OnlyRx vs Amazon One Medical
An in-depth comparison of two leading GLP-1 Providers
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OnlyRx
Best for: compounded GLP-1 in oral-tablet and injection with named prescribers
Visit OnlyRx →
Amazon One Medical
Best for: the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings
Visit Amazon One Medical →OnlyRx and Amazon One Medical are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Amazon One Medical starts lower at $149/mo versus $179/mo, and Amazon One Medical edges ahead overall (8.5 vs 6.4 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
OnlyRx
Amazon One Medical
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What’s included
OnlyRx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
OnlyRx
6.4/10
Amazon One Medical
8.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | OnlyRx | Amazon One Medical |
|---|---|---|
| Starting Price | $179/mo | ✓$149/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | 50 |
| Compounded | — | — |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About OnlyRx
OnlyRx is a cash-pay GLP-1 telehealth platform offering compounded semaglutide and tirzepatide in both injection and oral disintegrating tablet (ODT) forms — an uncommon needle-free option. It names its prescribers and a four-pharmacy fulfillment network, and offers brand-name GLP-1s when prescribed. Available in all 50 states with Buy Now Pay Later; compounded semaglutide injection starts at $179/mo on a summer promo.
Read our full OnlyRx review →About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →Pros & Cons
OnlyRx
What we like
- Four-pharmacy network: Belmar, Strive, Epiq Scripts, and Casa Pharma RX
- Named prescribers on the public site: Dr. Carr (MD), Dr. Tenbrink (MD), Dr. Italia (MD), Dr. Mansour (DO)
- Oral disintegrating tablet (ODT) form for both semaglutide and tirzepatide — good for needle-averse patients
- Pricing, drug list, pharmacy partners, and physician roster all visible on the public site
- LegitScript Certified
- Brand-name Ozempic, Wegovy, Zepbound, and Mounjaro available alongside the compounded line
Watch-outs
- Promo pricing ($179 semaglutide injection) is prominent, but post-promo maintenance pricing isn't shown
- No titration-ladder pricing — you can't see costs at 1.0 mg or 2.4 mg maintenance
- Refund / cancellation policy not stated on the homepage
- Lab-work requirement not stated
- Operating corporate entity not disclosed
- Epiq Scripts is the one named pharmacy partner not yet independently verified
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
Our Verdict
Amazon One Medical edges out OnlyRx with a higher overall score of 8.5/10 and is particularly strong for the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings. OnlyRx remains a solid alternative, especially if you're looking for compounded GLP-1 in oral-tablet and injection with named prescribers.
Choose OnlyRx if…
You want compounded GLP-1 in oral-tablet and injection with named prescribers and a starting price around $179/mo.
Choose Amazon One Medical if…
You want the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings and a starting price around $149/mo.
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Get started →OnlyRx vs Amazon One Medical: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.