Jyra Health vs NewSelf
An in-depth comparison of two leading GLP-1 Providers
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Jyra Health
Best for: very low-cost compounded semaglutide or tirzepatide in any state
Visit Jyra Health →
NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →Jyra Health and NewSelf are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Jyra Health starts lower at $99/mo versus $100/mo, and NewSelf edges ahead overall (8.3 vs 7.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Jyra Health
'Best Value GLP-1'; no membership/hidden fees, no insurance, free express delivery
$133/mo flagged 'Limited Time' — verify current price
NewSelf
All dosages same price
All dosages same price
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What’s included
Jyra Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Jyra Health
7.7/10
NewSelf
8.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Jyra Health | NewSelf |
|---|---|---|
| Starting Price | ✓$99/mo | $100/mo |
| Features | ✓8 features | 6 features |
| States Available | ✓50 | 49 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | ✓None | 1 warning |
About Jyra Health
Jyra Health is an online weight-loss and longevity telehealth clinic offering compounded GLP-1 — semaglutide from $99/mo and tirzepatide from $133/mo (limited time) — prescribed by board-certified providers in all 50 states, with no insurance, no monthly membership, no hidden fees, and free express delivery. It publishes a full legal suite (Privacy, Terms, HIPAA, Refunds). Compounded medications are not FDA-approved (disclosed); pricing is promotional, the compounding pharmacy is not named, and its LegitScript badge is self-hosted and not independently verified.
Read our full Jyra Health review →About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →Pros & Cons
Jyra Health
What we like
- Among the lowest compounded pricing — semaglutide from $99/mo and tirzepatide from $133/mo, with no membership and no hidden fees
- Board-certified providers in all 50 states; no insurance required and free express delivery
- Offers both compounded semaglutide and tirzepatide, plus a longevity track
- Full legal suite published (Privacy, Terms, HIPAA, Refunds & Cancellations)
Watch-outs
- The $133/mo tirzepatide price is flagged 'limited time' — verify current pricing before enrolling
- Compounded medications are not FDA-approved (the site discloses this) — not brand Wegovy, Zepbound, Ozempic, or Mounjaro
- Displays a self-hosted LegitScript badge but no verifiable seal or listing
- Compounding pharmacy not named; appears to be a newer, smaller clinic (~300 patients/month)
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Our Verdict
NewSelf edges out Jyra Health with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. Jyra Health remains a solid alternative, especially if you're looking for very low-cost compounded semaglutide or tirzepatide in any state.
Choose Jyra Health if…
You want very low-cost compounded semaglutide or tirzepatide in any state and a starting price around $99/mo.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
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From $99/mo
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Compounded GLP-1 alongside NAD+, peptide and longevity add-ons
From $197/mo
Get started →Jyra Health vs NewSelf: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.