Best Semaglutide 1mg Providers — Ranked & Reviewed
The 1mg therapeutic dose is one of the most-searched semaglutide tiers. We compare every telehealth provider that offers compounded or brand-name semaglutide at this dose, ranked by independent score, monthly price, and patient reviews.
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Methodology & sources
Providers in this variant are scored against our published six-factor rubric[1], then filtered to match the specific dose shown in the page title.
Published Phase 3 efficacy for semaglutide 2.4 mg (~14.9% mean weight loss over 68 weeks) comes from the STEP 1 trial[2]. The SURMOUNT-5 head-to-head published in 2025 directly compared tirzepatide and semaglutide[3].
Quick Picks: Top 4
Detailed Reviews
CoreAge Rx
Best for: best overall value
CoreAge Rx offers LegitScript-verified compounded semaglutide and tirzepatide with free 2-day shipping to all 50 states. Backed by licensed physicians and 24/7 support, it delivers the most competitive pricing in the compounded GLP-1 space.
Score Breakdown
HydraMed
Best for: patients wanting all-in pricing with a single intake fee
HydraMed is a nationwide telehealth platform offering compounded semaglutide, tirzepatide, and a broader peptide menu including PT-141, GHK-Cu, and NAD+ in injection, nasal, and topical forms. All-inclusive monthly pricing covers prescription and supplies, free shipping, and a quick medical questionnaire intake. Compounding is performed at a US FDA-registered pharmacy. Also offers mobile IV services in CO, FL, TN, and WY.
Score Breakdown
PeptidesRx
Best for: patients prioritizing regulatory compliance in the compounded space
PeptidesRx is a Fort Worth, TX-based licensed telehealth platform offering physician-supervised compounded semaglutide, tirzepatide, and a broader prescription peptide menu. Board-certified medical director, licensed nurse practitioners conducting good-faith examinations, transparent pricing, and shipped directly to patients nationwide. Positions itself as a compliance-focused alternative to gray-market peptide vendors.
Score Breakdown
Invigor Medical
Best for: patients wanting an established multi-service clinic over a GLP-1-only specialist
Invigor Medical is a Pasco, WA-based nationwide telehealth provider offering compounded semaglutide and tirzepatide for weight loss alongside peptide therapy and sexual wellness treatments. Established clinic with multi-year operating history and licensed providers in all 50 states.
Score Breakdown
Frequently Asked Questions
Sources & methodology — as of April 2026
- 1.Weight Loss Rankings — GLP-1 Pricing Index 2026 (our independent dataset)— WeightLossRankings.org.
- 2.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 3.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.