RxSpan MD vs ShedRx
In our scoring, RxSpan MD edges ahead overall (8.1 vs 8.0 out of 10), and ShedRx costs less for compounded semaglutide (about $1,200 a year less).
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Key differences
- Price
- ShedRx $149/mo vs RxSpan MD $249/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $1,200 a year less with ShedRx)
- Coverage
- RxSpan MD 50 states (ShedRx doesn't publish a state list)
- Included
- RxSpan MD: medication, clinician visits, shipping, coaching; ShedRx: medication, clinician visits, coaching
RxSpan MD
Affiliate partnerBest for physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
semaglutide
$249
Our score 8.1/10
ShedRx
Affiliate partnerBest for compounded GLP-1 as an injection, drops or lozenges, with lower rates on 6- and 12-month plans
semaglutide
$149
Our score 8.0/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
RxSpan MD
ShedRx
Price
Semaglutide / month
$249/mo
Better on this row: $149/mo
Semaglutide / year (modeled)
$2,988
Better on this row: $1,788
Tirzepatide / month
$329/mo
Better on this row: $199/mo
Tirzepatide / year (modeled)
$3,948
Better on this row: $2,388
Oral semaglutide / month
$249/mo
Better on this row: $199/mo
Oral semaglutide / year (modeled)
$2,988
Better on this row: $2,388
Semaglutide (pill or injection) / month
Not listed
$149/mo
+ separate membership
Oral tirzepatide / month
$349/mo
Not listed
Brand Wegovy / Ozempic / month
$1,299/mo
Not listed
Brand Zepbound / Mounjaro / month
$1,069/mo
Not listed
Brand Foundayo / month
Not listed
$149/mo
+ separate membership
Separate membership required
Not stated
Yes — not in the listed price
Coverage
State availability
50 states
List not published
Oral option listed
Yes
Yes
Brand-name access listed
Wegovy / Ozempic, Zepbound / Mounjaro
Foundayo
Included in the price
Medication, clinician visits, shipping, coaching
Medication, clinician visits, coaching
Terms & safety
Price shown
Before intake
Plan quoted after intake; a price is published
Video visit
Not disclosed
Not required
Cancel anytime
Yes
Not disclosed
Minimum commitment
None
None
Refunds
Not disclosed
120-day money-back guarantee
Early-cancellation fee
None
Not disclosed
FDA warning letters
None on record
None on record
Provider facts checked
August 2026
August 2026
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose RxSpan MD if…
- Lists oral compounded tirzepatide, brand-name Wegovy / Ozempic and brand-name Zepbound / Mounjaro, which ShedRx doesn't price
- Publishes its full state list (50 states)
- Physician-led — founded by Dr. John Diaz, a board-certified plastic surgeon with 20+ years' experience
What to weigh up
- About $1,200 a year more than ShedRx for compounded semaglutide
- Compounded pricing ($249 semaglutide / $329 tirzepatide) sits mid-to-high versus the cheapest telehealth options
Choose ShedRx if…
- About $1,200 a year less than RxSpan MD for compounded semaglutide at standing prices
- Lists compounded semaglutide (pill or injection) and brand-name Foundayo, which RxSpan MD doesn't price
- Multiple administration formats
What to weigh up
- No published state list; confirm yours at signup
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
RxSpan MD
8.1/10
ShedRx
8.0/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Ready to start? Vetted GLP-1 providers
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GobyMeds
No-membership, no-auto-renew compounded GLP-1 orders, from about $99/mo on a 3-month bundle
Read full review →From $169/mo
Get started →Ivim Health
Compounded GLP-1 with weekly provider check-ins and health coaches, under a required monthly membership
Read full review →From $65/mo + membership
Get started →From $247/mo
Get started →RxSpan MD vs ShedRx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.