MariTide (Maridebart Cafraglutide)

Definition

Amgen's investigational once-monthly conjugate combining a GLP-1 receptor agonist with a GIP receptor antagonist. Phase 2 (NEJM 2025) reported 16-20% weight loss. The mechanism is unique: opposite GIP direction versus tirzepatide (which is a GIP agonist). Not yet FDA-approved.

GLP-1 pipeline: survodutide, MariTide, ecnoglutide →

Definition curated by Weight Loss Rankings — sourced from FDA labels and peer-reviewed PubMed literature, never AI-generated summaries.

Related terms in Drugs and brands

• Wegovy
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• Zepbound
• Mounjaro
• Foundayo
• Semaglutide
• Tirzepatide
• Orforglipron
• Retatrutide
• CagriSema
• Cagrilintide
• Survodutide
• Ecnoglutide

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• GLP-1 pipeline: survodutide, MariTide, ecnoglutide
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