Direct Meds vs TMates
In our scoring, TMates edges ahead overall (6.9 vs 6.4 out of 10), and TMates costs less for compounded semaglutide (about $576 a year less).
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Key differences
- Price
- TMates $249/mo vs Direct Meds $297/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $576 a year less with TMates)
- Coverage
- TMates 50 states (Direct Meds doesn't publish a state list)
- Included
- Direct Meds: medication, clinician visits, shipping; TMates: medication, clinician visits, shipping, coaching
- Safety
- FDA warning letters on record: Direct Meds 1, TMates none
Direct Meds
Affiliate partnerAlso prices oral compounded semaglutide and oral compounded tirzepatide
semaglutide
$297
Our score 6.4/10
TMates
Affiliate partnerBest for nationwide compounded GLP-1 availability including Puerto Rico
semaglutide
$249
Our score 6.9/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Direct Meds
TMates
Price
Semaglutide / month
$297/mo
Better on this row: $249/mo
Semaglutide / year (modeled)
$3,564
Better on this row: $2,988
Tirzepatide / month
$399/mo
Better on this row: $297/mo
Tirzepatide / year (modeled)
$4,788
Better on this row: $3,564
Oral semaglutide / month
$249/mo
Not listed
Oral tirzepatide / month
$299/mo
Not listed
Coverage
State availability
List not published
50 states
Oral option listed
Yes
Not listed
Included in the price
Medication, clinician visits, shipping
Medication, clinician visits, shipping, coaching
Terms & safety
Price shown
Before intake
Before intake
Cancel anytime
No
Better on this row: Yes
Minimum commitment
3-month prepay
None
Early-cancellation fee
Yes
Not disclosed
FDA warning letters
1 warning letter
Better on this row: None on record
Provider facts checked
August 2026
August 2026
Every dose and plan: Direct Meds · TMates
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Direct Meds if…
- Lists oral compounded semaglutide and oral compounded tirzepatide, which TMates doesn't price
- All-inclusive pricing covers medication, consultations, supplies, and 1–2 day temperature-controlled shipping
- LegitScript Certified
What to weigh up
- 1 FDA warning letter on record
- About $576 a year more than TMates for compounded semaglutide
Choose TMates if…
- About $576 a year less than Direct Meds for compounded semaglutide at standing prices
- Publishes its full state list (50 states)
- Cancel anytime
What to weigh up
- No third-party pharmacy accreditation (no LegitScript, PCAB, ACHC, or NABP)
- BBB rating of B+ (not accredited) with complaints centered on billing and cancellation
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Direct Meds
6.4/10
TMates
6.9/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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Direct Meds vs TMates: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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