Amazon One Medical vs He & She MD
An in-depth comparison of two leading GLP-1 Providers
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Amazon One Medical
Best for: the most authoritative brand-name GLP-1 channel, with same-day delivery
Visit Amazon One Medical →
He & She MD
Best for: Cheapest per-month GLP-1 if you can prepay a full year
Visit He & She MD →Amazon One Medical and He & She MD are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, He & She MD starts lower at $99/mo versus $149/mo, and He & She MD is the option we'd start with for most patients. Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Amazon One Medical
He & She MD
Annual plan: billed $1,188 upfront. Advertised as a limited-time rate (banner: 'Injectable Semaglutide $199/month from just $99/month').
Billed $834 every 6 months, saving $360 vs monthly. Homepage GLP-1 Platinum starter rate: $139/mo for the first 6 months, then renews at $1,194 per 6 months, equivalent to $199/mo.
Billed $447 every 3 months, saving $270 vs monthly.
Billed monthly; the standing rate every term plan discounts from.
GLP-1 Platinum oral: $199/mo for the first 6 months, then renews at $1,434 per 6 months, equivalent to $239/mo. Oral is not on the /weight-loss/plans term ladder; figures from the homepage program cards and footnote 3.
Annual plan: billed $1,908 upfront.
Billed $1,194 every 6 months, saving $540 vs monthly. Homepage GLP-1 Platinum starter rate: $199/mo to start, then renews at $1,734 per 6 months, equivalent to $289/mo.
Billed $627 every 3 months, saving $270 vs monthly.
Billed monthly; the standing rate.
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What’s included
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
He & She MD
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Amazon One Medical
8.5/10
He & She MD
7.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Amazon One Medical | He & She MD |
|---|---|---|
| Starting Price | $149/mo | ✓$99/mo |
| Features | 6 features | ✓8 features |
| States Available | 50 | 50 |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →About He & She MD
He & She MD is a nationwide cash-pay telehealth clinic prescribing compounded semaglutide and tirzepatide, injectable or oral, plus brand-name access to Ozempic, Wegovy and Zepbound. Injectable semaglutide is $199/month billed monthly, falling to $139 on a six-month plan and $99 on the annual plan, prepaid for the year; tirzepatide runs $299/month down to $159 annually. Plans bundle medication, injection supplies, free shipping, unlimited provider messaging and GLP-1 coaching, and you are charged only if a clinician prescribes. Ships everywhere except Louisiana. LegitScript-certified.
Read our full He & She MD review →Pros & Cons
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
He & She MD
What we like
- Injectable semaglutide from $99/month on the annual plan, or $139/month on a six-month plan
- Compounded semaglutide and tirzepatide, injectable or oral, plus brand access to Ozempic, Wegovy, Zepbound
- Only charged if medication is prescribed, and no membership fees
- Every plan includes medication, injection supplies, free shipping and unlimited provider messaging
- GLP-1 coaching, nutrition guidance, and in-app progress tracking
- LegitScript-certified, and it names both compounding pharmacies it uses
- Ships to 49 states (all except Louisiana)
Watch-outs
- Compounded GLP-1s are not FDA-approved finished products (per the site FDA disclaimer)
- Does not ship to Louisiana or to PO boxes
- The $99 and $159 headline rates require a full year prepaid in a single charge
- Month-to-month costs $199 for semaglutide and $299 for tirzepatide, roughly double the annual rate
- Six-month starter rates step up on renewal: semaglutide $139 to $199, tirzepatide $199 to $289
- Cash-pay model, insurance billing not indicated
Our Verdict
He & She MD is our recommended choice here, particularly for Cheapest per-month GLP-1 if you can prepay a full year. Amazon One Medical is a solid alternative, especially if you want the most authoritative brand-name GLP-1 channel, with same-day delivery — compare the six-dimension breakdown and pricing below to weigh them for your situation.
Choose Amazon One Medical if…
You want the most authoritative brand-name GLP-1 channel, with same-day delivery and a starting price around $149/mo.
Choose He & She MD if…
You want Cheapest per-month GLP-1 if you can prepay a full year and a starting price around $99/mo.
Ready to start? Vetted GLP-1 providers
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ShedRx
Mainstream telehealth GLP-1 access
From $149/mo
Get started →bmiMD
Mainstream telehealth GLP-1 access
From $99/mo
Get started →Synergy Rx
Broadest drug catalog in the Lion MD white-label cluster
From $199/mo
Get started →Amazon One Medical vs He & She MD: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.