MD Review

Is Silhouette MD worth it?

The short version of what Silhouette MD offers is hands-on concierge support alongside compounded GLP-1 treatment. It runs $149/month (“starting at” price). That is a qualified figure, not a plain month-to-month price, so we don't rank it against the category median; the cost section below says what it covers. Its standout is a needle-free oral option for people who would rather not inject.

Silhouette MD offers a concierge-style service tier.

How much Silhouette MD costs

Compounded semaglutide runs $149–$263/month depending on plan, the low end a “starting at” price, and compounded tirzepatide runs $299–$325/month depending on plan, the low end a “starting at” price.

Because Silhouette MD's headline figure is a “starting at” price, we don't set it against the roughly $179 market median for this category. That median is each program's lowest listed ongoing monthly price for compounded semaglutide, so compare Silhouette MD with the month-to-month prices of the alternatives below instead.

PlexusDx (about $149/month) is one of the closest alternatives to weigh Silhouette MD against.

Medications: what Silhouette MD prescribes

Silhouette MD prescribes semaglutide (the active drug in Wegovy and Ozempic) and tirzepatide (the active drug in Zepbound and Mounjaro), the two molecules with the strongest published weight-loss trial outcomes. Rather than brand-name pens, you get a compounded formulation from a licensed pharmacy, which is why the monthly cost is lower. Just know compounded drugs aren't FDA-approved as finished products, the standard caveat in this market.

Silhouette MD's needle-free oral option appeals if you've been avoiding a GLP-1 because of injections. Just set expectations on the science: oral, sublingual and buccal delivery of these peptides is far less studied than the injectable versions the trials used. Treat it as a convenience option, not a proven equal to the shot.

Who Silhouette MD is best for, and who should skip it

A good fit if you…

• are needle-averse and want a non-injectable option, since the oral route skips the weekly injection most GLP-1 programs require.

Look elsewhere if you…

• specifically want an FDA-approved brand-name pen instead of a compounded formulation, which this provider doesn't fill.
• need to bill insurance, since like most of this market it's cash-pay with no claims filed on your behalf.

Trust, safety, and medical oversight

We found no FDA warning letter on file for it, though a clean record isn't the same as an endorsement, so read the rest of this review for the full picture. As with any compounded program, the most important step you can take is confirming which licensed pharmacy fills your prescription and what's in the formulation, and we explain how in our scoring methodology.

Bottom line

Silhouette MD is a reasonable telehealth GLP-1 option; weigh its pricing and coverage against the alternatives below before deciding. To see Silhouette MD against the wider field, use our ranking of semaglutide providers; the patient guide to compounded versus brand-name GLP-1s covers what to weigh before choosing a compounded program.