Amazon One Medical vs TrimRx
An in-depth comparison of two leading GLP-1 Providers
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Amazon One Medical
Best for the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savingsStarting at $149/mo
TrimRx
Best for best overall valueStarting at $179/mo
Side-by-Side Comparison
| Feature | Amazon One Medical | TrimRx |
|---|---|---|
| Overall Score | ✓8.7/10 | 8.5/10 |
| Starting Price | ✓$149/mo | $179/mo |
| Editorial Rating | ✓4.4 ★ /5 | 4.3 ★ /5 |
| Features | 6 features | ✓7 features |
| States Available | ✓50 | 0 |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
TrimRx
What we like
- Compounded semaglutide prescribed by licensed US medical providers after an online medical-history review
- Free shipping with medication delivered to your door monthly — can start as soon as the next day
- Price-stability positioning: "switch and keep your current dose," with no advertised mid-program price hikes
- Tiered monthly pricing from ~$179/mo plus discounted multi-month bundles; no insurance required (cash-pay)
- 24/7 patient portal for support; publishes HIPAA, privacy, SMS, and terms policies
Watch-outs
- Async, questionnaire-based intake — no mandatory video visit with a clinician before prescribing
- Compounded semaglutide is not FDA-approved (the site discloses this) — it is not brand Wegovy or Ozempic
- Only compounded semaglutide injections are advertised — tirzepatide and oral options are not publicly listed
- Compounding pharmacy partner is not named, and the state-availability list is not published
- Pricing tiers and program details are gated behind the intake quiz; no LegitScript certification displayed
Our Verdict
Amazon One Medical edges out TrimRx with a higher overall score of 8.7/10 and is particularly strong for the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings. TrimRx remains a solid alternative, especially if you're looking for best overall value.
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.