Prime Doctor RX vs NewSelf
An in-depth comparison of two leading GLP-1 Providers
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Prime Doctor RX
Best for: month-to-month compounded GLP-1s with every prepaid tier priced up front, plus TRT
Visit Prime Doctor RX →
NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →Prime Doctor RX and NewSelf are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $249/mo, and NewSelf edges ahead overall (8.3 vs 7.0 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Prime Doctor RX
'Month-to-month: $249 every 4 weeks'. Prepaid: '12 weeks upfront $657 · $219/mo', '24 weeks upfront $1,194 · $199/mo', '52 weeks upfront $2,327 · $179/mo' (each /mo figure is per 4 weeks).
'Month-to-month: $339 every 4 weeks'. Prepaid: '12 weeks upfront $927 · $309/mo', '24 weeks upfront $1,734 · $289/mo', '52 weeks upfront $3,497 · $269/mo' (each /mo figure is per 4 weeks).
'Month-to-month: $279 every 4 weeks'. Prepaid: '12 weeks upfront $777 · $259/mo', '24 weeks upfront $1,434 · $239/mo', '52 weeks upfront $2,717 · $209/mo' (each /mo figure is per 4 weeks).
NewSelf
All dosages same price
All dosages same price
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What’s included
Prime Doctor RX
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Not disclosed
Lab work
Not disclosed
Coaching
Not disclosed
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Prime Doctor RX
7.0/10
NewSelf
8.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Prime Doctor RX | NewSelf |
|---|---|---|
| Starting Price | $249/mo | ✓$100/mo |
| Features | ✓7 features | 6 features |
| States Available | Not disclosed | 49 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | ✓None | 1 warning |
About Prime Doctor RX
Prime Doctor RX is a telehealth brand selling compounded semaglutide injections, tirzepatide injections and an oral semaglutide tablet, with care provided by the medical group OpenLoop Healthcare Partners, PC. Month-to-month plans cost $249, $339 and $279, charged every 4 weeks, and every longer prepaid option is priced on the homepage before you start. It also runs testosterone and enclomiphene programs for men.
Read our full Prime Doctor RX review →About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →Pros & Cons
Prime Doctor RX
What we like
- Every plan is priced on the homepage before you start, with month-to-month and 12-, 24- and 52-week prepaid rates for each drug
- Names its prescribing medical group, OpenLoop Healthcare Partners, PC
- Offers compounded semaglutide and tirzepatide injections plus a daily oral semaglutide tablet
- States the real billing cycle plainly: month-to-month plans are charged every 4 weeks
- Month-to-month plans can be canceled at any time, and refunds can be requested for unused future periods
- Also runs testosterone and enclomiphene programs for eligible men, with the hormone-care state list published
Watch-outs
- The '$179/mo' headline is the 52-week prepay average, paid as one $2,327 charge; month-to-month semaglutide is $249
- Plans are charged every 4 weeks, so month-to-month billing comes to 13 charges a year, not 12
- Ending a prepaid plan early can reprice the months you used at the higher month-to-month rate
- No dispensing pharmacy is named anywhere on the site
- No LegitScript certification, and no Trustpilot profile or other third-party reviews could be found
- Weight-loss availability by state is not published; it is confirmed during intake
- No phone number is published on the site; support is by email and an on-site chat widget
- Product cards never say compounded or brand-name; only a footnote says compounded medications are not FDA-approved
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Our Verdict
NewSelf edges out Prime Doctor RX with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. Prime Doctor RX remains a solid alternative, especially if you're looking for month-to-month compounded GLP-1s with every prepaid tier priced up front, plus TRT.
Choose Prime Doctor RX if…
You want month-to-month compounded GLP-1s with every prepaid tier priced up front, plus TRT and a starting price around $249/mo.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
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Synergy Rx
Broadest drug catalog in the Lion MD white-label cluster
From $199/mo
Get started →RxSpan MD
Physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
From $179/mo
Get started →Strut Health
Oral-lozenge compounded GLP-1 access
From $99/mo
Get started →Prime Doctor RX vs NewSelf: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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