Signos vs Collective
An in-depth comparison of two leading GLP-1 Providers
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Signos
Best for: Pairing compounded semaglutide with an FDA-cleared glucose monitor + app
Visit Signos →
Collective
Best for: the lowest flat medication price if you can absorb an annual membership fee
Visit Collective →Signos and Collective are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Collective starts lower at $59/mo versus $199/mo, and Collective edges ahead overall (8.3 vs 7.5 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Signos
Signos+ GLP-1 bundle (tirzepatide OR semaglutide) from $199/mo; includes CGM system
Collective
Verbatim: 'Compounded Semaglutide: $59/month. Same price, every dose. Cancel anytime.' ⛔ EXCLUDES the required membership — the site states 'What does it cost? $59/month + $199 annual membership.' First-year total is $907 ($75.58/mo equivalent).
Verbatim: 'Compounded Tirzepatide: $69/month. Same price, any dose.' ⛔ EXCLUDES the required membership — 'The cost is $69/month + $199 annual membership.' First-year total is $1,027 ($85.58/mo equivalent).
Verbatim: 'Requires Collective membership: 21 day free trial, then a low annual $199 membership fee. No recurring monthly membership charges.' Charged yearly, not monthly. Terms of Use: 'all membership fees are non-refundable, and partial-period refunds are not provided.'
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What’s included
Signos
What the monthly price covers
Medication
Included
Provider visits
Not disclosed
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Collective
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Signos
7.5/10
Collective
8.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Signos | Collective |
|---|---|---|
| Starting Price | $199/mo | ✓$59/mo |
| Features | ✓8 features | 3 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | ✓ Yes | — |
| FDA Warnings | None | None |
About Signos
Signos (Signos+) is a metabolic-health platform that bundles clinician-prescribed compounded GLP-1 (semaglutide) with an FDA-cleared continuous glucose monitor (CGM) and app — pairing the medication with real-time glucose data and coaching so users understand and sustain their weight loss. The program starts at $199/mo on a 6-month plan, includes free shipping, and is HSA/FSA eligible. It is pitched as the same price as medication alone, with the CGM added.
Read our full Signos review →About Collective
Collective (collective.org) is a membership-based telehealth platform from the founder of Thrive Market, selling compounded semaglutide and tirzepatide at a flat price on every dose. Medication is billed separately from a required annual membership, and the program bundles unlimited clinician messaging, dietitian access and express cold shipping.
Read our full Collective review →Pros & Cons
Signos
What we like
- Bundles compounded GLP-1 (semaglutide) with an FDA-cleared CGM and app — glucose-guided weight loss, not just medication
- Starting at $199/mo on a 6-month program, with the CGM included at no extra cost
- Free rapid shipping; HSA/FSA eligible
- Real-time glucose insights and app coaching to help sustain results after GLP-1
Watch-outs
- Compounded GLP-1s are not FDA-approved finished products
- Headline price is a 6-month-program rate, not month-to-month
- Only semaglutide is shown in the program; tirzepatide availability is not confirmed
- Compounding pharmacy partner and state availability are not published on the landing page
Collective
What we like
- The lowest published compounded GLP-1 medication prices we track — $59/month semaglutide and $69/month tirzepatide
- Flat pricing at every dose, so titrating up does not raise the bill
- Unlimited clinician messaging and registered-dietitian access are included rather than upsold
- 21-day free trial on the membership before the annual fee is charged
Watch-outs
- The advertised $59 and $69 exclude a mandatory $199 annual membership — the real first-year cost is $907 and $1,027
- Membership fees are non-refundable and no partial-period refunds are given
- Compounding pharmacies are described only as 'independent, third-party licensed pharmacies' and are never named
- State availability is not published on the marketing site
Our Verdict
Collective edges out Signos with a higher overall score of 8.3/10 and is particularly strong for the lowest flat medication price if you can absorb an annual membership fee. Signos remains a solid alternative, especially if you're looking for Pairing compounded semaglutide with an FDA-cleared glucose monitor + app.
Choose Signos if…
You want Pairing compounded semaglutide with an FDA-cleared glucose monitor + app and a starting price around $199/mo.
Choose Collective if…
You want the lowest flat medication price if you can absorb an annual membership fee and a starting price around $59/mo.
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PeterMD
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From $215.67/mo
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LGBTQ+-inclusive compounded GLP-1 telehealth
From $199/mo
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Lab-monitored compounded GLP-1 with mandatory video visit
From $112/mo
Get started →Signos vs Collective: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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