RxSpan MD vs TrimRx
In our scoring, RxSpan MD edges ahead overall (8.1 vs 7.7 out of 10), and TrimRx costs less for compounded semaglutide (about $840 a year less).
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Key differences
- Price
- TrimRx $179/mo vs RxSpan MD $249/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $840 a year less with TrimRx)
- Coverage
- RxSpan MD 50 states (TrimRx doesn't publish a state list)
- Included
- RxSpan MD: medication, clinician visits, shipping, coaching; TrimRx: medication, clinician visits, shipping
RxSpan MD
Affiliate partnerBest for physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
semaglutide
$249
Our score 8.1/10
TrimRx
Affiliate partnerBest for best overall value
semaglutide
$179
$149 first month
Our score 7.7/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
RxSpan MD
TrimRx
Price
Semaglutide / month
$249/mo
Better on this row: $179/mo
$149 first month
Semaglutide / year (modeled)
$2,988
Better on this row: $2,148
Tirzepatide / month
$329/mo
Better on this row: $259/mo
Tirzepatide / year (modeled)
$3,948
Better on this row: $3,108
Brand Wegovy / Ozempic / month
Better on this row: $1,299/mo
$1,579/mo
Brand Wegovy / Ozempic / year (modeled)
Better on this row: $15,588
$18,948
Brand Zepbound / Mounjaro / month
Better on this row: $1,069/mo
$1,249/mo
Brand Zepbound / Mounjaro / year (modeled)
Better on this row: $12,828
$14,988
Oral semaglutide / month
$249/mo
Not listed
Oral tirzepatide / month
$349/mo
Not listed
Coverage
State availability
50 states
List not published
Oral option listed
Yes
Not listed
Brand-name access listed
Wegovy / Ozempic, Zepbound / Mounjaro
Wegovy / Ozempic, Zepbound / Mounjaro
Included in the price
Medication, clinician visits, shipping, coaching
Medication, clinician visits, shipping
Terms & safety
Price shown
Before intake
Before intake
Cancel anytime
Yes
Not disclosed
Minimum commitment
None
Not disclosed
Early-cancellation fee
None
Not disclosed
FDA warning letters
None on record
None on record
Provider facts checked
August 2026
August 2026
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose RxSpan MD if…
- Lists oral compounded semaglutide and oral compounded tirzepatide, which TrimRx doesn't price
- Publishes its full state list (50 states)
- Physician-led — founded by Dr. John Diaz, a board-certified plastic surgeon with 20+ years' experience
What to weigh up
- About $840 a year more than TrimRx for compounded semaglutide
- Compounded pricing ($249 semaglutide / $329 tirzepatide) sits mid-to-high versus the cheapest telehealth options
Choose TrimRx if…
- About $840 a year less than RxSpan MD for compounded semaglutide at standing prices
- Free shipping with medication delivered to your door monthly — can start as soon as the next day
- Price-stability promise: "switch and keep your current dose," with no advertised mid-program price hikes
What to weigh up
- No published state list; confirm yours at signup
- Async, questionnaire-based intake — no mandatory video visit with a clinician before prescribing
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
RxSpan MD
8.1/10
TrimRx
7.7/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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Collective
The lowest flat medication price if you can absorb an annual membership fee
Read full review →From $59/mo + membership
Get started →From $219/mo
Get started →Found
Compounded GLP-1 with medication included from $169/mo cash, plus insurance help for brand GLP-1s
Read full review →From $169/mo
Get started →RxSpan MD vs TrimRx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.