NewSelf vs TMates
An in-depth comparison of two leading GLP-1 Providers
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NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →
TMates
Best for: nationwide compounded GLP-1 availability including Puerto Rico
Visit TMates →NewSelf and TMates are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $249/mo, and TMates is the option we'd start with for most patients. Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
NewSelf
All dosages same price
All dosages same price
TMates
Verbatim ladder: 1 Month $249 / 3 Months $217/mo Save 13% $650 / 6 Months $175/mo Save 30% $1050 / 12 Months $158/mo Save 37% $1900. Injectable or Oral, same price. Includes medication and ongoing support; free shipping; cancel anytime. UNCHANGED vs providers.json pricing rows; providers.json description field's '$199/mo' is stale.
Verbatim ladder: 1 Month $297 / 3 Months $267/mo Save 10% $800 / 6 Months $217/mo Save 27% $1299 / 12 Months $167/mo Save 44% $1999. Injectable or Oral, same price. UNCHANGED vs providers.json.
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What’s included
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
TMates
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
NewSelf
8.3/10
TMates
6.9/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | NewSelf | TMates |
|---|---|---|
| Starting Price | ✓$100/mo | $249/mo |
| Features | ✓6 features | 4 features |
| States Available | 49 | ✓50 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →About TMates
TMates is a Miami-based telehealth platform offering compounded semaglutide ($249/mo) and tirzepatide ($297/mo) across all 50 states plus Puerto Rico, operating on a messaging-first model with independent licensed prescribers and third-party compounding pharmacies.
Read our full TMates review →Pros & Cons
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
TMates
What we like
- All-inclusive monthly price covers medication, consults, nutrition coaching, and 24/7 support — no separate membership fee
- Available in all 50 states plus Puerto Rico and other US territories
- Both compounded semaglutide and tirzepatide offered
- Fast stated turnaround — 2–3 days from intake to delivery
Watch-outs
- No third-party pharmacy accreditation (no LegitScript, PCAB, ACHC, or NABP)
- BBB rating of B+ (not accredited) with complaints centered on billing and cancellation
- Trustpilot reports of partial refunds and difficulty reaching support
- Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- Pharmacy partners not named; routes medical and dispensing to third parties
- Also sells testosterone and other wellness products — not GLP-1-focused
- Lowest per-month prices require prepaying for 6- or 12-month plans ($1,050-$1,999 upfront)
Our Verdict
TMates is our recommended choice here, particularly for nationwide compounded GLP-1 availability including Puerto Rico. NewSelf is a solid alternative, especially if you want lowest-cost compounded GLP-1 with pharmacy quality transparency — compare the six-dimension breakdown and pricing below to weigh them for your situation.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
Choose TMates if…
You want nationwide compounded GLP-1 availability including Puerto Rico and a starting price around $249/mo.
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Enhance MD
Lab-monitored compounded GLP-1 with mandatory video visit
From $112/mo
Get started →MEDVi
Patients who want the option to switch between compounded and brand-name GLP-1 through one provider
From $99/mo
Get started →Liv Body
Compounded GLP-1 paired with a muscle-preservation supplement stack
From $179/mo
Get started →NewSelf vs TMates: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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