RxSpan MD vs TMates
In our scoring, RxSpan MD edges ahead overall (8.1 vs 6.9 out of 10), and both cost the same for compounded semaglutide.
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Key differences
- Price
- Both $249/mo for compounded semaglutide (standing prices, no prepay listed)
- Coverage
- Both serve the same 50 states
- Included
- RxSpan MD: medication, clinician visits, shipping, coaching; TMates: medication, clinician visits, shipping, coaching
RxSpan MD
Affiliate partnerBest for physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
semaglutide
$249
Our score 8.1/10
TMates
Affiliate partnerBest for nationwide compounded GLP-1 availability including Puerto Rico
semaglutide
$249
Our score 6.9/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
RxSpan MD
TMates
Price
Semaglutide / month
$249/mo
$249/mo
Semaglutide / year (modeled)
$2,988
$2,988
Tirzepatide / month
$329/mo
Better on this row: $297/mo
Tirzepatide / year (modeled)
$3,948
Better on this row: $3,564
Oral semaglutide / month
$249/mo
Not listed
Oral tirzepatide / month
$349/mo
Not listed
Brand Wegovy / Ozempic / month
$1,299/mo
Not listed
Brand Zepbound / Mounjaro / month
$1,069/mo
Not listed
Coverage
State availability
50 states
50 states
Oral option listed
Yes
Not listed
Brand-name access listed
Wegovy / Ozempic, Zepbound / Mounjaro
Not listed
Included in the price
Medication, clinician visits, shipping, coaching
Medication, clinician visits, shipping, coaching
Terms & safety
Price shown
Before intake
Before intake
Cancel anytime
Yes
Yes
Minimum commitment
None
None
Early-cancellation fee
None
Not disclosed
FDA warning letters
None on record
None on record
Provider facts checked
August 2026
August 2026
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose RxSpan MD if…
- Lists oral compounded semaglutide, oral compounded tirzepatide and brand-name Wegovy / Ozempic, which TMates doesn't price
- Physician-led — founded by Dr. John Diaz, a board-certified plastic surgeon with 20+ years' experience
- Names its 503A pharmacy partners (Belmar, Strive, Epiq Scripts, Casa Pharma) and medical group
What to weigh up
- Compounded pricing ($249 semaglutide / $329 tirzepatide) sits mid-to-high versus the cheapest telehealth options
- Brand-name GLP-1 is priced steeply (Wegovy $1,349, Ozempic $1,299, Zepbound $1,069)
Choose TMates if…
- All-inclusive monthly price covers medication, consults, nutrition coaching, and 24/7 support — no separate membership fee
- Fast stated turnaround — 2–3 days from intake to delivery
What to weigh up
- No third-party pharmacy accreditation (no LegitScript, PCAB, ACHC, or NABP)
- BBB rating of B+ (not accredited) with complaints centered on billing and cancellation
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
RxSpan MD
8.1/10
TMates
6.9/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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Collective
The lowest flat medication price if you can absorb an annual membership fee
Read full review →From $59/mo + membership
Get started →From $219/mo
Get started →Found
Compounded GLP-1 with medication included from $169/mo cash, plus insurance help for brand GLP-1s
Read full review →From $169/mo
Get started →RxSpan MD vs TMates: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.