Onyx Weight Loss Review
Semaglutide & tirzepatide GLP-1 weight-loss telehealth · Independently scored 6.2/10
Best for: NP-led GLP-1 telehealth in 8 states; sema $228/mo or tirz $280/mo, all-in
Price is where Onyx Weight Loss scores best in our breakdown.
Semaglutide
Tirzepatide
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
No insurance needed · Vetted by our editors
Onyx Weight Loss is a nurse-practitioner-led telehealth clinic based in Mooresville, NC, offering GLP-1 and GLP-1/GIP weight-loss medications alongside peptides and HRT across 8 states. Founded by Tasha Vangile FNP-C and Madalyn Vangile RN, plans start at $228/month for GLP-1 (semaglutide-type) and $280/month for GLP-1/GIP (tirzepatide-type), with medication and supplies shipped home via Strive Pharmacy partner. A $99/month GLP-1 microdosing option is also available for a gradual-titration start.
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Vetted alternatives to Onyx Weight Loss
Editorial score · methodology
Editorial score · methodology
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Best for: nationwide compounded GLP-1 availability including Puerto Rico
Editorial score · methodology
Onyx Weight Loss at a glance
- Type
- GLP-1 telehealth provider
- Medications
- Semaglutide, Tirzepatide
- Starting price
- $99/mo (Verbatim: '$99/MONTH' (GLP-1 Microdosing plan). Low-dose gradual-start option.)
- What's included
- Medication · Consult · Shipping
- Availability
- 8 states
- FDA status
- No FDA warning letter on record
How we scored Onyx Weight Loss
Each dimension is scored algorithmically from Onyx Weight Loss’s real pricing, drugs offered, verification status, and disclosed inclusions — using the same six-dimension framework we apply to every provider.
Value25%
7.5/10At $99/mo, Onyx Weight Loss runs about 41% below the $169 median for GLP-1 providers.
Effectiveness25%
6.5/10Onyx Weight Loss offers both semaglutide and tirzepatide — the two GLP-1 molecules with the strongest published weight-loss trial outcomes.
User Experience15%
5.8/10Online intake and platform experience — consult included in the price; 8 platform features disclosed.
Trust & Safety15%
6.4/10Core details confirmed by our editors; no FDA warning letters on file; dispenses through an accredited compounding pharmacy.
Accessibility10%
4.0/10Onyx Weight Loss operates in a limited 8-state footprint — check availability first.
Support10%
4.3/10Onyx Weight Loss provides standard clinician follow-up; no extended coaching or community program is disclosed.
Providers that don’t post pricing up front score lower on Value and carry a cost-transparency note in their review. Read the full methodology →
How we verified this Onyx Weight Loss review
Last checked August 2026- Confirmed current pricing across 3 dose/plan tiers
- Confirmed availability in 8 states
- Confirmed what the monthly price does and doesn't include
- Checked the FDA warning-letter database for enforcement actions
- Walked the public intake/checkout flow on the provider's site
Pricing, availability, and compliance facts come from the provider's own site and primary regulatory records — see the sources below. Editorial confidence in this data: medium.
What we checked
- Provider's own pricing page
- $99–$280/mo across 3 dose/plan tiers — checked August 2026
- FDA warning-letter register
- No letter on file for this provider
What to expect when you sign up with Onyx Weight Loss
We walked Onyx Weight Loss’s public signup flow in July 2026 to document the process — the steps, pricing transparency, and what’s required — before you commit. (We don’t create accounts, enter medical information, or check out; this is the observable funnel, not a prescribing outcome.)
- 1Book your consultation and select a service and appointment time.
- 2Complete the intake and consent form at least 48 hours before your appointment.
- 3Meet your personal provider and receive a customized plan.
- 4Start your plan with ongoing curated support.
- Offers GLP-1 and GLP-1/GIP agonist plans (semaglutide, tirzepatide).
- Pricing shown up front: 10-Week GLP-1 Flex Plan from $228/month; GLP-1/GIP Flex Plan from $280/month.
- Intake and consent must be completed at least 48 hours before the appointment (added friction).
- A support phone number is published but no email.
- Refund/cancellation and shipping details are not stated.
Onyx Weight Loss customer support
- Phone
- (704) 659-4633
GLP-1 medications Onyx Weight Loss offers
Tap any medication to read our plain-English guide — how it works, dosing, side effects, and what the trials found.
Peptides Onyx Weight Loss offers
Beyond GLP-1s, Onyx Weight Loss also offers these peptides — tap any for our evidence-based guide.
Pricing
Prices re-verified
Verbatim: 'Starting at $228/month' (GLP-1 Agonist plan). Includes medication and supplies shipped to home. Entry tier only; higher-dose pricing not disclosed.
