Amazon One Medical vs One80Rx
In our scoring, Amazon One Medical edges ahead overall (8.5 vs 6.8 out of 10).
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Key differences
- Price
- Amazon One Medical $199/mo for brand-name Wegovy / Ozempic; One80Rx $129/mo for compounded semaglutide (different medications, so not compared on price)
- Coverage
- Amazon One Medical 50 states (One80Rx doesn't publish a state list)
- Included
- Amazon One Medical: clinician visits, shipping (not included: medication, labs); One80Rx: medication, clinician visits, shipping
Amazon One Medical
Best for brand-name GLP-1s with published per-dose cash prices and Amazon Pharmacy delivery
Brand-name Wegovy / Ozempic
$199
billed every 4 weeks
Our score 8.5/10
One80Rx
Best for low listed GLP-1 prices with flat dosing, including microdose and oral options
semaglutide
$129
“starting at” price
Our score 6.8/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Amazon One Medical
One80Rx
Price
Semaglutide / month
Not listed
$129/mo
“starting at” price
Tirzepatide / month
Not listed
$229/mo
“starting at” price
Brand Wegovy / Ozempic / month
$199/mo
billed every 4 weeks
Not listed
Brand Zepbound / Mounjaro / month
$299/mo
billed every 4 weeks
Not listed
Brand Wegovy pill / Rybelsus / month
$149/mo
Not listed
Brand Foundayo / month
$149/mo
Not listed
Coverage
State availability
50 states
List not published
Oral option listed
Yes
Not listed
Brand-name access listed
Wegovy / Ozempic, Zepbound / Mounjaro, Wegovy pill / Rybelsus, Foundayo
Not listed
Included in the price
Clinician visits, shipping
Not included: medication, labs
Medication, clinician visits, shipping
Terms & safety
Price shown
Before intake
Before intake
Lab work
Required
Not disclosed
Cancel anytime
Not disclosed
Yes
Minimum commitment
Not disclosed
None stated; recurring orders renew every 30 days until canceled
Refunds
Not disclosed
"Refunds will only be issued in the following situations: An incorrect prescription medication was sent. The product was damaged upon delivery. The product does not meet required safety standards. The order has not yet shipped. The prescribing Provider declines to issue a prescription."
Early-cancellation fee
Not disclosed
None
FDA warning letters
None on record
None on record
Provider facts checked
October 2026
September 2026
Every dose and plan: Amazon One Medical · One80Rx
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Amazon One Medical if…
- Lists brand-name Wegovy / Ozempic, brand-name Zepbound / Mounjaro and brand-name Wegovy pill / Rybelsus, which One80Rx doesn't price
- Publishes its full state list (50 states)
- Publishes cash prices for every GLP-1 dose up front, with manufacturer coupons applied automatically if eligible
What to weigh up
- Price doesn't include medication
- Online On-Demand Care is cash-only for medication; insurance needs scheduled visits near a One Medical office
Choose One80Rx if…
- Lists compounded semaglutide and compounded tirzepatide, which Amazon One Medical doesn't price
- Price includes medication; Amazon One Medical's doesn't
- Flat-rate pricing is promised with no consultation fee and no surcharge when your dose goes up
What to weigh up
- No published state list; confirm yours at signup
- Every price is a "from" figure confirmed only after provider review; the treatment pages show no price at all
Amazon One Medical and One80Rx in context
No medication appears on both price lists, so there is no fair price comparison to make. Amazon One Medical lists brand-name Wegovy / Ozempic, brand-name Zepbound / Mounjaro and brand-name Wegovy pill / Rybelsus, while One80Rx lists compounded semaglutide and compounded tirzepatide. If you have not settled on a medication yet, our Wegovy page and semaglutide page cover what each one is approved for and what it costs. In our scoring, Amazon One Medical is at 8.5 and One80Rx at 6.8 out of 10.
Amazon One Medical prices only brand-name medication, while One80Rx sells compounded versions prepared by a pharmacy. That is a bigger difference than the monthly figure suggests, and our compounded vs brand-name decision guide walks through it. One80Rx states that its price stays the same at every dose. Amazon One Medical does not say either way, which matters once you titrate up; the flat-price GLP-1 list shows who else commits to one price. Only Amazon One Medical lists a pill (brand-name Wegovy pill / Rybelsus). If avoiding injections is the point, read our Wegovy pill guide before choosing on price.
The next head-to-head for Amazon One Medical is Amazon One Medical vs OnlineSemaglutide.org; OnlineSemaglutide.org sells semaglutide and tirzepatide and lists 50 states. For One80Rx, it is One80Rx vs Vytora Health; Vytora Health sells semaglutide and tirzepatide and lists 50 states + DC. If neither fits, the wider shortlists are alternatives to Amazon One Medical and alternatives to One80Rx.
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Amazon One Medical
8.5/10
One80Rx
6.8/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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CoreAge Rx
Lowest-price compounded semaglutide and tirzepatide with one flat price at every dose
Read full review →From $79/mo (“starting at” price)
Get started →From $79/mo (sale price)
Get started →Gala
Compounded semaglutide or tirzepatide at one all-doses price on a yearly plan, with free shipping
Read full review →From $129/mo (starting dose)
Get started →Amazon One Medical vs One80Rx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Related comparisons
Continue exploring Amazon One Medical and One80Rx head-to-heads in the same category.
- Amazon One Medical vs Vytora Health
- Amazon One Medical vs CoreAge Rx
- Amazon One Medical vs Collective
- One80Rx vs Vytora Health
Or see the full category ranking, or alternatives to Amazon One Medical and One80Rx.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.