One80Rx vs Vytora Health
An in-depth comparison of two leading GLP-1 Providers
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One80Rx
Best for: low listed GLP-1 prices with flat dosing, including microdose and oral options
Visit One80Rx →
Vytora Health
Best for: compounded or brand-name GLP-1 with named pharmacy partners, 50 states
Visit Vytora Health →One80Rx and Vytora Health are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, One80Rx starts lower at $129/mo versus $150/mo, and Vytora Health edges ahead overall (8.4 vs 6.8 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
One80Rx
Card reads "from $129/mo"; the site says plans are confirmed after provider review.
Card reads "from $229/mo"; the site says plans are confirmed after provider review.
Vytora Health
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What’s included
One80Rx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Vytora Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
One80Rx
6.8/10
Vytora Health
8.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | One80Rx | Vytora Health |
|---|---|---|
| Starting Price | ✓$129/mo | $150/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 51 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About One80Rx
One80Rx is a Tampa-based telehealth platform selling compounded semaglutide and tirzepatide injections, plus a GLP-1 microdose program, an oral GLP-1 and a long list of peptides. Listed prices start at $129/mo for semaglutide and $229/mo for tirzepatide, and the site promises flat pricing with no dose-change surcharge. The catch is that every price is a "from" figure confirmed only after provider review, and the brand launched in mid-2026.
Read our full One80Rx review →About Vytora Health
Vytora Health is a 50-state-plus-DC telehealth platform offering compounded semaglutide and tirzepatide alongside brand-name Mounjaro and Zepbound, plus NAD+ and sermorelin peptides. It names its pharmacy partners publicly — Vials Pharmacy and Greenwich Biosciences — and discloses its operating physician group, uncommon transparency for the category. Compounded semaglutide runs $180/mo ($150 on a 3-month bundle) and tirzepatide $249/mo ($200 bundled).
Read our full Vytora Health review →Pros & Cons
One80Rx
What we like
- Low listed entry prices: semaglutide from $129/mo and tirzepatide from $229/mo
- Flat-rate pricing is promised with no consultation fee and no surcharge when your dose goes up
- $0 if a provider does not approve you, and the Terms refund you if no prescription is issued
- Four GLP-1 formats, including a lower-dose microdose program and a daily oral option
- Free 2–3 day shipping in temperature-controlled, unmarked packaging
- Support phone line and email published, with weekday hours of 9 AM to 5 PM
- Cancel from your patient portal by turning off auto-refill at least 48 hours before the next charge
Watch-outs
- Every price is a "from" figure confirmed only after provider review; the treatment pages show no price at all
- No price appears in the intake before it asks for your name, email, phone, birth date and shipping address
- Neither the compounding pharmacy nor the prescribing medical group is named anywhere on the site
- Shows a Trustpilot "4.8 / 5" rating, but no Trustpilot profile for the brand could be found
- Brand launched in mid-2026, yet the homepage claims "10k+" members beside a "1,743+ patients supported" counter
- Terms make you waive the right to fill your prescription at a pharmacy of your choice
- No refunds once medication is dispensed, and order cancellation is limited to 24 hours after purchase
- Compounded semaglutide and tirzepatide are not FDA-approved, as the site itself states
Vytora Health
What we like
- All 50 states plus DC, with per-state video-vs-audio compliance disclosed
- Both compounded and brand-name options on one platform — uncommon
- LegitScript Approved and HIPAA compliant
- Pharmacy partners named publicly: Vials Pharmacy (TX) and Greenwich Biosciences
- Operating entity disclosed: Wasef Health, PC (Pinellas Park, FL)
- Competitive monthly pricing ($180 sema / $249 tirz) plus a 3-month bundle saving 17%
- Brand-name Mounjaro and Zepbound available at $1,399/mo for FDA-approved options
Watch-outs
- Brand-name Mounjaro/Zepbound at $1,399/mo is near retail — insured patients may do better via LillyDirect Self Pay ($449-$699/mo)
- Compounded tirzepatide at $249/mo is mid-market, above the $149-199 floor
- Dose tiers aren't broken out — 'all doses included' means low-dose patients pay the same as high-dose
- Initial consultation cost not shown on the public pricing page
- Limited per-prescriber state licensure detail
Our Verdict
Vytora Health edges out One80Rx with a higher overall score of 8.4/10 and is particularly strong for compounded or brand-name GLP-1 with named pharmacy partners, 50 states. One80Rx remains a solid alternative, especially if you're looking for low listed GLP-1 prices with flat dosing, including microdose and oral options.
Choose One80Rx if…
You want low listed GLP-1 prices with flat dosing, including microdose and oral options and a starting price around $129/mo.
Choose Vytora Health if…
You want compounded or brand-name GLP-1 with named pharmacy partners, 50 states and a starting price around $150/mo.
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Sesame Care
Brand-name GLP-1s at cash prices, no compounding
From $25/mo
Get started →Collective
The lowest flat medication price if you can absorb an annual membership fee
From $59/mo
Get started →Sunlight
Compounded GLP-1 with unlimited telehealth visits and free shipping
From $88/mo
Get started →One80Rx vs Vytora Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.