Jyra Health vs Amazon One Medical
An in-depth comparison of two leading GLP-1 Providers
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Jyra Health
Best for: very low-cost compounded semaglutide or tirzepatide in any state
Visit Jyra Health →
Amazon One Medical
Best for: the most authoritative brand-name GLP-1 channel, with same-day delivery
Visit Amazon One Medical →Jyra Health and Amazon One Medical are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Jyra Health starts lower at $99/mo versus $149/mo, and Amazon One Medical edges ahead overall (8.5 vs 7.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Jyra Health
'Best Value GLP-1'; no membership/hidden fees, no insurance, free express delivery
$133/mo flagged 'Limited Time' — verify current price
Amazon One Medical
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What’s included
Jyra Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Jyra Health
7.7/10
Amazon One Medical
8.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Jyra Health | Amazon One Medical |
|---|---|---|
| Starting Price | ✓$99/mo | $149/mo |
| Features | ✓8 features | 6 features |
| States Available | 50 | 50 |
| Compounded | ✓ Yes | — |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About Jyra Health
Jyra Health is an online weight-loss and longevity telehealth clinic offering compounded GLP-1 — semaglutide from $99/mo and tirzepatide from $133/mo (limited time) — prescribed by board-certified providers in all 50 states, with no insurance, no monthly membership, no hidden fees, and free express delivery. It publishes a full legal suite (Privacy, Terms, HIPAA, Refunds). Compounded medications are not FDA-approved (disclosed); pricing is promotional, the compounding pharmacy is not named, and its LegitScript badge is self-hosted, so it doesn't prove certification on its own.
Read our full Jyra Health review →About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →Pros & Cons
Jyra Health
What we like
- Among the lowest compounded pricing — semaglutide from $99/mo and tirzepatide from $133/mo, with no membership and no hidden fees
- Board-certified providers in all 50 states; no insurance required and free express delivery
- Offers both compounded semaglutide and tirzepatide, plus a longevity track
- Full legal suite published (Privacy, Terms, HIPAA, Refunds & Cancellations)
Watch-outs
- The $133/mo tirzepatide price is flagged 'limited time' — check current pricing before enrolling
- Compounded medications are not FDA-approved (the site discloses this) — not brand Wegovy, Zepbound, Ozempic, or Mounjaro
- Displays a self-hosted LegitScript badge but no verifiable seal or listing
- Compounding pharmacy not named; appears to be a newer, smaller clinic (~300 patients/month)
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
Our Verdict
Amazon One Medical edges out Jyra Health with a higher overall score of 8.5/10 and is particularly strong for the most authoritative brand-name GLP-1 channel, with same-day delivery. Jyra Health remains a solid alternative, especially if you're looking for very low-cost compounded semaglutide or tirzepatide in any state.
Choose Jyra Health if…
You want very low-cost compounded semaglutide or tirzepatide in any state and a starting price around $99/mo.
Choose Amazon One Medical if…
You want the most authoritative brand-name GLP-1 channel, with same-day delivery and a starting price around $149/mo.
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TrimRx
Best overall value
From $149/mo
Get started →Sprout Health
LegitScript-certified compounded GLP-1 via named pharmacies
From $149/mo
Get started →Care Bare Rx
LGBTQ+-inclusive compounded GLP-1 telehealth
From $199/mo
Get started →Jyra Health vs Amazon One Medical: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.