Updated April 12, 2026Expert Reviewed

Best Semaglutide 0.5mg Providers — Ranked & Reviewed

The 0.5mg step-up dose is one of the most-searched semaglutide tiers. We compare every telehealth provider that offers compounded or brand-name semaglutide at this dose, ranked by independent score, monthly price, and patient reviews.

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Methodology & sources

Providers in this variant are scored against our published six-factor rubric[1], then filtered to match the specific dose shown in the page title.

Published Phase 3 efficacy for semaglutide 2.4 mg (~14.9% mean weight loss over 68 weeks) comes from the STEP 1 trial[2]. The SURMOUNT-5 head-to-head published in 2025 directly compared tirzepatide and semaglutide[3].

Quick Picks: Top 1

#ProviderScore
1CoreAge Rx9.0Visit

Detailed Reviews

1

CoreAge Rx

Best for: best overall value

9.0

CoreAge Rx offers LegitScript-verified compounded semaglutide and tirzepatide with free 2-day shipping to all 50 states. Backed by licensed physicians and 24/7 support, it delivers the most competitive pricing in the compounded GLP-1 space.

Score Breakdown

Value25%
9.5
Effectiveness25%
8.5
User Experience15%
9
Trust & Safety15%
9
Accessibility10%
9
Support10%
8.5
0.5mg from $199/mo
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Frequently Asked Questions

Sources & methodology — as of April 2026
  1. 1.Weight Loss Rankings — GLP-1 Pricing Index 2026 (our independent dataset)— WeightLossRankings.org.
  2. 2.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
  3. 3.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.