Cost Plus Drugs Review
Best for: the cheapest transparent-pricing brand-name Ozempic channel
Mark Cuban's transparent-pricing online pharmacy. Sells branded Ozempic at the wholesale acquisition cost plus 15% markup plus a flat $5 pharmacy fee — publicly disclosed margin formula. Pharmacy fulfillment only; no telehealth intake. Ships to all 50 states. Distinct from telehealth platforms that route brand-name semaglutide through similar discount channels.
Medium confidence · Last verified 2026-05-09 via manual · How we verify provider data
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The Bottom Line
Cost Plus Drugs is one of the most affordable GLP-1 options on the market.
Score Breakdown
Drugs Offered
Cost Plus Drugs prescribes the following GLP-1 medications. Tap a drug to read our clinical guide with FDA label info, dosing schedules, side effects, and trial data.
Pricing
| Dose | Form | Price/mo |
|---|---|---|
| Ozempic (branded, WAC + 15% + $5 pharmacy fee) | brand | $279 |
✓ Pros
- •Transparent pricing formula: wholesale acquisition cost + 15% markup + $5 pharmacy fee — publicly disclosed and the same for everyone (no insurance gatekeeping, no negotiated PBM rebate games)
- •~$279/month for branded Ozempic is meaningfully below retail pharmacy list prices for the same FDA-approved manufacturer product
- •Mark Cuban's PBM-disrupting platform has earned editorial credibility from Forbes Health, Wired, and KFF Health News for its pricing transparency
- •Ships to all 50 states; same FDA-approved Novo Nordisk Ozempic, no compounded reformulation
- •Partnered with 9amHealth for telehealth prescribing — you can get the prescription separately and pay Cost Plus pricing for fulfillment
✗ Cons
- •Pharmacy fulfillment only — no telehealth intake, no prescribing clinicians on staff. You need a valid Ozempic prescription from an external clinician (PCP, endocrinologist, or telehealth provider) before Cost Plus can fill it
- •Ozempic is FDA-indicated for type 2 diabetes, not chronic weight management — your prescribing clinician's documentation matters for off-label weight-loss use
- •Wegovy availability through Cost Plus has historically been spotty — verify current Wegovy SKU status before assuming it ships
- •No compounded semaglutide or tirzepatide — brand-only model
- •No clinical follow-up included — fulfillment-only model means side-effect monitoring is on your prescribing clinician
Ready to start with Cost Plus Drugs?
Starting at $279/month. See current pricing and start your free consultation.
Sources & methodology
Our Cost Plus Drugs review applies the same 6-dimension scoring framework we use for every provider. Pricing, FDA approval status, compounding rules, and clinical-trial efficacy claims are sourced from the primary regulatory and peer-reviewed literature below.
Sources & methodology — as of May 2026
- 1.Weight Loss Rankings — GLP-1 Pricing Index 2026 (our independent dataset)— WeightLossRankings.org.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
- 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
Alternatives to Cost Plus Drugs
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Frequently Asked Questions
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Ready to start with Cost Plus Drugs?
Starting at $279/month. See current pricing and start your free consultation.