Amazon One Medical vs RxSpan MD
An in-depth comparison of two leading GLP-1 Providers
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Amazon One Medical
Best for: the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings
Visit Amazon One Medical →
RxSpan MD
Best for: shoppers wanting physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
Visit RxSpan MD →Amazon One Medical and RxSpan MD are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Amazon One Medical starts lower at $149/mo versus $249/mo, and RxSpan MD is the option we'd start with for most patients. Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Amazon One Medical
RxSpan MD
Plan ladder: Monthly $249/mo, 3-mo $219/mo, 6-mo $199/mo, 12-mo $194/mo. Card labeled '(For the first month)'; plan picker shows flat recurring rates (Total if prescribed $657 on 3-mo).
Plan ladder: Monthly $249/mo, 3-mo $219/mo, 6-mo $199/mo, 12-mo $179/mo.
Plan ladder: Monthly $329/mo, 3-mo $309/mo, 6-mo $289/mo, 12-mo $269/mo (Total if prescribed $927 on 3-mo).
Plan ladder: Monthly $349/mo, 3-mo $299/mo, 6-mo $289/mo, 12-mo $269/mo (Total if prescribed $897 on 3-mo).
Monthly plan only ($1,069/mo).
Monthly plan only ($1,299/mo).
Monthly plan only ($1,349/mo).
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What’s included
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
RxSpan MD
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Amazon One Medical
8.5/10
RxSpan MD
8.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Amazon One Medical | RxSpan MD |
|---|---|---|
| Starting Price | ✓$149/mo | $249/mo |
| Features | 6 features | ✓7 features |
| States Available | 50 | 50 |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →About RxSpan MD
RxSpan MD is a physician-led telehealth practice founded by Dr. John Diaz, a board-certified plastic surgeon, offering compounded GLP-1 weight loss — semaglutide and tirzepatide from $249/mo, as injections or oral capsules — plus brand-name Wegovy, Zepbound and Ozempic. It's unusually transparent: it names its 503A pharmacy partners (Belmar, Strive, Epiq Scripts, Casa Pharma) and medical group, ships free, and includes unlimited 24/7 support. Available in all 50 states.
Read our full RxSpan MD review →Pros & Cons
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
RxSpan MD
What we like
- Physician-led — founded by Dr. John Diaz, a board-certified plastic surgeon with 20+ years' experience
- Compounded semaglutide and tirzepatide from $249/mo (injection or oral capsules), plus brand-name Wegovy, Zepbound and Ozempic
- Names its 503A pharmacy partners (Belmar, Strive, Epiq Scripts, Casa Pharma) and medical group
- LegitScript-certified (#50405601); free expedited shipping and unlimited 24/7 support included
- Available in all 50 states via a 2-minute assessment
Watch-outs
- Compounded pricing ($249 semaglutide / $329 tirzepatide) sits mid-to-high versus the cheapest telehealth options
- Brand-name GLP-1 is priced steeply (Wegovy $1,349, Ozempic $1,299, Zepbound $1,069)
- Multi-vertical practice (also hair, sexual health, longevity), not weight-loss-only
- Legal entity name isn't published on the site
Our Verdict
RxSpan MD is our recommended choice here, particularly for shoppers wanting physician-led, pharmacy-transparent compounded GLP-1 with brand-name options. Amazon One Medical is a solid alternative, especially if you want the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings — compare the six-dimension breakdown and pricing below to weigh them for your situation.
Choose Amazon One Medical if…
You want the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings and a starting price around $149/mo.
Choose RxSpan MD if…
You want shoppers wanting physician-led, pharmacy-transparent compounded GLP-1 with brand-name options and a starting price around $249/mo.
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TMates
Nationwide compounded GLP-1 availability including Puerto Rico
From $249/mo
Get started →Found
Mainstream telehealth GLP-1 access
From $99/mo
Get started →Breeze Meds
Compounded GLP-1 access with named prescribers and 4-pharmacy network
From $199/mo
Get started →Amazon One Medical vs RxSpan MD: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.