PlexusDx vs TMates
In our scoring, PlexusDx edges ahead overall (7.0 vs 6.9 out of 10).
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Key differences
- Price
- PlexusDx $129/mo no prepay listed; TMates $249/mo no prepay listed (compounded semaglutide · not like-for-like, so neither is marked cheaper)
- Coverage
- Both serve the same 50 states
- Included
- PlexusDx: medication, clinician visits; TMates: medication, clinician visits, shipping, coaching
PlexusDx
Affiliate partnerBest for nationwide compounded GLP-1 with optional genetic-test personalization
semaglutide
$129
microdose plan
Our score 7.0/10
TMates
Affiliate partnerBest for nationwide compounded GLP-1 availability including Puerto Rico
semaglutide
$249
Our score 6.9/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
PlexusDx
TMates
Price
Semaglutide / month
$129/mo
microdose plan
$249/mo
Semaglutide / year (modeled)
$1,548
$2,988
Tirzepatide / month
$249/mo
starting dose
$297/mo
Tirzepatide / year (modeled)
$2,988
$3,564
Coverage
State availability
50 states
50 states
Included in the price
Medication, clinician visits
Medication, clinician visits, shipping, coaching
Terms & safety
Price shown
Before intake
Before intake
Cancel anytime
Not disclosed
Yes
Minimum commitment
Not disclosed
None
FDA warning letters
None on record
None on record
Provider facts checked
August 2026
August 2026
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose PlexusDx if…
- Optional Precision Peptide genetic panel adds a personalization angle
- Independent clinician review via state-licensed telehealth platform
- Compounded medications from state-licensed pharmacies
What to weigh up
- Compounded medications only; no FDA-approved brand options
- Specific compounding pharmacies not named
Choose TMates if…
- All-inclusive monthly price covers medication, consults, nutrition coaching, and 24/7 support — no separate membership fee
- Fast stated turnaround — 2–3 days from intake to delivery
What to weigh up
- No third-party pharmacy accreditation (no LegitScript, PCAB, ACHC, or NABP)
- BBB rating of B+ (not accredited) with complaints centered on billing and cancellation
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
PlexusDx
7.0/10
TMates
6.9/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online.
No insurance needed · vetted by our editors
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ShedRx
Compounded GLP-1 as an injection, drops or lozenges, with lower rates on 6- and 12-month plans
Read full review →From $299/mo (after intro offer)
Get started →bmiMD
One flat compounded GLP-1 price at every dose: semaglutide $159/mo month to month, $119/mo on a 12-month plan
Read full review →From $159/mo
Get started →altRX
Low-cost compounded GLP-1s with brand-name Zepbound, Wegovy and Ozempic as options
Read full review →From $89/mo
Get started →PlexusDx vs TMates: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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- TMates vs Amazon One Medical
- TMates vs Vytora Health
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Or see the full category ranking, or alternatives to PlexusDx and TMates.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.