Enhance MD vs TMates
In our scoring, Enhance MD edges ahead overall (8.2 vs 6.9 out of 10), and Enhance MD costs less for compounded semaglutide (about $444 a year less).
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Key differences
- Price
- Enhance MD $212/mo vs TMates $249/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $444 a year less with Enhance MD)
- Coverage
- Enhance MD 39 states; TMates 50 states (only TMates: Alabama, Arkansas, Georgia and 8 more)
- Included
- Enhance MD: medication, clinician visits, labs; TMates: medication, clinician visits, shipping, coaching
Enhance MD
Affiliate partnerBest for lab-monitored compounded GLP-1 with mandatory video visit
semaglutide
$212
$112 first month
Our score 8.2/10
TMates
Affiliate partnerBest for nationwide compounded GLP-1 availability including Puerto Rico
semaglutide
$249
Our score 6.9/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Enhance MD
TMates
Price
Semaglutide / month
Better on this row: $212/mo
$112 first month
$249/mo
Semaglutide / year (modeled)
Better on this row: $2,544
$2,988
Tirzepatide / month
Better on this row: $169/mo
$297/mo
Tirzepatide / year (modeled)
Better on this row: $2,028
$3,564
Coverage
State availability
39 states
50 states
Included in the price
Medication, clinician visits, labs
Medication, clinician visits, shipping, coaching
Terms & safety
Price shown
Before intake
Before intake
Lab work
Required
Not disclosed
Video visit
Required
Not disclosed
Cancel anytime
Yes
Yes
Minimum commitment
None
None
FDA warning letters
None on record
None on record
Provider facts checked
August 2026
August 2026
Show where they differ by stateHide state lists
Only TMates (11 states)
- Alabama
- Arkansas
- Georgia
- Hawaii
- Louisiana
- Mississippi
- Missouri
- North Dakota
- South Carolina
- Tennessee
- West Virginia
Every dose and plan: Enhance MD · TMates
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Enhance MD if…
- About $444 a year less than TMates for compounded semaglutide at standing prices
- Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
What to weigh up
- Not available in 11 states that TMates serves
- Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
Choose TMates if…
- Serves 11 states that Enhance MD doesn't
- All-inclusive monthly price covers medication, consults, nutrition coaching, and 24/7 support — no separate membership fee
- Fast stated turnaround — 2–3 days from intake to delivery
What to weigh up
- About $444 a year more than Enhance MD for compounded semaglutide
- No third-party pharmacy accreditation (no LegitScript, PCAB, ACHC, or NABP)
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Enhance MD
8.2/10
TMates
6.9/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online.
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From $219/mo
Get started →Found
Compounded GLP-1 with medication included from $169/mo cash, plus insurance help for brand GLP-1s
Read full review →From $169/mo
Get started →GobyMeds
No-membership, no-auto-renew compounded GLP-1 orders, from about $99/mo on a 3-month bundle
Read full review →From $169/mo
Get started →Enhance MD vs TMates: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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