Lttl vs RxSpan MD
In our scoring, RxSpan MD edges ahead overall (8.1 vs 7.2 out of 10), and Lttl costs less for compounded semaglutide (about $1,701 a year less; one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost).
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Key differences
- Price
- Lttl $99/mo vs RxSpan MD $249/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $1,701 a year less with Lttl · one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost)
- Coverage
- RxSpan MD 50 states (Lttl doesn't publish a state list)
- Included
- Lttl: medication, clinician visits, shipping; RxSpan MD: medication, clinician visits, shipping, coaching

Lttl
Affiliate partnerBest for every commitment tier priced openly, plus a low-dose microdose option
semaglutide
$99
billed every 4 weeks
Our score 7.2/10

RxSpan MD
Affiliate partnerBest for physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
semaglutide
$249
Our score 8.1/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Lttl
RxSpan MD
Price
Semaglutide / month
Better on this row: $99/mo
billed every 4 weeks
$249/mo
Semaglutide / year (modeled)
Better on this row: $1,287
13 charges
$2,988
Tirzepatide / month
Better on this row: $149/mo
billed every 4 weeks
$329/mo
Tirzepatide / year (modeled)
Better on this row: $1,937
13 charges
$3,948
Oral semaglutide / month
Better on this row: $179/mo
$149 first month
$249/mo
Oral semaglutide / year (modeled)
Better on this row: $2,148
$2,988
Oral tirzepatide / month
Not listed
$349/mo
Brand Wegovy / Ozempic / month
Not listed
$1,299/mo
Brand Zepbound / Mounjaro / month
Not listed
$1,069/mo
Coverage
State availability
List not published
50 states
Oral option listed
Yes
Yes
Brand-name access listed
Not listed
Wegovy / Ozempic, Zepbound / Mounjaro
Included in the price
Medication, clinician visits, shipping
Medication, clinician visits, shipping, coaching
FSA/HSA accepted
Yes
Not listed
Terms & safety
Price shown
Before intake
Before intake
Cancel anytime
Yes
Yes
Minimum commitment
None on the monthly plan; 3-, 6- and 12-month prepay tiers offered at lower per-month rates
None
Early-cancellation fee
Not disclosed
None
FDA warning letters
None on record
None on record
Provider facts checked
October 2026
August 2026
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.

Choose Lttl if…
- About $1,701 a year less than RxSpan MD for compounded semaglutide at standing prices (one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost)
- Accepts FSA/HSA cards
- Publishes the full price matrix — every medication, form and commitment length — on a public /plans page before checkout
What to weigh up
- No published state list; confirm yours at signup
- Partner pharmacies are never named — the site refers only to 'a partner U.S. pharmacy' (a material disclosure gap for a YMYL purchase)

Choose RxSpan MD if…
- Lists oral compounded tirzepatide, brand-name Wegovy / Ozempic and brand-name Zepbound / Mounjaro, which Lttl doesn't price
- Publishes its full state list (50 states)
- Physician-led — founded by Dr. John Diaz, a board-certified plastic surgeon with 20+ years' experience
What to weigh up
- About $1,701 a year more than Lttl for compounded semaglutide (one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost)
- Compounded pricing ($249 semaglutide / $329 tirzepatide) sits mid-to-high versus the cheapest telehealth options
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Lttl
7.2/10
RxSpan MD
8.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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Collective
The lowest flat medication price if you can absorb an annual membership fee
Read full review →From $59/mo + membership
Get started →From $219/mo
Get started →Found
Compounded GLP-1 with medication included from $169/mo cash, plus insurance help for brand GLP-1s
Read full review →From $169/mo
Get started →Lttl vs RxSpan MD: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.