Enhance MD vs RxSpan MD
In our scoring, Enhance MD edges ahead overall (8.2 vs 8.1 out of 10), and Enhance MD costs less for compounded semaglutide (about $444 a year less).
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Key differences
- Price
- Enhance MD $212/mo vs RxSpan MD $249/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $444 a year less with Enhance MD)
- Coverage
- Enhance MD 39 states; RxSpan MD 50 states (only RxSpan MD: Alabama, Arkansas, Georgia and 8 more)
- Included
- Enhance MD: medication, clinician visits, labs; RxSpan MD: medication, clinician visits, shipping, coaching
Enhance MD
Affiliate partnerBest for lab-monitored compounded GLP-1 with mandatory video visit
semaglutide
$212
$112 first month
Our score 8.2/10
RxSpan MD
Affiliate partnerBest for physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
semaglutide
$249
Our score 8.1/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Enhance MD
RxSpan MD
Price
Semaglutide / month
Better on this row: $212/mo
$112 first month
$249/mo
Semaglutide / year (modeled)
Better on this row: $2,544
$2,988
Tirzepatide / month
Better on this row: $169/mo
$329/mo
Tirzepatide / year (modeled)
Better on this row: $2,028
$3,948
Oral semaglutide / month
Not listed
$249/mo
Oral tirzepatide / month
Not listed
$349/mo
Brand Wegovy / Ozempic / month
Not listed
$1,299/mo
Brand Zepbound / Mounjaro / month
Not listed
$1,069/mo
Coverage
State availability
39 states
50 states
Oral option listed
Not listed
Yes
Brand-name access listed
Not listed
Wegovy / Ozempic, Zepbound / Mounjaro
Included in the price
Medication, clinician visits, labs
Medication, clinician visits, shipping, coaching
Terms & safety
Price shown
Before intake
Before intake
Lab work
Required
Not disclosed
Video visit
Required
Not disclosed
Cancel anytime
Yes
Yes
Minimum commitment
None
None
Early-cancellation fee
Not disclosed
None
FDA warning letters
None on record
None on record
Provider facts checked
August 2026
August 2026
Show where they differ by stateHide state lists
Only RxSpan MD (11 states)
- Alabama
- Arkansas
- Georgia
- Hawaii
- Louisiana
- Mississippi
- Missouri
- North Dakota
- South Carolina
- Tennessee
- West Virginia
Every dose and plan: Enhance MD · RxSpan MD
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Enhance MD if…
- About $444 a year less than RxSpan MD for compounded semaglutide at standing prices
- Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
What to weigh up
- Not available in 11 states that RxSpan MD serves
- Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
Choose RxSpan MD if…
- Lists oral compounded semaglutide, oral compounded tirzepatide and brand-name Wegovy / Ozempic, which Enhance MD doesn't price
- Serves 11 states that Enhance MD doesn't
- Physician-led — founded by Dr. John Diaz, a board-certified plastic surgeon with 20+ years' experience
What to weigh up
- About $444 a year more than Enhance MD for compounded semaglutide
- Compounded pricing ($249 semaglutide / $329 tirzepatide) sits mid-to-high versus the cheapest telehealth options
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Enhance MD
8.2/10
RxSpan MD
8.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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SkinnyRx
Compounded semaglutide or tirzepatide with the consult and free overnight shipping in one price
Read full review →From $149.25/mo
Get started →Collective
The lowest flat medication price if you can absorb an annual membership fee
Read full review →From $59/mo + membership
Get started →From $219/mo
Get started →Enhance MD vs RxSpan MD: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.