RxSpan MD vs Vytora Health
Our featured pick: RxSpan MD (affiliate partner). In our scoring, RxSpan MD scores 8.1 and Vytora Health 8.4 out of 10, and Vytora Health costs less for compounded semaglutide (about $840 a year less).
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
Key differences
- Price
- Vytora Health $179/mo vs RxSpan MD $249/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $840 a year less with Vytora Health)
- Coverage
- RxSpan MD 50 states; Vytora Health 50 states + DC (only Vytora Health: District of Columbia)
- Included
- RxSpan MD: medication, clinician visits, shipping, coaching; Vytora Health: medication, clinician visits, shipping
RxSpan MD
Affiliate partnerBest for physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
semaglutide
$249
Our score 8.1/10
Vytora Health
Best for compounded or brand-name GLP-1 with named pharmacy partners, 50 states
semaglutide
$179
Our score 8.4/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
RxSpan MD
Vytora Health
Price
Semaglutide / month
$249/mo
Better on this row: $179/mo
Semaglutide / year (modeled)
$2,988
Better on this row: $2,148
Tirzepatide / month
$329/mo
Better on this row: $249/mo
Tirzepatide / year (modeled)
$3,948
Better on this row: $2,988
Brand Zepbound / Mounjaro / month
Better on this row: $1,069/mo
$1,399/mo
Brand Zepbound / Mounjaro / year (modeled)
Better on this row: $12,828
$16,788
Oral semaglutide / month
$249/mo
Not listed
Oral tirzepatide / month
$349/mo
Not listed
Brand Wegovy / Ozempic / month
$1,299/mo
Not listed
Coverage
State availability
50 states
50 states + DC
Oral option listed
Yes
Not listed
Brand-name access listed
Zepbound / Mounjaro, Wegovy / Ozempic
Zepbound / Mounjaro
Included in the price
Medication, clinician visits, shipping, coaching
Medication, clinician visits, shipping
Terms & safety
Price shown
Before intake
Before intake
Cancel anytime
Yes
Yes
Minimum commitment
None
None on monthly plans; 3-month plans are billed every 3 months
Refunds
Not disclosed
'All sales are final' for prescription products; refund requests 'reviewed on a case-by-case basis'
Early-cancellation fee
None
Not disclosed
FDA warning letters
None on record
None on record
Provider facts checked
August 2026
October 2026
Show where they differ by stateHide state lists
Only Vytora Health (DC)
- District of Columbia
Every dose and plan: RxSpan MD · Vytora Health
Get alerted when GLP-1 prices drop
Join the GLP-1 price-watch list — we re-verify 500+ providers' prices on their own sites and email you when tracked prices move.
Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose RxSpan MD if…
- Lists oral compounded semaglutide, oral compounded tirzepatide and brand-name Wegovy / Ozempic, which Vytora Health doesn't price
- Physician-led: founded by Dr. John Diaz, a board-certified plastic surgeon with 20+ years' experience
- Names its 503A pharmacy partners (Belmar, Strive, Epiq Scripts, Casa Pharma) and medical group
What to weigh up
- About $840 a year more than Vytora Health for compounded semaglutide
- Not available in District of Columbia
Choose Vytora Health if…
- About $840 a year less than RxSpan MD for compounded semaglutide at standing prices
- Serves District of Columbia, where RxSpan MD doesn't
- Both compounded and brand-name options on one platform
What to weigh up
- Brand-name Mounjaro and Zepbound at $1,399/mo are priced at retail; manufacturer self-pay programs are often cheaper
- Compounded tirzepatide at $249/mo month-to-month is mid-market
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
RxSpan MD
8.1/10
Vytora Health
8.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online.
No insurance needed · vetted by our editors
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
Ro
FDA-approved brand GLP-1s, including the Wegovy pill and Foundayo, with insurance help
Read full review →From $149/mo (+ required membership)
Get started →Collective
The lowest flat medication price if you can absorb an annual membership fee
Read full review →From $59/mo (+ required membership)
Get started →CoreAge Rx
Lowest-price compounded semaglutide and tirzepatide with one flat price at every dose
Read full review →From $79/mo (“starting at” price)
Get started →RxSpan MD vs Vytora Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Related comparisons
Continue exploring RxSpan MD and Vytora Health head-to-heads in the same category.
- RxSpan MD vs Amazon One Medical
- RxSpan MD vs CoreAge Rx
- RxSpan MD vs Collective
- Vytora Health vs Amazon One Medical
- Vytora Health vs CoreAge Rx
- Vytora Health vs Collective
Or see the full category ranking, or alternatives to RxSpan MD and Vytora Health.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.