Direct Meds vs RxSpan MD
In our scoring, RxSpan MD edges ahead overall (8.1 vs 6.4 out of 10), and RxSpan MD costs less for compounded semaglutide (about $576 a year less).
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Key differences
- Price
- RxSpan MD $249/mo vs Direct Meds $297/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $576 a year less with RxSpan MD)
- Coverage
- RxSpan MD 50 states (Direct Meds doesn't publish a state list)
- Included
- Direct Meds: medication, clinician visits, shipping; RxSpan MD: medication, clinician visits, shipping, coaching
- Safety
- FDA warning letters on record: Direct Meds 1, RxSpan MD none
Direct Meds
Affiliate partnerLegitScript Certified
semaglutide
$297
Our score 6.4/10
RxSpan MD
Affiliate partnerBest for physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
semaglutide
$249
Our score 8.1/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Direct Meds
RxSpan MD
Price
Semaglutide / month
$297/mo
Better on this row: $249/mo
Semaglutide / year (modeled)
$3,564
Better on this row: $2,988
Tirzepatide / month
$399/mo
Better on this row: $329/mo
Tirzepatide / year (modeled)
$4,788
Better on this row: $3,948
Oral semaglutide / month
$249/mo
$249/mo
Oral semaglutide / year (modeled)
$2,988
$2,988
Oral tirzepatide / month
Better on this row: $299/mo
$349/mo
Oral tirzepatide / year (modeled)
Better on this row: $3,588
$4,188
Brand Wegovy / Ozempic / month
Not listed
$1,299/mo
Brand Zepbound / Mounjaro / month
Not listed
$1,069/mo
Coverage
State availability
List not published
50 states
Oral option listed
Yes
Yes
Brand-name access listed
Not listed
Wegovy / Ozempic, Zepbound / Mounjaro
Included in the price
Medication, clinician visits, shipping
Medication, clinician visits, shipping, coaching
Terms & safety
Price shown
Before intake
Before intake
Cancel anytime
No
Better on this row: Yes
Minimum commitment
3-month prepay
None
Early-cancellation fee
Yes
Better on this row: None
FDA warning letters
1 warning letter
Better on this row: None on record
Provider facts checked
August 2026
August 2026
Every dose and plan: Direct Meds · RxSpan MD
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Direct Meds if…
- All-inclusive pricing covers medication, consultations, supplies, and 1–2 day temperature-controlled shipping
- LegitScript Certified
- Named 503A pharmacy partners: CraftedRx (MO) and ChemistryRx (PA)
What to weigh up
- 1 FDA warning letter on record
- About $576 a year more than RxSpan MD for compounded semaglutide
Choose RxSpan MD if…
- About $576 a year less than Direct Meds for compounded semaglutide at standing prices
- Lists brand-name Wegovy / Ozempic and brand-name Zepbound / Mounjaro, which Direct Meds doesn't price
- Publishes its full state list (50 states)
What to weigh up
- Compounded pricing ($249 semaglutide / $329 tirzepatide) sits mid-to-high versus the cheapest telehealth options
- Brand-name GLP-1 is priced steeply (Wegovy $1,349, Ozempic $1,299, Zepbound $1,069)
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Direct Meds
6.4/10
RxSpan MD
8.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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From $299/mo
Get started →SkinnyRx
Compounded semaglutide or tirzepatide with the consult and free overnight shipping in one price
Read full review →From $149.25/mo
Get started →Collective
The lowest flat medication price if you can absorb an annual membership fee
Read full review →From $59/mo + membership
Get started →Direct Meds vs RxSpan MD: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.