RxSpan MD vs Willow
In our scoring, RxSpan MD edges ahead overall (8.1 vs 7.2 out of 10), and RxSpan MD costs less for compounded semaglutide (about $600 a year less).
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Key differences
- Price
- RxSpan MD $249/mo vs Willow $299/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $600 a year less with RxSpan MD)
- Coverage
- RxSpan MD 50 states; Willow 36 states (only RxSpan MD: Alabama, Alaska, Arkansas and 11 more)
- Included
- RxSpan MD: medication, clinician visits, shipping, coaching; Willow: medication, clinician visits, shipping
RxSpan MD
Affiliate partnerBest for physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
semaglutide
$249
Our score 8.1/10
Willow
Affiliate partnerBest for needle-free compounded semaglutide or tirzepatide tablets
semaglutide
$299
Our score 7.2/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
RxSpan MD
Willow
Price
Semaglutide / month
Better on this row: $249/mo
$299/mo
Semaglutide / year (modeled)
Better on this row: $2,988
$3,588
Tirzepatide / month
Better on this row: $329/mo
$399/mo
Tirzepatide / year (modeled)
Better on this row: $3,948
$4,788
Oral semaglutide / month
Better on this row: $249/mo
$299/mo
Oral semaglutide / year (modeled)
Better on this row: $2,988
$3,588
Oral tirzepatide / month
Better on this row: $349/mo
$399/mo
Oral tirzepatide / year (modeled)
Better on this row: $4,188
$4,788
Brand Wegovy / Ozempic / month
$1,299/mo
Not listed
Brand Zepbound / Mounjaro / month
$1,069/mo
Not listed
Coverage
State availability
50 states
36 states
Oral option listed
Yes
Yes
Brand-name access listed
Wegovy / Ozempic, Zepbound / Mounjaro
Not listed
Included in the price
Medication, clinician visits, shipping, coaching
Medication, clinician visits, shipping
FSA/HSA accepted
Not listed
Yes
Terms & safety
Price shown
Before intake
Before intake
Cancel anytime
Yes
Yes
Minimum commitment
None
Monthly auto-renewing plan; no minimum term stated. 'Your program renews automatically so you never miss a dose.'
Refunds
Not disclosed
'If you cancel before your prescription is sent to the pharmacy, you'll receive a full refund within 5-10 business days.' Terms: 'charges are non-refundable once incurred' and prescription products 'are not returnable'.
Early-cancellation fee
None
Not disclosed
FDA warning letters
None on record
None on record
Provider facts checked
August 2026
October 2026
Show where they differ by stateHide state lists
Only RxSpan MD (14 states)
- Alabama
- Alaska
- Arkansas
- Delaware
- Kansas
- Louisiana
- Mississippi
- New Mexico
- North Dakota
- Rhode Island
- South Dakota
- Utah
- Vermont
- West Virginia
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose RxSpan MD if…
- About $600 a year less than Willow for compounded semaglutide at standing prices
- Lists brand-name Wegovy / Ozempic and brand-name Zepbound / Mounjaro, which Willow doesn't price
- Serves 14 states that Willow doesn't
What to weigh up
- Compounded pricing ($249 semaglutide / $329 tirzepatide) sits mid-to-high versus the cheapest telehealth options
- Brand-name GLP-1 is priced steeply (Wegovy $1,349, Ozempic $1,299, Zepbound $1,069)
Choose Willow if…
- Accepts FSA/HSA cards
- All-in plan price covers the medication, doctor evaluation, unlimited doctor messaging and shipping
- Names its partner compounding pharmacies in its Terms
What to weigh up
- About $600 a year more than RxSpan MD for compounded semaglutide
- Not available in 14 states that RxSpan MD serves
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
RxSpan MD
8.1/10
Willow
7.2/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Ready to start? Vetted GLP-1 providers
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Ivim Health
Compounded GLP-1 with weekly provider check-ins and health coaches, under a required monthly membership
Read full review →From $65/mo + membership
Get started →From $247/mo
Get started →From $139/mo
Get started →RxSpan MD vs Willow: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.