Signos vs Vytora Health
In our scoring, Vytora Health edges ahead overall (8.4 vs 7.5 out of 10).
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Key differences
- Price
- Signos $199/mo on a 6-month prepaid plan; Vytora Health $179/mo no prepay listed (compounded semaglutide · not like-for-like, so neither is marked cheaper)
- Coverage
- Signos 49 states + DC; Vytora Health 50 states + DC (only Vytora Health: Louisiana)
- Included
- Signos: medication, clinician visits, shipping; Vytora Health: medication, clinician visits, shipping
Signos
Best for Pairing compounded semaglutide or tirzepatide with a glucose monitor and coaching app
semaglutide
$199
on a 6-month prepaid plan · billed every 4 weeks
Our score 7.5/10
Vytora Health
Best for compounded or brand-name GLP-1 with named pharmacy partners, 50 states
semaglutide
$179
Our score 8.4/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Signos
Vytora Health
Price
Semaglutide / month
$199/mo
on a 6-month prepaid plan · billed every 4 weeks
$179/mo
Semaglutide / year (modeled)
$2,587
13 charges
$2,148
Tirzepatide / month
$199/mo
on a 6-month prepaid plan · billed every 4 weeks
$249/mo
Tirzepatide / year (modeled)
$2,587
13 charges
$2,988
Brand Zepbound / Mounjaro / month
Not listed
$1,399/mo
Coverage
State availability
49 states + DC
50 states + DC
Brand-name access listed
Not listed
Zepbound / Mounjaro
Included in the price
Medication, clinician visits, shipping
Medication, clinician visits, shipping
FSA/HSA accepted
Yes
Not listed
Terms & safety
Price shown
Before intake
Before intake
Cancel anytime
No
Better on this row: Yes
Minimum commitment
6-month plan for the listed price
None on monthly plans; 3-month plans are billed every 3 months
Refunds
All sales final; full refund if a clinician does not approve GLP-1 treatment
'All sales are final' for prescription products; refund requests 'reviewed on a case-by-case basis'
Early-cancellation fee
Yes
Not disclosed
FDA warning letters
None on record
None on record
Provider facts checked
October 2026
October 2026
Show where they differ by stateHide state lists
Only Vytora Health (1 state)
- Louisiana
Every dose and plan: Signos · Vytora Health
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Signos if…
- Accepts FSA/HSA cards
- Pairs compounded semaglutide or tirzepatide with an FDA-cleared CGM and app, so you see how your body responds
- Includes registered dietitian support and regular check-ins with licensed providers
What to weigh up
- Its $199/mo compounded semaglutide price needs a 6-month prepaid plan
- Not available in Louisiana
Choose Vytora Health if…
- Its $179/mo compounded semaglutide price needs no prepay; Signos' $199 needs a 6-month prepay
- Lists brand-name Zepbound / Mounjaro, which Signos doesn't price
- Serves Louisiana, where Signos doesn't
What to weigh up
- Brand-name Mounjaro and Zepbound at $1,399/mo are priced at retail; manufacturer self-pay programs are often cheaper
- Compounded tirzepatide at $249/mo month-to-month is mid-market
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Signos
7.5/10
Vytora Health
8.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Ready to start? Vetted GLP-1 providers
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Found
Compounded GLP-1 with medication included from $169/mo cash, plus insurance help for brand GLP-1s
Read full review →From $169/mo
Get started →GobyMeds
No-membership, no-auto-renew compounded GLP-1 orders, from about $99/mo on a 3-month bundle
Read full review →From $169/mo
Get started →Ivim Health
Compounded GLP-1 with weekly provider check-ins and health coaches, under a required monthly membership
Read full review →From $65/mo + membership
Get started →Signos vs Vytora Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.