Rylo Health vs Amazon One Medical
An in-depth comparison of two leading GLP-1 Providers
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Rylo Health
Best for: shoppers who want the pharmacy and medical group named before they buy
Visit Rylo Health →
Amazon One Medical
Best for: the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings
Visit Amazon One Medical →Rylo Health and Amazon One Medical are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, both start around $149/mo, and Amazon One Medical edges ahead overall (8.5 vs 7.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Rylo Health
Standard rate $149/mo; quarterly $349. A First 20 promotional rate of $100/mo is advertised for the first 20 patients.
Standard rate $249/mo; quarterly $499. A First 20 promotional rate of $160/mo is advertised for the first 20 patients.
Amazon One Medical
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What’s included
Rylo Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Rylo Health
7.7/10
Amazon One Medical
8.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Rylo Health | Amazon One Medical |
|---|---|---|
| Starting Price | $149/mo | $149/mo |
| Features | 4 features | ✓6 features |
| States Available | 50 | 50 |
| Compounded | ✓ Yes | — |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About Rylo Health
Texas-prescriber telehealth selling compounded semaglutide and tirzepatide alongside a peptide line, naming both its medical group and its dispensing pharmacy.
Read our full Rylo Health review →About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →Pros & Cons
Rylo Health
What we like
- Names its dispensing pharmacy in full, with address and phone: VialsRX in Houston, Texas
- Names its medical group, Lone Star Virtual Health PLLC, and gives a provider contact
- Standard prices published openly alongside the promotional rate, so the real ongoing cost is visible
- Cancel in one click from the patient portal, with no contracts and no cancellation fees
- Peptide line priced openly, including NAD+ and sermorelin
Watch-outs
- Headline $100 and $160 rates are limited to the first 20 patients; standard rates are $149 and $249
- No LegitScript certification is claimed or displayed
- Several peptide products are advertised as coming soon rather than available
- No published refund policy beyond the no-cancellation-fee statement
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
Our Verdict
Amazon One Medical edges out Rylo Health with a higher overall score of 8.5/10 and is particularly strong for the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings. Rylo Health remains a solid alternative, especially if you're looking for shoppers who want the pharmacy and medical group named before they buy.
Choose Rylo Health if…
You want shoppers who want the pharmacy and medical group named before they buy and a starting price around $149/mo.
Choose Amazon One Medical if…
You want the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings and a starting price around $149/mo.
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Budget-conscious shoppers
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Mainstream telehealth GLP-1 access
From $99/mo
Get started →Rylo Health vs Amazon One Medical: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.