Best Weight Loss Shots in 2026 — Ranked & Reviewed
“Weight loss shots” almost always means GLP-1 injections: semaglutide (sold as Wegovy and Ozempic, and as compounded semaglutide) and tirzepatide (Zepbound, Mounjaro, and compounded tirzepatide). Older options like B12, lipotropic (MIC), and HCG shots have no comparable weight-loss evidence — the shots that work are the GLP-1s. Below: what each shot is called, what it actually costs per month, and the ranked telehealth providers that prescribe them online.
Lowest verified price: $25/mo465 providers compared
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
465 weight loss shots compared · independently scored against our six-factor methodology.
Compare the top providers at a glance
Logos, our editorial rating, price, medications, and coverage — the fastest way to narrow the list.
- ★ Editor's Pick
mainstream telehealth GLP-1 access
From /mo$99Coverage50 statesMedicationsSemaglutideTirzepatide - Nationwide Coverage
best overall value
From /mo$99Flat at every doseCoverage50 statesMedicationsSemaglutideTirzepatide lab-monitored compounded GLP-1 with mandatory video visit
From /mo$112Flat at every doseCoverage39 statesMedicationsSemaglutideTirzepatidecompounded GLP-1/GIP combo on a yearly plan with free shipping
From /mo$149Flat at every doseCoverage50 statesMedicationsTirzepatideSemaglutidemainstream telehealth GLP-1 access
From /mo$99Flat at every doseCoverage50 statesMedicationsSemaglutideTirzepatide- Transparent Pricing
the most complete public disclosure of pharmacies and prescribing physicians we have found
From /mo$139Flat at every doseCoverage50 statesMedicationsSemaglutideTirzepatide physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
From /mo$179Coverage50 statesMedicationsSemaglutideTirzepatide- Best Budget
budget-conscious shoppers
From /mo$93CoverageCheck intakeMedicationsSemaglutideTirzepatide
| Provider | Rating | From /mo | Medications | Coverage | |
|---|---|---|---|---|---|
★ Editor's Pick mainstream telehealth GLP-1 access | $99 | SemaglutideTirzepatide | 50 states | Visit → | |
Nationwide Coverage best overall value | $99 Flat pricing | SemaglutideTirzepatide | 50 states | Visit → | |
 lab-monitored compounded GLP-1 with mandatory video visit | $112 Flat pricing | SemaglutideTirzepatide | 39 states | Visit → | |
 compounded GLP-1/GIP combo on a yearly plan with free shipping | $149 Flat pricing | TirzepatideSemaglutide | 50 states | Visit → | |
 mainstream telehealth GLP-1 access | $99 Flat pricing | SemaglutideTirzepatide | 50 states | Visit → | |
Transparent Pricing the most complete public disclosure of pharmacies and prescribing physicians we have found | $139 Flat pricing | SemaglutideTirzepatide | 50 states | Visit → | |
 physician-led, pharmacy-transparent compounded GLP-1 with brand-name options | $179 | SemaglutideTirzepatide | 50 states | Visit → | |
Best Budget budget-conscious shoppers | $93 | SemaglutideTirzepatide | Check intake | Visit → |
Providers that don’t post pricing up front score lower on Value and carry a cost-transparency note in their review. Read the full methodology →
Names of weight loss shots, and which ones actually work
When people search “weight loss shots,” they almost always mean the GLP-1 injections: semaglutide (sold as Wegovy and Ozempic) and tirzepatide (Zepbound and Mounjaro), plus the lower-cost compounded versions. Older injectables marketed for weight loss — B12, lipotropic (MIC), and HCG shots — have no comparable evidence. Here is every shot by name, what is actually in it, and whether the data supports it.
