Amazon One Medical vs TMates
An in-depth comparison of two leading GLP-1 Providers
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Amazon One Medical
Best for: the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings
Visit Amazon One Medical →
TMates
Best for: nationwide compounded GLP-1 availability including Puerto Rico
Visit TMates →Amazon One Medical and TMates are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Amazon One Medical starts lower at $149/mo versus $249/mo, and TMates is the option we'd start with for most patients. Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Amazon One Medical
TMates
Verbatim ladder: 1 Month $249 / 3 Months $217/mo Save 13% $650 / 6 Months $175/mo Save 30% $1050 / 12 Months $158/mo Save 37% $1900. Injectable or Oral, same price. Includes medication and ongoing support; free shipping; cancel anytime. UNCHANGED vs providers.json pricing rows; providers.json description field's '$199/mo' is stale.
Verbatim ladder: 1 Month $297 / 3 Months $267/mo Save 10% $800 / 6 Months $217/mo Save 27% $1299 / 12 Months $167/mo Save 44% $1999. Injectable or Oral, same price. UNCHANGED vs providers.json.
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What’s included
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
TMates
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Amazon One Medical
8.5/10
TMates
6.9/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Amazon One Medical | TMates |
|---|---|---|
| Starting Price | ✓$149/mo | $249/mo |
| Features | ✓6 features | 4 features |
| States Available | 50 | 50 |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →About TMates
TMates is a Miami-based telehealth platform offering compounded semaglutide ($249/mo) and tirzepatide ($297/mo) across all 50 states plus Puerto Rico, operating on a messaging-first model with independent licensed prescribers and third-party compounding pharmacies.
Read our full TMates review →Pros & Cons
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
TMates
What we like
- All-inclusive monthly price covers medication, consults, nutrition coaching, and 24/7 support — no separate membership fee
- Available in all 50 states plus Puerto Rico and other US territories
- Both compounded semaglutide and tirzepatide offered
- Fast stated turnaround — 2–3 days from intake to delivery
Watch-outs
- No third-party pharmacy accreditation (no LegitScript, PCAB, ACHC, or NABP)
- BBB rating of B+ (not accredited) with complaints centered on billing and cancellation
- Trustpilot reports of partial refunds and difficulty reaching support
- Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- Pharmacy partners not named; routes medical and dispensing to third parties
- Also sells testosterone and other wellness products — not GLP-1-focused
- Lowest per-month prices require prepaying for 6- or 12-month plans ($1,050-$1,999 upfront)
Our Verdict
TMates is our recommended choice here, particularly for nationwide compounded GLP-1 availability including Puerto Rico. Amazon One Medical is a solid alternative, especially if you want the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings — compare the six-dimension breakdown and pricing below to weigh them for your situation.
Choose Amazon One Medical if…
You want the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings and a starting price around $149/mo.
Choose TMates if…
You want nationwide compounded GLP-1 availability including Puerto Rico and a starting price around $249/mo.
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Get started →Amazon One Medical vs TMates: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.