Enhance MD vs PlexusDx
In our scoring, Enhance MD edges ahead overall (8.2 vs 7.0 out of 10).
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Key differences
- Price
- Enhance MD $212/mo on a 12-month prepaid plan; PlexusDx $129/mo no prepay listed (compounded semaglutide · not like-for-like, so neither is marked cheaper)
- Coverage
- Enhance MD 39 states; PlexusDx 50 states (only PlexusDx: Alabama, Arkansas, Georgia and 8 more)
- Included
- Enhance MD: medication, clinician visits, labs; PlexusDx: medication, clinician visits
Enhance MD
Affiliate partnerBest for lab-monitored compounded GLP-1 with mandatory video visit
semaglutide
$212
on a 12-month prepaid plan · $112 first month
Our score 8.2/10
PlexusDx
Affiliate partnerBest for nationwide compounded GLP-1 with optional genetic-test personalization
semaglutide
$129
microdose plan
Our score 7.0/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Enhance MD
PlexusDx
Price
Semaglutide / month
$212/mo
on a 12-month prepaid plan · $112 first month
$129/mo
microdose plan
Semaglutide / year (modeled)
$2,544
$1,548
Tirzepatide / month
$169/mo
on a 12-month prepaid plan
$249/mo
starting dose
Tirzepatide / year (modeled)
$2,028
$2,988
Coverage
State availability
39 states
50 states
Included in the price
Medication, clinician visits, labs
Medication, clinician visits
Terms & safety
Price shown
Before intake
Before intake
Lab work
Required
Not disclosed
Video visit
Required
Not disclosed
Cancel anytime
Yes
Not disclosed
Minimum commitment
12-month plan for the listed price
Not disclosed
FDA warning letters
None on record
None on record
Provider facts checked
August 2026
August 2026
Show where they differ by stateHide state lists
Only PlexusDx (11 states)
- Alabama
- Arkansas
- Georgia
- Hawaii
- Louisiana
- Mississippi
- Missouri
- North Dakota
- South Carolina
- Tennessee
- West Virginia
Every dose and plan: Enhance MD · PlexusDx
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Enhance MD if…
- Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
- Mandatory video visit with a US-licensed MD or NP before your first prescription — not a pure questionnaire model
- Uses LegitScript-certified 503A pharmacies (Tru Meds Rx, Strive Pharmacy, Pharmacy Hub)
What to weigh up
- Its $212/mo compounded semaglutide price needs a 12-month prepaid plan
- Not available in 11 states that PlexusDx serves
Choose PlexusDx if…
- Its $129/mo compounded semaglutide price needs no prepay; Enhance MD's $212 needs a 12-month prepay
- Serves 11 states that Enhance MD doesn't
- Optional Precision Peptide genetic panel adds a personalization angle
What to weigh up
- Compounded medications only; no FDA-approved brand options
- Specific compounding pharmacies not named
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Enhance MD
8.2/10
PlexusDx
7.0/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online.
No insurance needed · vetted by our editors
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ShedRx
Compounded GLP-1 as an injection, drops or lozenges, with lower rates on 6- and 12-month plans
Read full review →From $299/mo (after intro offer)
Get started →bmiMD
One flat compounded GLP-1 price at every dose: semaglutide $159/mo month to month, $119/mo on a 12-month plan
Read full review →From $159/mo
Get started →altRX
Low-cost compounded GLP-1s with brand-name Zepbound, Wegovy and Ozempic as options
Read full review →From $89/mo
Get started →Enhance MD vs PlexusDx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.