GLP-1 shots — the ones with trial evidence
| Shot | Active ingredient | Class | Typical result | Verdict |
|---|---|---|---|---|
| Wegovy | semaglutide | GLP-1 | ~15% body weight (STEP-1, 68 wk) | Evidence-backed |
| Zepbound | tirzepatide | GLP-1 / GIP | ~21% body weight (SURMOUNT-1, 72 wk) | Evidence-backed |
| Ozempic | semaglutide | GLP-1 | Same molecule as Wegovy (diabetes label) | Evidence-backed |
| Mounjaro | tirzepatide | GLP-1 / GIP | Same molecule as Zepbound (diabetes label) | Evidence-backed |
| Saxenda | liraglutide | GLP-1 | ~8% body weight (SCALE, daily shot) | Evidence-backed |
| Compounded semaglutide / tirzepatide | semaglutide / tirzepatide | GLP-1 | Same active ingredient; lower cash cost | Evidence-backed |
Older “weight loss shots” — no comparable evidence
| Shot | Active ingredient | Class | Typical result | Verdict |
|---|---|---|---|---|
| B12 (cyanocobalamin) shots | vitamin B12 | Vitamin | No weight-loss effect unless B12-deficient | No evidence |
| Lipotropic / MIC shots | methionine, inositol, choline | Amino/lipotropic | No controlled evidence of fat loss | No evidence |
| HCG shots | human chorionic gonadotropin | Hormone | FDA: no evidence; banned for weight loss claims | No evidence |
B12 shots only help weight indirectly, and only if you are genuinely B12-deficient. Lipotropic/MIC shots have no controlled trials showing fat loss. The FDA has stated there is no substantial evidence that HCG causes weight loss and prohibits weight-loss claims for it. If a clinic sells these as a weight-loss shot, treat it as a red flag. Full breakdown: do B12, lipotropic (MIC), and HCG shots work. And because the GLP-1s themselves are peptides, see peptide shots for weight loss.
Ready to compare the GLP-1 shots that work? The ranked providers above prescribe them online. For the medication side, read our semaglutide and tirzepatide guides, or compare them head-to-head in best weight loss injections.
Detailed Reviews
Found
Verified partnerBest for: mainstream telehealth GLP-1 access
Personalized weight care platform with a self-pay membership model plus medication costs.
Score Breakdown
Pros
- ✓Aggressively low monthly pricing
- ✓Both semaglutide and tirzepatide available
- ✓Compounded GLP-1 access
Cons
- ✗Limited public information on program details
CoreAge Rx
Verified partnerBest for: best overall value
CoreAge Rx offers LegitScript-verified compounded semaglutide and tirzepatide with free 2-day shipping to all 50 states. Backed by licensed physicians and 24/7 support, it delivers the most competitive pricing in the compounded GLP-1 space.
Score Breakdown
Pros
- ✓LegitScript certified — rigorous pharmacy standards
- ✓Free 2-day shipping nationwide
- ✓Both semaglutide and tirzepatide available
- ✓Lowest per-month pricing in the compounded segment
- ✓24/7 support team
- ✓All 50 states covered
Cons
- ✗Compounded only — no brand-name Ozempic or Wegovy
- ✗Newer brand with fewer independent reviews than legacy players
Enhance MD
Verified partnerBest for: lab-monitored compounded GLP-1 with mandatory video visit
Enhance MD pairs compounded semaglutide and tirzepatide with mandatory baseline metabolic labs at Quest Diagnostics and a synchronous video visit with a board-certified clinician — a more rigorous onboarding than the async-only compounded GLP-1 model most telehealth providers use. Three tiers (Core semaglutide, Advanced tirzepatide, Elite combined) plus $100-off-first-order intro pricing ($112 first month on Core with code SUMMER100).
Score Breakdown
Pros
- ✓Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- ✓Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- ✓Three tiers, including a combined semaglutide + tirzepatide Elite plan ($322/mo) for patients plateaued on one GLP-1
- ✓Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
- ✓Intro pricing via $100 off your first order (code SUMMER100): $112 Core, $180 Advanced, $222 Elite first month
- ✓Unlimited clinician messaging and dose-adjustment support included
Cons
- ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- ✗Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- ✗Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
- ✗No insurance accepted — cash pay, HSA/FSA eligible
- ✗Intro discount applies only to the first order — ongoing rates are $212–$322/mo on 12-month plans, or $249–$379/mo month-to-month
Gala
Verified partnerBest for: compounded GLP-1/GIP combo on a yearly plan with free shipping
Gala (legal entity AI Coaching Inc., d/b/a Gala GLP-1) is a Delaware-incorporated telehealth platform selling compounded GLP-1/GIP (tirzepatide) on a yearly subscription, a lower-priced microdosing version of the same protocol, and brand-name Ozempic. It does not sell a compounded semaglutide product. The marketing site claims licensed providers in all 50 states with free shipping included. An oral Wegovy pill option is listed as 'coming soon.'
