Updated August 26, 2026Expert Reviewed

Best Semaglutide 0.5mg Providers in 2026 — Ranked & Reviewed

The 0.5mg step-up dose is one of the most-searched semaglutide tiers. We compare every telehealth provider that offers compounded or brand-name semaglutide at this dose, ranked by independent score, monthly price, and patient reviews.

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By Eli Marsden · Founding Editor
Editorially reviewed & fact-checked against primary sources · How we verify contentLast reviewed

1 semaglutide providers compared · independently scored against our six-factor methodology.

Always verify pricing and state availability on the provider's website before signing up.How our reviews work →

Methodology & sources

Providers in this variant are scored against our published six-factor rubric[1], then filtered to match the specific dose shown in the page title.

Published Phase 3 efficacy for semaglutide 2.4 mg (~14.9% mean weight loss over 68 weeks) comes from the STEP 1 trial[2]. The SURMOUNT-5 head-to-head published in 2025 directly compared tirzepatide and semaglutide[3].

Quick Picks: Top 1

#ProviderScore
1Coby HealthVisit

Detailed Reviews

1

Coby Health

Best for: cash-pay compounded GLP-1 at aggressive bundle pricing

7.4

Chicago/Springfield IL DTC telehealth marketplace (Coby Health LLC, BBB file opened 3/2025) offering compounded semaglutide from $99/mo (6-mo bundle, 0.25mg) and compounded tirzepatide from $179/mo (6-mo bundle, 2.5mg). LegitScript Certified (seal 38387067). Clinical care via Beluga Health P.A. (Dr. Jonah Mink network). No membership fee. CAUTION: does NOT publicly disclose compounding pharmacy partners.

Score Breakdown

Value25%
8
Effectiveness25%
7
User Experience15%
7.5
Trust & Safety15%
6
Accessibility10%
7.5
Support10%
8.4
0.5mg from $199/moRead full review →
Visit Coby Health →
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Frequently Asked Questions

Pricing varies by provider and form. Compounded semaglutide 0.5mg typically ranges from $149–$399/month, while brand-name Wegovy or Ozempic at this dose can run $900–$1,400/month without insurance.
Step-Up Dose — see the full dose escalation timeline at /dose-timeline.
Sources & methodology — as of August 2026
  1. 1.Weight Loss Rankings — GLP-1 Pricing Index 2026 (our independent dataset)— WeightLossRankings.org.
  2. 2.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
  3. 3.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.