One80Rx vs Amazon One Medical
An in-depth comparison of two leading GLP-1 Providers
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One80Rx
Best for: low listed GLP-1 prices with flat dosing, including microdose and oral options
Visit One80Rx →
Amazon One Medical
Best for: the most authoritative brand-name GLP-1 channel, with same-day delivery
Visit Amazon One Medical →One80Rx and Amazon One Medical are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, One80Rx starts lower at $129/mo versus $149/mo, and Amazon One Medical edges ahead overall (8.5 vs 6.8 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
One80Rx
Card reads "from $129/mo"; the site says plans are confirmed after provider review.
Card reads "from $229/mo"; the site says plans are confirmed after provider review.
Amazon One Medical
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What’s included
One80Rx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
One80Rx
6.8/10
Amazon One Medical
8.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | One80Rx | Amazon One Medical |
|---|---|---|
| Starting Price | ✓$129/mo | $149/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | 50 |
| Compounded | ✓ Yes | — |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About One80Rx
One80Rx is a Tampa-based telehealth platform selling compounded semaglutide and tirzepatide injections, plus a GLP-1 microdose program, an oral GLP-1 and a long list of peptides. Listed prices start at $129/mo for semaglutide and $229/mo for tirzepatide, and the site promises flat pricing with no dose-change surcharge. The catch is that every price is a "from" figure confirmed only after provider review, and the brand launched in mid-2026.
Read our full One80Rx review →About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →Pros & Cons
One80Rx
What we like
- Low listed entry prices: semaglutide from $129/mo and tirzepatide from $229/mo
- Flat-rate pricing is promised with no consultation fee and no surcharge when your dose goes up
- $0 if a provider does not approve you, and the Terms refund you if no prescription is issued
- Four GLP-1 formats, including a lower-dose microdose program and a daily oral option
- Free 2–3 day shipping in temperature-controlled, unmarked packaging
- Support phone line and email published, with weekday hours of 9 AM to 5 PM
- Cancel from your patient portal by turning off auto-refill at least 48 hours before the next charge
Watch-outs
- Every price is a "from" figure confirmed only after provider review; the treatment pages show no price at all
- No price appears in the intake before it asks for your name, email, phone, birth date and shipping address
- Neither the compounding pharmacy nor the prescribing medical group is named anywhere on the site
- Shows a Trustpilot "4.8 / 5" rating, but no Trustpilot profile for the brand could be found
- Brand launched in mid-2026, yet the homepage claims "10k+" members beside a "1,743+ patients supported" counter
- Terms make you waive the right to fill your prescription at a pharmacy of your choice
- No refunds once medication is dispensed, and order cancellation is limited to 24 hours after purchase
- Compounded semaglutide and tirzepatide are not FDA-approved, as the site itself states
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
Our Verdict
Amazon One Medical edges out One80Rx with a higher overall score of 8.5/10 and is particularly strong for the most authoritative brand-name GLP-1 channel, with same-day delivery. One80Rx remains a solid alternative, especially if you're looking for low listed GLP-1 prices with flat dosing, including microdose and oral options.
Choose One80Rx if…
You want low listed GLP-1 prices with flat dosing, including microdose and oral options and a starting price around $129/mo.
Choose Amazon One Medical if…
You want the most authoritative brand-name GLP-1 channel, with same-day delivery and a starting price around $149/mo.
Ready to start? Vetted GLP-1 providers
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Found
Mainstream telehealth GLP-1 access
From $99/mo
Get started →Bodybuilding Health+
Fitness-brand compounded GLP-1 with hormone and performance programs
From $179/mo
Get started →Brightmeds
Compounded or brand GLP-1 bundled with TRT and peptides for men
From $100/mo
Get started →One80Rx vs Amazon One Medical: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.