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RxSpan MD vs Vytora Health

An in-depth comparison of two leading GLP-1 Providers

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7.4

RxSpan MD

Best for shoppers wanting physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
★★★★☆3.7

Starting at $249/mo

CompoundedSemaglutideTirzepatideBrand-name available
Visit RxSpan MD →
8.7

Vytora Health

Best for compounded or brand-name GLP-1 with named pharmacy partners, 50 states
★★★★☆4.4

Starting at $150/mo

CompoundedBrandZepboundMounjaro
Visit Vytora Health →

Side-by-Side Comparison

FeatureRxSpan MDVytora Health
Overall Score7.4/10✓8.7/10
Starting Price$249/mo✓$150/mo
Editorial Rating3.7 ★ /5✓4.4 ★ /5
Features7 features✓8 features
States Available50✓51
Compounded✓ Yes✓ Yes
Brand Name✓ Yes✓ Yes
FSA/HSA Accepted——
FDA WarningsNoneNone

Pros & Cons

RxSpan MD

What we like

  • Physician-led — founded by Dr. John Diaz, a board-certified plastic surgeon with 20+ years' experience
  • Compounded semaglutide and tirzepatide from $249/mo (injection or oral capsules), plus brand-name Wegovy, Zepbound and Ozempic
  • Names its 503A pharmacy partners (Belmar, Strive, Epiq Scripts, Casa Pharma) and medical group
  • LegitScript-certified (#50405601); free expedited shipping and unlimited 24/7 support included
  • Available in all 50 states via a 2-minute assessment

Watch-outs

  • Compounded pricing ($249 semaglutide / $329 tirzepatide) sits mid-to-high versus the cheapest telehealth options
  • Brand-name GLP-1 is priced steeply (Wegovy $1,349, Ozempic $1,299, Zepbound $1,069)
  • Multi-vertical practice (also hair, sexual health, longevity), not weight-loss-only
  • Legal entity name isn't published on the site

Vytora Health

What we like

  • All 50 states plus DC, with per-state video-vs-audio compliance disclosed
  • Both compounded and brand-name options on one platform — uncommon
  • LegitScript Approved and HIPAA compliant
  • Pharmacy partners named publicly: Vials Pharmacy (TX) and Greenwich Biosciences
  • Operating entity disclosed: Wasef Health, PC (Pinellas Park, FL)
  • Competitive monthly pricing ($180 sema / $249 tirz) plus a 3-month bundle saving 17%
  • Brand-name Mounjaro and Zepbound available at $1,399/mo for FDA-approved options

Watch-outs

  • Brand-name Mounjaro/Zepbound at $1,399/mo is near retail — insured patients may do better via LillyDirect Self Pay ($449-$699/mo)
  • Compounded tirzepatide at $249/mo is mid-market, above the $149-199 floor
  • Dose tiers aren't broken out — 'all doses included' means low-dose patients pay the same as high-dose
  • Initial consultation cost not shown on the public pricing page
  • Limited per-prescriber state licensure detail

Our Verdict

Winner: Vytora HealthScore: 8.7/10

Vytora Health edges out RxSpan MD with a higher overall score of 8.7/10 and is particularly strong for compounded or brand-name GLP-1 with named pharmacy partners, 50 states. RxSpan MD remains a solid alternative, especially if you're looking for shoppers wanting physician-led, pharmacy-transparent compounded GLP-1 with brand-name options.

Get Started with RxSpan MD →Get Started with Vytora Health →

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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.