Verbatim: 'Starting at $280/month' (GLP-1/GIP Agonist plan). Includes medication and supplies. Entry tier only; specific drug name inferred from GLP-1/GIP dual agonist designation.
Verbatim: '$99/MONTH' (GLP-1 Microdosing plan). Low-dose gradual-start option.
Ready to get started?
Plans and promotions change often — check Onyx Weight Loss's current pricing and active discounts before you decide.
What we like
- Competitive entry pricing: semaglutide from $228/mo and tirzepatide from $280/mo with medication + supplies included
- Nurse-practitioner-led care: founder Tasha Vangile FNP-C (20+ years) and Stephanie Robison APRN-CNP (27 years experience)
- Low-cost $99/mo GLP-1 microdosing option for patients who prefer a gradual titration start
- Strive Pharmacy partnership implies compounded 503A-quality supply chain from a known pharmacy
- Multi-modal clinic: GLP-1 + peptides + HRT + nutrition coaching available under one provider team
Watch-outs
- Only 8 states (NC, CO, ME, VT, VA, IA, NH, PA) — excludes the majority of the US
- No LegitScript certification; credentialing evidence limited to local 2025 Best of Iredell award
- Specific drug names (semaglutide/tirzepatide) never stated on website; compounded status inferred, not disclosed
- Labs not included or mentioned; no baseline bloodwork protocol published
- Pricing shown as 'Starting at' with no dose-escalation tier pricing disclosed publicly
Is Onyx Weight Loss worth it?
Onyx Weight Loss's whole pitch comes down to this: NP-led GLP-1 telehealth in 8 states; sema $228/mo or tirz $280/mo, all-in. It runs $99/month — toward the affordable end of the category, so cost isn't the reason to look elsewhere. It's a fairly plain, no-frills entry in the glp-1 providers category, without a lot of extra add-ons layered on top of the medication itself.
Worth knowing before you sign up: Onyx Weight Loss offers a microdosing option and is led by an advanced-practice clinician.
How much Onyx Weight Loss actually costs
Compounded semaglutide runs $228/month, compounded tirzepatide runs $280/month, and compounded semaglutide runs $99/month.
That puts Onyx Weight Loss below the roughly $169 median ongoing price across the GLP-1 providers we track — a real cost advantage.
bmiMD (about $99/month) is one of the closest alternatives to weigh Onyx Weight Loss against.
Medications: what Onyx Weight Loss prescribes
Onyx Weight Loss prescribes semaglutide (the active drug in Wegovy and Ozempic) and tirzepatide (the active drug in Zepbound and Mounjaro) — the two molecules with the strongest published weight-loss trial outcomes. The medication is compounded at a licensed pharmacy rather than sold as a brand pen, which is what keeps the price down. The trade-off is the one every compounded provider shares: compounded drugs aren't FDA-approved as finished products.
Who Onyx Weight Loss is best for — and who should skip it
A good fit if you…
- are focused on the lowest ongoing monthly cost — $99/month is below the roughly $169 median we track across the category.
Look elsewhere if you…
- specifically want an FDA-approved brand-name pen instead of a compounded formulation — that's not what this provider fills.
- need to bill insurance, since like most of this market it's cash-pay with no claims filed on your behalf.
Trust, safety, and medical oversight
Onyx Weight Loss is available in 8 states, and dispenses through an accredited compounding pharmacy, and we found no FDA warning letter on file for it. As with any compounded program, the most important step you can take is confirming which licensed pharmacy fills your prescription and what's in the formulation — we explain how in our scoring methodology.
Bottom line
Onyx Weight Loss earns its place on the shortlist mainly on price: at $99/month it's one of the more affordable ways to stay on a GLP-1, without obvious corners cut on access or oversight.
The Bottom Line
Price is where Onyx Weight Loss scores best in our breakdown.
Ready to start with Onyx Weight Loss?
Starting at $99/month. See current pricing and start your free consultation.
Onyx Weight Loss might not be your best fit if…
We rank editorially, so here’s where a different provider we track may serve you better.
- If you want brand-name Ozempic, Wegovy, Mounjaro or Zepbound, consider GobyMeds.
- If the lowest possible monthly price is your top priority, consider Collective (from $59/mo).
- If you want built-in coaching and behavior-change support, consider TMates.
Frequently Asked Questions
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Sources
The primary regulatory filings and peer-reviewed studies cited throughout this Onyx Weight Loss review:
Sources & methodology — as of October 2026
- 1.Weight Loss Rankings — GLP-1 Pricing Index 2026 (our independent dataset)— WeightLossRankings.org.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
- 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 9.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
- 10.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 11.FDA — Mounjaro (tirzepatide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 12.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.
See Onyx Weight Loss's current pricing
Plans start at $99/month. Start your free consultation to check eligibility and today's price.