Yes Clinic vs Amazon One Medical
An in-depth comparison of two leading GLP-1 Providers
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Yes Clinic
Best for: flat per-dose pricing, and seeing every price without a quiz or an account
Visit Yes Clinic →
Amazon One Medical
Best for: the most authoritative brand-name GLP-1 channel, with same-day delivery
Visit Amazon One Medical →Yes Clinic and Amazon One Medical are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Yes Clinic starts lower at $129/mo versus $149/mo, and Amazon One Medical edges ahead overall (8.5 vs 7.8 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Yes Clinic
$387 for 3 months = $129/mo. 6 months is $699 = $116.50/mo and is labelled "price locked". No single-month plan renders. Flat at every dose.
$447 for 3 months and $894 for 6 months both work out at $149/mo, "price locked". No single-month plan renders. Flat at every dose.
Amazon One Medical
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What’s included
Yes Clinic
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Yes Clinic
7.8/10
Amazon One Medical
8.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Yes Clinic | Amazon One Medical |
|---|---|---|
| Starting Price | ✓$129/mo | $149/mo |
| Features | 6 features | 6 features |
| States Available | Not disclosed | 50 |
| Compounded | ✓ Yes | — |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About Yes Clinic
Yes Clinic sells compounded semaglutide and tirzepatide at one flat price that does not rise as your dose is titrated up — $129/mo for semaglutide and $149/mo for tirzepatide, with the consultation, shipping and membership all at $0. Every price is published on the product page without a quiz or an account. The trade-off is that the smallest plan is a three-month prepay charged upfront.
Read our full Yes Clinic review →About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →Pros & Cons
Yes Clinic
What we like
- Flat price at every dose — $129/mo semaglutide, $149/mo tirzepatide, and it does not climb as you titrate
- At $129/mo semaglutide sits only $20 below tirzepatide, so stepping up costs little
- "Every price is on this page. No quiz and no account needed to see it" — no email wall to see cost
- Consultation ($30), shipping and membership are all listed at $0: "the price on the tile is the whole price"
- Full refund if you cancel before the pharmacy dispenses; cancel yourself from your account
- Bilingual site with a working EN/ES toggle
Watch-outs
- Smallest plan is a 3-month prepay — $387 or $447 charged upfront, not a monthly bill
- Their live Terms of Use still contains an unfilled template placeholder: governed by the laws of the State of {GOVERNING_LAW_STATE}
- No pharmacy partner is named despite a "LegitScript Certified" banner in the footer
- No state list published: "Services are not available in all states"
- Product pages served different prices in source HTML than they render, so quote the figure you see on screen
- Support is email-only; no phone number published
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
Our Verdict
Amazon One Medical edges out Yes Clinic with a higher overall score of 8.5/10 and is particularly strong for the most authoritative brand-name GLP-1 channel, with same-day delivery. Yes Clinic remains a solid alternative, especially if you're looking for flat per-dose pricing, and seeing every price without a quiz or an account.
Choose Yes Clinic if…
You want flat per-dose pricing, and seeing every price without a quiz or an account and a starting price around $129/mo.
Choose Amazon One Medical if…
You want the most authoritative brand-name GLP-1 channel, with same-day delivery and a starting price around $149/mo.
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Get started →Yes Clinic vs Amazon One Medical: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.