One80Rx vs Vytora Health
In our scoring, Vytora Health edges ahead overall (8.4 vs 6.8 out of 10).
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Key differences
- Price
- One80Rx $129/mo no prepay listed; Vytora Health $179/mo no prepay listed (compounded semaglutide · not like-for-like, so neither is marked cheaper)
- Coverage
- Vytora Health 50 states + DC (One80Rx doesn't publish a state list)
- Included
- One80Rx: medication, clinician visits, shipping; Vytora Health: medication, clinician visits, shipping
One80Rx
Best for low listed GLP-1 prices with flat dosing, including microdose and oral options
semaglutide
$129
“starting at” price
Our score 6.8/10
Vytora Health
Best for compounded or brand-name GLP-1 with named pharmacy partners, 50 states
semaglutide
$179
Our score 8.4/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
One80Rx
Vytora Health
Price
Semaglutide / month
$129/mo
“starting at” price
$179/mo
Semaglutide / year (modeled)
$1,548
$2,148
Tirzepatide / month
$229/mo
“starting at” price
$249/mo
Tirzepatide / year (modeled)
$2,748
$2,988
Brand Zepbound / Mounjaro / month
Not listed
$1,399/mo
Coverage
State availability
List not published
50 states + DC
Brand-name access listed
Not listed
Zepbound / Mounjaro
Included in the price
Medication, clinician visits, shipping
Medication, clinician visits, shipping
Terms & safety
Price shown
Before intake
Before intake
Cancel anytime
Yes
Yes
Minimum commitment
None stated; recurring orders renew every 30 days until canceled
None on monthly plans; 3-month plans are billed every 3 months
Refunds
"Refunds will only be issued in the following situations: An incorrect prescription medication was sent. The product was damaged upon delivery. The product does not meet required safety standards. The order has not yet shipped. The prescribing Provider declines to issue a prescription."
'All sales are final' for prescription products; refund requests 'reviewed on a case-by-case basis'
Early-cancellation fee
None
Not disclosed
FDA warning letters
None on record
None on record
Provider facts checked
September 2026
October 2026
Every dose and plan: One80Rx · Vytora Health
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose One80Rx if…
- Flat-rate pricing is promised with no consultation fee and no surcharge when your dose goes up
- Four GLP-1 formats, including a lower-dose microdose program and a daily oral option
- Free 2–3 day shipping in temperature-controlled, unmarked packaging
What to weigh up
- No published state list; confirm yours at signup
- Every price is a "from" figure confirmed only after provider review; the treatment pages show no price at all
Choose Vytora Health if…
- Lists brand-name Zepbound / Mounjaro, which One80Rx doesn't price
- Publishes its full state list (50 states + DC)
- Both compounded and brand-name options on one platform
What to weigh up
- Brand-name Mounjaro and Zepbound at $1,399/mo are priced at retail; manufacturer self-pay programs are often cheaper
- Compounded tirzepatide at $249/mo month-to-month is mid-market
One80Rx and Vytora Health in context
One80Rx and Vytora Health both list compounded semaglutide, yet the figures are not like-for-like: one figure is a “starting at” price. We leave the cheaper-side call out rather than guess. For a like-for-like field, see the cheapest compounded semaglutide ranking. On score, One80Rx is at 6.8 and Vytora Health at 8.4 out of 10.
One80Rx states that its price stays the same at every dose. Vytora Health does not say either way, which matters once you titrate up; the flat-price GLP-1 list shows who else commits to one price. Vytora Health publishes where it ships (50 states + DC); One80Rx does not publish a state list, so confirm yours at intake or start from providers by state. Vytora Health has LegitScript certification on file and One80Rx does not, a point we weigh under trust in the Vytora Health review.
The next head-to-head for One80Rx is One80Rx vs Amazon One Medical; Amazon One Medical sells orforglipron and semaglutide and lists 50 states. For Vytora Health, it is Vytora Health vs OnlineSemaglutide.org; OnlineSemaglutide.org sells semaglutide and tirzepatide and lists 50 states. If neither fits, the wider shortlists are alternatives to One80Rx and alternatives to Vytora Health.
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
One80Rx
6.8/10
Vytora Health
8.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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Gala
Compounded semaglutide or tirzepatide at one all-doses price on a yearly plan, with free shipping
Read full review →From $129/mo (starting dose)
Get started →Found
Medication-included compounded GLP-1 from $169/mo on a 12-month prepaid plan, plus brand insurance help
Read full review →From $289/4 wks (billed per 4 weeks)
Get started →Oak
Compounded semaglutide and tirzepatide at a low starting price, with a full price list before you sign up
Read full review →From $200/mo (starting dose)
Get started →One80Rx vs Vytora Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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- One80Rx vs Amazon One Medical
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- Vytora Health vs Collective
Or see the full category ranking, or alternatives to One80Rx and Vytora Health.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.