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Lttl vs RxSpan MD

In our scoring, RxSpan MD edges ahead overall (8.1 vs 7.2 out of 10), and Lttl costs less for compounded semaglutide (about $1,701 a year less; one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost).

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By Eli Marsden · Founding Editor
Editorially reviewed & fact-checked against primary sources · How we verify contentLast reviewed

Key differences

Price
Lttl $99/mo vs RxSpan MD $249/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $1,701 a year less with Lttl · one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost)
Coverage
RxSpan MD 50 states (Lttl doesn't publish a state list)
Included
Lttl: medication, clinician visits, shipping; RxSpan MD: medication, clinician visits, shipping, coaching

How we compare providers

Lttl logo

Lttl

Affiliate partner

Best for every commitment tier priced openly, plus a low-dose microdose option

semaglutide

$99/mo

billed every 4 weeks

Our score 7.2/10

RxSpan MD logo

RxSpan MD

Affiliate partner

Best for physician-led, pharmacy-transparent compounded GLP-1 with brand-name options

semaglutide

$249/mo

Our score 8.1/10

We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.

Costs & coverage

Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.

Lttl

RxSpan MD

Price

Semaglutide / month

Better on this row: $99/mo

billed every 4 weeks

$249/mo

Semaglutide / year (modeled)

Better on this row: $1,287

13 charges

$2,988

Tirzepatide / month

Better on this row: $149/mo

billed every 4 weeks

$329/mo

Tirzepatide / year (modeled)

Better on this row: $1,937

13 charges

$3,948

Oral semaglutide / month

Better on this row: $179/mo

$149 first month

$249/mo

Oral semaglutide / year (modeled)

Better on this row: $2,148

$2,988

Oral tirzepatide / month

Not listed

$349/mo

Brand Wegovy / Ozempic / month

Not listed

$1,299/mo

Brand Zepbound / Mounjaro / month

Not listed

$1,069/mo

Coverage

State availability

List not published

50 states

Oral option listed

Yes

Yes

Brand-name access listed

Not listed

Wegovy / Ozempic, Zepbound / Mounjaro

Included in the price

Medication, clinician visits, shipping

Medication, clinician visits, shipping, coaching

FSA/HSA accepted

Yes

Not listed

Terms & safety

Price shown

Before intake

Before intake

Cancel anytime

Yes

Yes

Minimum commitment

None on the monthly plan; 3-, 6- and 12-month prepay tiers offered at lower per-month rates

None

Early-cancellation fee

Not disclosed

None

FDA warning letters

None on record

None on record

Provider facts checked

October 2026

August 2026

Every dose and plan: Lttl · RxSpan MD

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Which fits your priorities?

Only the points where these two differ, from the table above and each provider’s record.

Lttl logo

Choose Lttl if…

  • About $1,701 a year less than RxSpan MD for compounded semaglutide at standing prices (one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost)
  • Accepts FSA/HSA cards
  • Publishes the full price matrix — every medication, form and commitment length — on a public /plans page before checkout

What to weigh up

  • No published state list; confirm yours at signup
  • Partner pharmacies are never named — the site refers only to 'a partner U.S. pharmacy' (a material disclosure gap for a YMYL purchase)
RxSpan MD logo

Choose RxSpan MD if…

  • Lists oral compounded tirzepatide, brand-name Wegovy / Ozempic and brand-name Zepbound / Mounjaro, which Lttl doesn't price
  • Publishes its full state list (50 states)
  • Physician-led — founded by Dr. John Diaz, a board-certified plastic surgeon with 20+ years' experience

What to weigh up

  • About $1,701 a year more than Lttl for compounded semaglutide (one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost)
  • Compounded pricing ($249 semaglutide / $329 tirzepatide) sits mid-to-high versus the cheapest telehealth options

Explore the scoring factors

Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.

Lttl

7.2/10

Overall

RxSpan MD

8.1/10

Value25%

7.0A
vs
B
7.0

Effectiveness25%

7.5A
vs
B
8.5

User Experience15%

8.0A
vs
B
7.5

Trust & Safety15%

6.5A
vs
B
9.3

Accessibility10%

6.5A
vs
B
8.5

Support10%

7.0A
vs
B
8.9

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Compounded GLP-1 in both injection and oral forms

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Lttl vs RxSpan MD: FAQ

For compounded semaglutide, Lttl costs less: about $1,701 less a year at the standing price, with no prepay or separate membership listed (not a first-month promo); one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost. See Costs & coverage above for each medication side by side.
RxSpan MD scores higher overall at 8.1/10 versus 7.2/10, and is particularly strong for physician-led, pharmacy-transparent compounded GLP-1 with brand-name options. That said, Lttl is a better fit if you want every commitment tier priced openly, plus a low-dose microdose option.
Both Lttl and RxSpan MD are affiliate partners, meaning we may earn a commission if you sign up through our links. Our scores are assigned editorially using the same six-dimension framework for every provider — partnership never changes a score. We disclose every commercial relationship.
Lttl: $99 (billed every 4 weeks, 13 charges a year), about $1,287 a year. RxSpan MD: $249, about $2,988 a year. Lttl costs about $1,701 less a year at these prices.
Lttl doesn't publish a state list. RxSpan MD publishes 50 states. Where a list isn't published, confirm your state during sign-up before paying.
Lttl: cancel anytime — yes; minimum commitment — None on the monthly plan; 3-, 6- and 12-month prepay tiers offered at lower per-month rates; early-cancellation fee — not disclosed. RxSpan MD: cancel anytime — yes; minimum commitment — None; early-cancellation fee — none. Check the provider's own terms before you buy.

Key terms, explained

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Continue exploring Lttl and RxSpan MD head-to-heads in the same category.

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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.