Onyx Weight Loss Review
Best for: NP-led GLP-1 telehealth across 8 states; sema from $228/mo or tirz from $280/mo, med+ship incl.
Onyx Weight Loss is a nurse-practitioner-led telehealth clinic based in Mooresville, NC, offering GLP-1 and GLP-1/GIP weight-loss medications alongside peptides and HRT across 8 states. Founded by Tasha Vangile FNP-C and Madalyn Vangile RN, plans start at $228/month for GLP-1 (semaglutide-type) and $280/month for GLP-1/GIP (tirzepatide-type), with medication and supplies shipped home via Strive Pharmacy partner. A $99/month GLP-1 microdosing option is also available for a gradual-titration start.
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
No insurance needed · Vetted by our editors
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The Bottom Line
Onyx Weight Loss is a solid telehealth option with balanced features and pricing.
Onyx Weight Loss at a glance
- Type
- GLP-1 telehealth provider
- Medications
- Semaglutide, Tirzepatide
- Starting price
- $99/mo (Verbatim: 'Starting at $228/month' (GLP-1 Agonist plan). Includes medication and supplies shipped to home. Entry tier only; higher-dose pricing not disclosed.)
- What's included
- Medication · Consult · Shipping
- Availability
- 8 states
- FDA status
- No FDA warning letter on record
How we scored Onyx Weight Loss
Each dimension is scored algorithmically from Onyx Weight Loss’s real pricing, drugs offered, verification status, and disclosed inclusions — using the same six-dimension framework we apply to every provider.
Value25%
7.4/10At $99/mo, Onyx Weight Loss runs about 42% below the $170 median for GLP-1 providers.
Effectiveness25%
6.4/10Onyx Weight Loss offers both semaglutide and tirzepatide — the two GLP-1 molecules with the strongest published weight-loss trial outcomes.
User Experience15%
5.7/10Online intake and platform experience — consult included in the price; 8 platform features disclosed.
Trust & Safety15%
6.3/10Core details confirmed by our editors; no FDA warning letters on file; dispenses through an accredited compounding pharmacy (last checked 2026-07-04).
Accessibility10%
3.9/10Onyx Weight Loss operates in a limited 8-state footprint — check availability first.
Support10%
4.2/10Onyx Weight Loss provides standard clinician follow-up; no extended coaching or community program is disclosed.
How we verified this Onyx Weight Loss review
Last checked 2026-07-04- Confirmed current pricing across 3 dose/plan tiers
- Confirmed availability in 8 states
- Confirmed what the monthly price does and doesn't include
- Checked the FDA warning-letter database for enforcement actions
- Walked the public intake/checkout flow on the provider's site
Pricing, availability, and compliance facts come from the provider's own site and primary regulatory records — see the sources below. Editorial confidence in this data: medium.
GLP-1 medications Onyx Weight Loss offers
Tap any medication to read our plain-English guide — how it works, dosing, side effects, and what the trials found.
Pricing
Verbatim: 'Starting at $228/month' (GLP-1 Agonist plan). Includes medication and supplies shipped to home. Entry tier only; higher-dose pricing not disclosed.
Verbatim: 'Starting at $280/month' (GLP-1/GIP Agonist plan). Includes medication and supplies. Entry tier only; specific drug name inferred from GLP-1/GIP dual agonist designation.
Verbatim: '$99/MONTH' (GLP-1 Microdosing plan). Low-dose gradual-start option.
Ready to get started?
Plans and promotions change often — check Onyx Weight Loss's current pricing and active discounts before you decide.
What we like
- Competitive entry pricing: semaglutide from $228/mo and tirzepatide from $280/mo with medication + supplies included
- Nurse-practitioner-led care: founder Tasha Vangile FNP-C (20+ years) and Stephanie Robison APRN-CNP (27 years experience)
- Low-cost $99/mo GLP-1 microdosing option for patients who prefer a gradual titration start
- Strive Pharmacy partnership implies compounded 503A-quality supply chain from a known pharmacy
- Multi-modal clinic: GLP-1 + peptides + HRT + nutrition coaching available under one provider team
Watch-outs
- Only 8 states (NC, CO, ME, VT, VA, IA, NH, PA) — excludes the majority of the US
- No LegitScript certification; credentialing evidence limited to local 2025 Best of Iredell award
- Specific drug names (semaglutide/tirzepatide) never stated on website; compounded status inferred, not disclosed
- Labs not included or mentioned; no baseline bloodwork protocol published
- Pricing shown as 'Starting at' with no dose-escalation tier pricing disclosed publicly
Is Onyx Weight Loss worth it? Our verdict
Onyx Weight Loss positions itself around one thing: NP-led GLP-1 telehealth across 8 states; sema from $228/mo or tirz from $280/mo, med+ship incl.. It runs $99/month — toward the affordable end of the market.
What gives Onyx Weight Loss its own flavor: GLP-1 Microdosing, NP-Led Care, and Strive Pharmacy Partner.
How much Onyx Weight Loss actually costs
- Compounded semaglutide — $228/month
- Compounded tirzepatide — $280/month
- Compounded semaglutide — $99/month
That puts Onyx Weight Loss below the roughly $170 median ongoing price across the GLP-1 providers we track — a real cost advantage.
For a direct comparison, Telos Rx runs semaglutide and tirzepatide from $49/month — worth pricing against Onyx Weight Loss before you commit.
Medications: what Onyx Weight Loss prescribes
Onyx Weight Loss prescribes semaglutide (the active drug in Wegovy and Ozempic) and tirzepatide (the active drug in Zepbound and Mounjaro) — the two molecules with the strongest published weight-loss trial outcomes. The medication is compounded at a licensed pharmacy rather than sold as a brand pen, which is what keeps the price down. The trade-off is the one every compounded provider shares: compounded drugs aren't FDA-approved as finished products.
Who Onyx Weight Loss is best for — and who should skip it
A good fit if you…
- are focused on the lowest ongoing monthly cost.
Look elsewhere if you…
- specifically want an FDA-approved brand-name pen.
- need to bill insurance — like most of this market, it's cash-pay.
Trust, safety, and medical oversight
Onyx Weight Loss is available in 8 states, and dispenses through an accredited compounding pharmacy. We found no FDA warning letters on file for the provider. As with any compounded program, the most important step you can take is confirming which licensed pharmacy fills your prescription and what's in the formulation — we explain how in our scoring methodology.
Bottom line
Onyx Weight Loss earns its place on the shortlist mainly on price: at $99/month it's one of the more affordable ways to stay on a GLP-1, without obvious corners cut on access or oversight.
Ready to start with Onyx Weight Loss?
Starting at $99/month. See current pricing and start your free consultation.
Alternatives to Onyx Weight Loss
Enhance MD
Best for: lab-monitored compounded GLP-1 with mandatory video visit
Editorial score · methodology
Editorial score · methodology
Editorial score · methodology
Frequently Asked Questions
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Sources
The primary regulatory filings and peer-reviewed studies cited throughout this Onyx Weight Loss review:
Sources & methodology — as of July 2026
- 1.Weight Loss Rankings — GLP-1 Pricing Index 2026 (our independent dataset)— WeightLossRankings.org.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
- 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 9.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
- 10.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 11.FDA — Mounjaro (tirzepatide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 12.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.
Ready to start with Onyx Weight Loss?
Starting at $99/month. See current pricing and start your free consultation.