Score Breakdown
Pros
- ✓Compounded semaglutide and tirzepatide at $179/mo with all doses included on the yearly plan
- ✓Lower microdosing tirzepatide tier at $149/mo for a sub-therapeutic starting protocol
- ✓Brand-name Ozempic available alongside compounded options
- ✓Claims licensed providers in all 50 states with free shipping included
- ✓24/7 support, provider visit included, cancel anytime
- ✓LegitScript verified
Cons
- ✗$179/mo requires a yearly subscription — the standalone monthly price isn't published
- ✗Brand-name Ozempic at $1,299/mo is higher than peers (e.g., Found at $1,100/mo)
- ✗Pharmacy partners not named — only a "network of pharmacies" reference
- ✗Wegovy oral pill listed as "coming soon," not yet available
- ✗Per-state availability isn't listed; the all-50-states claim is gated behind intake
bmiMD
Verified partnerBest for: mainstream telehealth GLP-1 access
Medical weight loss clinic offering GLP-1 prescriptions through telehealth.
Score Breakdown
Pros
- ✓Both semaglutide and tirzepatide available
Cons
- ✗Cheapest advertised rates require a 12-month prepaid plan — month-to-month is $129 for semaglutide and $139 for sermorelin injection
How to choose where to get your weight loss shot
First, make sure it's a shot that works: only GLP-1 injections (semaglutide, tirzepatide) have trial evidence — B12, lipotropic (MIC), and HCG shots do not. Once you're comparing legitimate GLP-1 providers, these are the things that matter.
What to look for
- A GLP-1, not a vitamin shot. If a clinic sells B12, lipotropic, or HCG shots as a weight-loss treatment, walk away — none causes weight loss on its own. The shots that work are semaglutide and tirzepatide.
- Named, certified pharmacy. For compounded GLP-1 shots, a named 503A/503B pharmacy with LegitScript certification is the single most important trust signal.
- Honest, all-in pricing. Watch for a low first-month price that jumps at higher doses, or a membership stacked on top of the medication. Confirm the ongoing monthly total before you pay.
Red flags to avoid
- No named pharmacy or LegitScript listing. A legitimate compounded-GLP-1 provider names its 503A/503B pharmacy partner and carries LegitScript certification. If neither is disclosed, you can't verify what you're injecting.
- Async-only, no real clinician review. A prescriber should review your intake and be reachable for dose questions. Instant approval with no way to reach a clinician is a safety gap.
- Teaser pricing that hides the real cost. A low 'first month' price that jumps at higher doses, or a membership fee stacked on top of the medication, can double the true monthly total. Confirm the ongoing, all-in price before you pay.
- Weight-loss claims for B12, MIC, or HCG shots. Only GLP-1 injections have trial evidence for weight loss. A clinic selling B12, lipotropic, or HCG shots as a weight-loss treatment is a red flag.
Every provider ranked above is scored against these criteria across our six-dimension methodology, and prices are re-verified against each provider’s live site.
How we rank & what counts as “legit”
Every provider in this ranking is scored against our published six-factor rubric[1] — value, effectiveness, user experience, trust & safety, accessibility, and support.
Brand-name Wegovy, Zepbound, Ozempic, and Mounjaro are separately FDA-approved under their own NDA numbers[4][5]. Published Phase 3 efficacy for semaglutide 2.4 mg (~14.9% mean weight loss over 68 weeks) comes from the STEP 1 trial[6], and for tirzepatide (~20.9% at the 15 mg dose over 72 weeks) from SURMOUNT-1[7]; the SURMOUNT-5 head-to-head published in 2025 compared the two directly[8].
Insurance coverage for anti-obesity medications varies widely by state Medicaid program and commercial plan[9][10]. Compounded and brand-name GLP-1s are generally FSA/HSA eligible with a prescription under IRS Publication 502[11].
Frequently Asked Questions
Sources & methodology — as of August 2026
- 1.Weight Loss Rankings — GLP-1 Pricing Index 2026 (our independent dataset)— WeightLossRankings.org.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 5.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
- 8.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.
- 9.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 10.CMS — Medicaid prescription drug coverage policy (state-by-state)— Centers for Medicare & Medicaid Services.
- 11.IRS Publication 502 — Medical and Dental Expenses (HSA/FSA eligibility)— Internal Revenue Service.