HumeCare+ vs RxSpan MD
In our scoring, RxSpan MD edges ahead overall (8.1 vs 7.2 out of 10), and HumeCare+ costs less for compounded semaglutide (about $600 a year less).
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Key differences
- Price
- HumeCare+ $199/mo vs RxSpan MD $249/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $600 a year less with HumeCare+)
- Coverage
- HumeCare+ 46 states + DC; RxSpan MD 50 states (only HumeCare+: District of Columbia · only RxSpan MD: Alabama, Arkansas, Louisiana and 1 more)
- Included
- HumeCare+: medication, clinician visits; RxSpan MD: medication, clinician visits, shipping, coaching
HumeCare+
Affiliate partnerBest for GLP-1 weight loss with real-time body-composition tracking to protect muscle
semaglutide
$199
Our score 7.2/10
RxSpan MD
Affiliate partnerBest for physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
semaglutide
$249
Our score 8.1/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
HumeCare+
RxSpan MD
Price
Semaglutide / month
Better on this row: $199/mo
$249/mo
Semaglutide / year (modeled)
Better on this row: $2,388
$2,988
Tirzepatide / month
Better on this row: $299/mo
$329/mo
Tirzepatide / year (modeled)
Better on this row: $3,588
$3,948
Oral semaglutide / month
Better on this row: $199/mo
$249/mo
Oral semaglutide / year (modeled)
Better on this row: $2,388
$2,988
Oral tirzepatide / month
Not listed
$349/mo
Brand Wegovy / Ozempic / month
Not listed
$1,299/mo
Brand Zepbound / Mounjaro / month
Not listed
$1,069/mo
Coverage
State availability
46 states + DC
50 states
Oral option listed
Yes
Yes
Brand-name access listed
Not listed
Wegovy / Ozempic, Zepbound / Mounjaro
Included in the price
Medication, clinician visits
Medication, clinician visits, shipping, coaching
Terms & safety
Price shown
Plan quoted after intake; a price is published
Before intake
Cancel anytime
Yes
Yes
Minimum commitment
None
None
Refunds
Terms: if the physician finds you ineligible the plan is refunded automatically and the Hume Pod must be returned. Otherwise there are no pro-rated refunds, and cancellation must be at least 48 hours before the renewal date. A clinical consultation fee assessed at enrollment and at each refill is carved out as non-refundable; its amount is not published.
Not disclosed
Early-cancellation fee
None
None
FDA warning letters
None on record
None on record
Provider facts checked
August 2026
August 2026
Show where they differ by stateHide state lists
Only HumeCare+ (DC)
- District of Columbia
Only RxSpan MD (4 states)
- Alabama
- Arkansas
- Louisiana
- Mississippi
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose HumeCare+ if…
- About $600 a year less than RxSpan MD for compounded semaglutide at standing prices
- Serves District of Columbia, where RxSpan MD doesn't
- Pairs compounded semaglutide with continuous body-composition tracking (lose fat, preserve muscle)
What to weigh up
- Not available in 4 states that RxSpan MD serves
- No price appears on the marketing site; you must finish the intake quiz and give your name before one is quoted
Choose RxSpan MD if…
- Lists oral compounded tirzepatide, brand-name Wegovy / Ozempic and brand-name Zepbound / Mounjaro, which HumeCare+ doesn't price
- Serves 4 states that HumeCare+ doesn't
- Physician-led — founded by Dr. John Diaz, a board-certified plastic surgeon with 20+ years' experience
What to weigh up
- About $600 a year more than HumeCare+ for compounded semaglutide
- Not available in District of Columbia
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
HumeCare+
7.2/10
RxSpan MD
8.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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SkinnyRx
Compounded semaglutide or tirzepatide with the consult and free overnight shipping in one price
Read full review →From $149.25/mo
Get started →Collective
The lowest flat medication price if you can absorb an annual membership fee
Read full review →From $59/mo + membership
Get started →From $219/mo
Get started →HumeCare+ vs RxSpan MD: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.