PlexusDx vs RxSpan MD
In our scoring, RxSpan MD edges ahead overall (8.1 vs 7.0 out of 10).
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Key differences
- Price
- PlexusDx $129/mo no prepay listed; RxSpan MD $249/mo no prepay listed (compounded semaglutide · not like-for-like, so neither is marked cheaper)
- Coverage
- Both serve the same 50 states
- Included
- PlexusDx: medication, clinician visits; RxSpan MD: medication, clinician visits, shipping, coaching
PlexusDx
Affiliate partnerBest for nationwide compounded GLP-1 with optional genetic-test personalization
semaglutide
$129
microdose plan
Our score 7.0/10
RxSpan MD
Affiliate partnerBest for physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
semaglutide
$249
Our score 8.1/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
PlexusDx
RxSpan MD
Price
Semaglutide / month
$129/mo
microdose plan
$249/mo
Semaglutide / year (modeled)
$1,548
$2,988
Tirzepatide / month
$249/mo
starting dose
$329/mo
Tirzepatide / year (modeled)
$2,988
$3,948
Oral semaglutide / month
Not listed
$249/mo
Oral tirzepatide / month
Not listed
$349/mo
Brand Wegovy / Ozempic / month
Not listed
$1,299/mo
Brand Zepbound / Mounjaro / month
Not listed
$1,069/mo
Coverage
State availability
50 states
50 states
Oral option listed
Not listed
Yes
Brand-name access listed
Not listed
Wegovy / Ozempic, Zepbound / Mounjaro
Included in the price
Medication, clinician visits
Medication, clinician visits, shipping, coaching
Terms & safety
Price shown
Before intake
Before intake
Cancel anytime
Not disclosed
Yes
Minimum commitment
Not disclosed
None
Early-cancellation fee
Not disclosed
None
FDA warning letters
None on record
None on record
Provider facts checked
August 2026
August 2026
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose PlexusDx if…
- Optional Precision Peptide genetic panel adds a personalization angle
- Independent clinician review via state-licensed telehealth platform
- Compounded medications from state-licensed pharmacies
What to weigh up
- Compounded medications only; no FDA-approved brand options
- Specific compounding pharmacies not named
Choose RxSpan MD if…
- Lists oral compounded semaglutide, oral compounded tirzepatide and brand-name Wegovy / Ozempic, which PlexusDx doesn't price
- Physician-led — founded by Dr. John Diaz, a board-certified plastic surgeon with 20+ years' experience
- Names its 503A pharmacy partners (Belmar, Strive, Epiq Scripts, Casa Pharma) and medical group
What to weigh up
- Compounded pricing ($249 semaglutide / $329 tirzepatide) sits mid-to-high versus the cheapest telehealth options
- Brand-name GLP-1 is priced steeply (Wegovy $1,349, Ozempic $1,299, Zepbound $1,069)
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
PlexusDx
7.0/10
RxSpan MD
8.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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From $249/mo
Get started →Ro
FDA-approved brand GLP-1s, including the Wegovy pill and Foundayo, with insurance help
Read full review →From $149/mo (+ required membership)
Get started →ShedRx
Compounded GLP-1 as an injection, drops or lozenges, with lower rates on 6- and 12-month plans
Read full review →From $299/mo (after intro offer)
Get started →PlexusDx vs RxSpan MD: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking, or alternatives to PlexusDx and RxSpan MD.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.