NewSelf vs RxSpan MD
Our featured pick: RxSpan MD (affiliate partner). In our scoring, NewSelf scores 8.2 and RxSpan MD 8.1 out of 10.
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Key differences
- Price
- NewSelf $100/mo on a 3-month prepaid plan; RxSpan MD $249/mo no prepay listed (compounded semaglutide · not like-for-like, so neither is marked cheaper)
- Coverage
- NewSelf 48 states + PR; RxSpan MD 50 states (only NewSelf: PR · only RxSpan MD: Louisiana and Mississippi)
- Included
- NewSelf: medication, clinician visits, shipping; RxSpan MD: medication, clinician visits, shipping, coaching
- Safety
- FDA warning letters on record: NewSelf 1, RxSpan MD none
NewSelf
Best for lowest-cost compounded GLP-1 at one price for every dose, if a 3-month commitment works for you
semaglutide
$100
on a 3-month prepaid plan
Our score 8.2/10
RxSpan MD
Affiliate partnerBest for physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
semaglutide
$249
Our score 8.1/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
NewSelf
RxSpan MD
Price
Semaglutide / month
$100/mo
on a 3-month prepaid plan
$249/mo
Semaglutide / year (modeled)
$1,200
$2,988
Tirzepatide / month
$144/mo
on a 3-month prepaid plan
$329/mo
Tirzepatide / year (modeled)
$1,728
$3,948
Oral semaglutide / month
Not listed
$249/mo
Oral tirzepatide / month
Not listed
$349/mo
Brand Wegovy / Ozempic / month
Not listed
$1,299/mo
Brand Zepbound / Mounjaro / month
Not listed
$1,069/mo
Coverage
State availability
48 states + PR
50 states
Oral option listed
Not listed
Yes
Brand-name access listed
Not listed
Wegovy / Ozempic, Zepbound / Mounjaro
Included in the price
Medication, clinician visits, shipping
Medication, clinician visits, shipping, coaching
Terms & safety
Price shown
Before intake
Before intake
Cancel anytime
No
Better on this row: Yes
Minimum commitment
3-month plan for the listed price
None
Refunds
No refunds after the doctor visit; full refund if the doctor declines; $99 fee if you cancel before the visit
Not disclosed
Early-cancellation fee
Yes
Better on this row: None
FDA warning letters
1 warning letter
Better on this row: None on record
Provider facts checked
October 2026
August 2026
Show where they differ by stateHide state lists
Only NewSelf (PR)
- PR
Only RxSpan MD (2 states)
- Louisiana
- Mississippi
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose NewSelf if…
- Serves PR, where RxSpan MD doesn't
- Same price at every dose, so your bill doesn't rise as you titrate up
- No membership fee; the visit, medication and shipping are bundled
What to weigh up
- 1 FDA warning letter on record
- Its $100/mo compounded semaglutide price needs a 3-month prepaid plan
Choose RxSpan MD if…
- Its $249/mo compounded semaglutide price needs no prepay; NewSelf's $100 needs a 3-month prepay
- Lists oral compounded semaglutide, oral compounded tirzepatide and brand-name Wegovy / Ozempic, which NewSelf doesn't price
- Serves Louisiana and Mississippi, where NewSelf doesn't
What to weigh up
- Not available in PR
- Compounded pricing ($249 semaglutide / $329 tirzepatide) sits mid-to-high versus the cheapest telehealth options
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
NewSelf
8.2/10
RxSpan MD
8.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Ready to start? Vetted GLP-1 providers
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Gala
Compounded semaglutide or tirzepatide at one all-doses price on a yearly plan, with free shipping
Read full review →From $129/mo (starting dose)
Get started →Found
Medication-included compounded GLP-1 from $169/mo on a 12-month prepaid plan, plus brand insurance help
Read full review →From $169/mo (12-month plan rate)
Get started →Oak
Compounded semaglutide and tirzepatide at a low starting price, with a full price list before you sign up
Read full review →From $200/mo (starting dose)
Get started →NewSelf vs RxSpan MD: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking, or alternatives to NewSelf and RxSpan MD.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.