Rylo Health vs Vytora Health
In our scoring, Vytora Health edges ahead overall (8.4 vs 7.7 out of 10), and Rylo Health costs less for compounded semaglutide (about $480 a year less).
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Key differences
- Price
- Rylo Health $139/mo vs Vytora Health $179/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $480 a year less with Rylo Health)
- Coverage
- Rylo Health 50 states; Vytora Health 50 states + DC (only Vytora Health: District of Columbia)
- Included
- Rylo Health: medication, clinician visits, shipping; Vytora Health: medication, clinician visits, shipping
Rylo Health
Best for shoppers who want the pharmacy and medical group named before they buy
semaglutide
$139
Our score 7.7/10
Vytora Health
Best for compounded or brand-name GLP-1 with named pharmacy partners, 50 states
semaglutide
$179
Our score 8.4/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Rylo Health
Vytora Health
Price
Semaglutide / month
Better on this row: $139/mo
$179/mo
Semaglutide / year (modeled)
Better on this row: $1,668
$2,148
Tirzepatide / month
Better on this row: $229/mo
$249/mo
Tirzepatide / year (modeled)
Better on this row: $2,748
$2,988
Brand Zepbound / Mounjaro / month
Not listed
$1,399/mo
Coverage
State availability
50 states
50 states + DC
Brand-name access listed
Not listed
Zepbound / Mounjaro
Included in the price
Medication, clinician visits, shipping
Medication, clinician visits, shipping
Terms & safety
Price shown
Before intake
Before intake
Cancel anytime
Yes
Yes
Minimum commitment
None on the monthly plan; the quarterly plan is billed every 3 months
None on monthly plans; 3-month plans are billed every 3 months
Refunds
Fully refundable before your first physician consultation; refunds if found medically ineligible
'All sales are final' for prescription products; refund requests 'reviewed on a case-by-case basis'
Early-cancellation fee
None
Not disclosed
FDA warning letters
None on record
None on record
Provider facts checked
October 2026
October 2026
Show where they differ by stateHide state lists
Only Vytora Health (DC)
- District of Columbia
Every dose and plan: Rylo Health · Vytora Health
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Rylo Health if…
- About $480 a year less than Vytora Health for compounded semaglutide at standing prices
- Names its dispensing pharmacy in full, with address and phone: VialsRX in Houston, Texas
- Names its medical group, Lone Star Virtual Health PLLC, and gives a provider contact
What to weigh up
- Not available in District of Columbia
- The headline $100 and $160 rates require paying for three months at once ($299 or $479)
Choose Vytora Health if…
- Lists brand-name Zepbound / Mounjaro, which Rylo Health doesn't price
- Serves District of Columbia, where Rylo Health doesn't
- Both compounded and brand-name options on one platform
What to weigh up
- About $480 a year more than Rylo Health for compounded semaglutide
- Brand-name Mounjaro and Zepbound at $1,399/mo are priced at retail; manufacturer self-pay programs are often cheaper
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Rylo Health
7.7/10
Vytora Health
8.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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From $247/mo (after intro offer)
Get started →From $139/mo (4-month plan rate)
Get started →From $299/mo (starting dose)
Get started →Rylo Health vs Vytora Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.